Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: EYA3

Gene summary for EYA3

Gene summary.

Gene information	Species	Human
	Gene symbol	EYA3
	Gene ID	2140
	Gene name	EYA transcriptional coactivator and phosphatase 3
	Gene Alias	EYA3
	Cytomap	1p35.3
	Gene Type	protein-coding
	GO ID	GO:0003008
	UniProtAcc	Q99504

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
2140	EYA3	A001-C-014	Human	Colorectum	FAP	2.28e-13	-4.04e-01	0.0135
2140	EYA3	A002-C-016	Human	Colorectum	FAP	8.40e-20	-3.87e-01	0.0521
2140	EYA3	A015-C-002	Human	Colorectum	FAP	6.50e-12	-4.97e-01	-0.0763
2140	EYA3	A001-C-007	Human	Colorectum	CRC	4.26e-03	-4.00e-01	0.1899
2140	EYA3	A001-C-203	Human	Colorectum	FAP	1.77e-06	-2.25e-01	-0.0481
2140	EYA3	A002-C-116	Human	Colorectum	FAP	5.15e-24	-4.32e-01	-0.0452
2140	EYA3	A014-C-008	Human	Colorectum	FAP	1.39e-13	-4.31e-01	-0.191
2140	EYA3	A018-E-020	Human	Colorectum	FAP	8.33e-22	-4.90e-01	-0.2034
2140	EYA3	F034	Human	Colorectum	FAP	2.17e-15	-3.41e-01	-0.0665
2140	EYA3	F072B	Human	Colorectum	FAP	6.35e-10	-3.39e-01	0.257
2140	EYA3	CRC-1-8810	Human	Colorectum	CRC	5.62e-08	-3.78e-01	0.6257
2140	EYA3	CRC-3-11773	Human	Colorectum	CRC	2.51e-11	-4.00e-01	0.2564
2140	EYA3	LZE4T	Human	Esophagus	ESCC	1.07e-08	1.76e-01	0.0811
2140	EYA3	LZE7T	Human	Esophagus	ESCC	2.82e-04	1.50e-01	0.0667
2140	EYA3	LZE8T	Human	Esophagus	ESCC	3.60e-05	1.18e-01	0.067
2140	EYA3	LZE20T	Human	Esophagus	ESCC	8.74e-03	8.14e-02	0.0662
2140	EYA3	LZE24T	Human	Esophagus	ESCC	2.31e-16	1.99e-01	0.0596
2140	EYA3	LZE6T	Human	Esophagus	ESCC	1.05e-04	1.78e-01	0.0845
2140	EYA3	P1T-E	Human	Esophagus	ESCC	1.02e-03	1.77e-01	0.0875
2140	EYA3	P2T-E	Human	Esophagus	ESCC	6.08e-11	2.37e-01	0.1177

Page: 1 2 3 4 5 6

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:200123310	Cervix	CC	regulation of apoptotic signaling pathway	96/2311	356/18723	4.08e-14	3.05e-11	96
GO:200123410	Cervix	CC	negative regulation of apoptotic signaling pathway	56/2311	224/18723	1.39e-07	6.70e-06	56
GO:009719110	Cervix	CC	extrinsic apoptotic signaling pathway	52/2311	219/18723	2.06e-06	6.34e-05	52
GO:00064708	Cervix	CC	protein dephosphorylation	60/2311	281/18723	1.33e-05	2.68e-04	60
GO:200123610	Cervix	CC	regulation of extrinsic apoptotic signaling pathway	37/2311	151/18723	2.80e-05	4.65e-04	37
GO:00093149	Cervix	CC	response to radiation	86/2311	456/18723	3.50e-05	5.63e-04	86
GO:00165705	Cervix	CC	histone modification	84/2311	463/18723	1.70e-04	2.01e-03	84
GO:20010209	Cervix	CC	regulation of response to DNA damage stimulus	46/2311	219/18723	1.92e-04	2.23e-03	46
GO:00102126	Cervix	CC	response to ionizing radiation	34/2311	148/18723	2.23e-04	2.53e-03	34
GO:00510528	Cervix	CC	regulation of DNA metabolic process	65/2311	359/18723	9.25e-04	7.84e-03	65
GO:00163117	Cervix	CC	dephosphorylation	73/2311	417/18723	1.23e-03	9.87e-03	73
GO:200123710	Cervix	CC	negative regulation of extrinsic apoptotic signaling pathway	23/2311	97/18723	1.39e-03	1.10e-02	23
GO:20012332	Colorectum	MSS	regulation of apoptotic signaling pathway	116/3467	356/18723	1.02e-10	1.06e-08	116
GO:00510522	Colorectum	MSS	regulation of DNA metabolic process	108/3467	359/18723	5.86e-08	3.10e-06	108
GO:00510542	Colorectum	MSS	positive regulation of DNA metabolic process	69/3467	201/18723	6.33e-08	3.26e-06	69
GO:20012342	Colorectum	MSS	negative regulation of apoptotic signaling pathway	72/3467	224/18723	6.17e-07	2.29e-05	72
GO:20010202	Colorectum	MSS	regulation of response to DNA damage stimulus	64/3467	219/18723	7.20e-05	1.21e-03	64
GO:00971912	Colorectum	MSS	extrinsic apoptotic signaling pathway	63/3467	219/18723	1.34e-04	2.03e-03	63
GO:0016570	Colorectum	MSS	histone modification	113/3467	463/18723	8.37e-04	8.68e-03	113
GO:20010221	Colorectum	MSS	positive regulation of response to DNA damage stimulus	33/3467	105/18723	9.83e-04	9.86e-03	33

Page: 1 2 3 4 5 6 7 8 9

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

EYA3

SNV

Missense_Mutation

novel

c.1676N>A

p.Gly559Glu

p.G559E

Q99504

protein_coding

deleterious(0.02)

possibly_damaging(0.463)

TCGA-AN-A04C-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

EYA3

SNV

Missense_Mutation

c.607N>G

p.Leu203Val

p.L203V

Q99504

protein_coding

tolerated(0.05)

benign(0.355)

TCGA-B6-A0IJ-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unknown

EYA3

SNV

Missense_Mutation

c.1551N>G

p.Ser517Arg

p.S517R

Q99504

protein_coding

deleterious(0)

probably_damaging(0.998)

TCGA-E9-A22H-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

EYA3

insertion

Frame_Shift_Ins

novel

c.1324_1325insTGCAGTACACTAATGCTATGAAGCCC

p.Lys442MetfsTer16

p.K442Mfs*16

Q99504

protein_coding

TCGA-A8-A07J-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

5-fluorouracil

EYA3

insertion

Nonsense_Mutation

novel

c.1468_1469insGAGACTCCGTCTCTAAATAAATAAATAAAAGGTATTGACAAGGA

p.Leu490ArgfsTer7

p.L490Rfs*7

Q99504

protein_coding

TCGA-AN-A0FW-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Unknown

EYA3

insertion

Frame_Shift_Ins

novel

c.634_635insCTTTCTATGTCCAGGATCCCTTTAAGATTCTGAGGAAAGCATGG

p.Tyr212SerfsTer36

p.Y212Sfs*36

Q99504

protein_coding

TCGA-BH-A0HX-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adrimycin

EYA3

SNV

Missense_Mutation

c.292A>C

p.Thr98Pro

p.T98P

Q99504

protein_coding

tolerated(0.14)

benign(0.006)

TCGA-FU-A3HZ-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Chemotherapy

cisplatin

EYA3

SNV

Missense_Mutation

novel

c.1253N>A

p.Arg418His

p.R418H

Q99504

protein_coding

deleterious(0)

probably_damaging(1)

TCGA-ZJ-AAXN-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

EYA3

SNV

Missense_Mutation

c.1505T>C

p.Phe502Ser

p.F502S

Q99504

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-A6-5665-01

Colorectum

colon adenocarcinoma

Female

>=65

I/II

Unknown

EYA3

SNV

Missense_Mutation

c.781N>C

p.Thr261Pro

p.T261P

Q99504

protein_coding

tolerated(0.1)

benign(0)

TCGA-G4-6586-01

Colorectum

colon adenocarcinoma

Female

>=65

I/II

Unknown

Page: 1 2 3 4 5

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1