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Gene: EVA1C |
Gene summary for EVA1C |
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Gene information | Species | Human | Gene symbol | EVA1C | Gene ID | 59271 |
Gene name | eva-1 homolog C | |
Gene Alias | B18 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P58658 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59271 | EVA1C | A002-C-016 | Human | Colorectum | FAP | 6.78e-21 | -5.04e-01 | 0.0521 |
59271 | EVA1C | A015-C-002 | Human | Colorectum | FAP | 1.09e-09 | -3.54e-01 | -0.0763 |
59271 | EVA1C | A001-C-007 | Human | Colorectum | CRC | 3.47e-06 | -4.89e-01 | 0.1899 |
59271 | EVA1C | A001-C-203 | Human | Colorectum | FAP | 1.65e-14 | -3.83e-01 | -0.0481 |
59271 | EVA1C | A002-C-116 | Human | Colorectum | FAP | 9.93e-24 | -4.90e-01 | -0.0452 |
59271 | EVA1C | A014-C-008 | Human | Colorectum | FAP | 5.76e-15 | -5.01e-01 | -0.191 |
59271 | EVA1C | A018-E-020 | Human | Colorectum | FAP | 1.12e-23 | -5.59e-01 | -0.2034 |
59271 | EVA1C | F034 | Human | Colorectum | FAP | 4.33e-26 | -5.14e-01 | -0.0665 |
59271 | EVA1C | F072B | Human | Colorectum | FAP | 4.16e-23 | -4.98e-01 | 0.257 |
59271 | EVA1C | CRC-1-8810 | Human | Colorectum | CRC | 2.73e-06 | -2.41e-01 | 0.6257 |
59271 | EVA1C | CRC-3-11773 | Human | Colorectum | CRC | 3.09e-14 | -3.62e-01 | 0.2564 |
59271 | EVA1C | LZE5T | Human | Esophagus | ESCC | 2.37e-05 | 5.89e-02 | 0.0514 |
59271 | EVA1C | LZE20T | Human | Esophagus | ESCC | 1.27e-04 | 4.26e-02 | 0.0662 |
59271 | EVA1C | LZE24T | Human | Esophagus | ESCC | 4.62e-03 | -1.72e-01 | 0.0596 |
59271 | EVA1C | LZE21T | Human | Esophagus | ESCC | 6.65e-04 | 2.77e-02 | 0.0655 |
59271 | EVA1C | P1T-E | Human | Esophagus | ESCC | 1.38e-04 | 5.14e-01 | 0.0875 |
59271 | EVA1C | P2T-E | Human | Esophagus | ESCC | 1.74e-02 | 3.91e-02 | 0.1177 |
59271 | EVA1C | P4T-E | Human | Esophagus | ESCC | 8.34e-09 | 2.10e-01 | 0.1323 |
59271 | EVA1C | P5T-E | Human | Esophagus | ESCC | 8.37e-03 | -1.26e-01 | 0.1327 |
59271 | EVA1C | P8T-E | Human | Esophagus | ESCC | 1.69e-05 | 1.48e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EVA1C | SNV | Missense_Mutation | novel | c.545N>T | p.Lys182Met | p.K182M | P58658 | protein_coding | tolerated(0.06) | probably_damaging(0.941) | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
EVA1C | SNV | Missense_Mutation | c.843N>C | p.Gln281His | p.Q281H | P58658 | protein_coding | deleterious(0.01) | benign(0.332) | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EVA1C | SNV | Missense_Mutation | c.1220N>T | p.Ala407Val | p.A407V | P58658 | protein_coding | tolerated(0.08) | probably_damaging(0.997) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EVA1C | SNV | Missense_Mutation | c.958G>A | p.Glu320Lys | p.E320K | P58658 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-LL-A6FP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
EVA1C | insertion | Frame_Shift_Ins | novel | c.1264_1265insTGCTAATTACAGTATTAAAAAGTAATTCGTTAGACAT | p.Glu422ValfsTer? | p.E422Vfs*? | P58658 | protein_coding | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | ||
EVA1C | SNV | Missense_Mutation | c.1106A>G | p.Glu369Gly | p.E369G | P58658 | protein_coding | tolerated(0.11) | possibly_damaging(0.559) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EVA1C | SNV | Missense_Mutation | novel | c.575N>A | p.Gly192Asp | p.G192D | P58658 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
EVA1C | SNV | Missense_Mutation | rs779127738 | c.1172N>T | p.Ser391Leu | p.S391L | P58658 | protein_coding | tolerated(0.06) | benign(0.038) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
EVA1C | SNV | Missense_Mutation | c.452N>G | p.Tyr151Cys | p.Y151C | P58658 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-DM-A285-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
EVA1C | SNV | Missense_Mutation | novel | c.581N>T | p.Arg194Met | p.R194M | P58658 | protein_coding | tolerated(0.13) | possibly_damaging(0.663) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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