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Gene: ERI3 |
Gene summary for ERI3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ERI3 | Gene ID | 79033 |
| Gene name | ERI1 exoribonuclease family member 3 | |
| Gene Alias | PINT1 | |
| Cytomap | 1p34.1 | |
| Gene Type | protein-coding | GO ID | GO:0000459 | UniProtAcc | B4DN03 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79033 | ERI3 | P20T-E | Human | Esophagus | ESCC | 4.37e-31 | 8.01e-01 | 0.1124 |
| 79033 | ERI3 | P21T-E | Human | Esophagus | ESCC | 1.51e-73 | 1.56e+00 | 0.1617 |
| 79033 | ERI3 | P22T-E | Human | Esophagus | ESCC | 4.29e-48 | 8.08e-01 | 0.1236 |
| 79033 | ERI3 | P23T-E | Human | Esophagus | ESCC | 2.88e-44 | 1.12e+00 | 0.108 |
| 79033 | ERI3 | P24T-E | Human | Esophagus | ESCC | 9.67e-40 | 7.76e-01 | 0.1287 |
| 79033 | ERI3 | P26T-E | Human | Esophagus | ESCC | 1.19e-48 | 9.64e-01 | 0.1276 |
| 79033 | ERI3 | P27T-E | Human | Esophagus | ESCC | 3.45e-51 | 9.84e-01 | 0.1055 |
| 79033 | ERI3 | P28T-E | Human | Esophagus | ESCC | 6.84e-30 | 7.00e-01 | 0.1149 |
| 79033 | ERI3 | P30T-E | Human | Esophagus | ESCC | 2.46e-30 | 1.09e+00 | 0.137 |
| 79033 | ERI3 | P31T-E | Human | Esophagus | ESCC | 1.47e-59 | 1.08e+00 | 0.1251 |
| 79033 | ERI3 | P32T-E | Human | Esophagus | ESCC | 6.88e-60 | 1.24e+00 | 0.1666 |
| 79033 | ERI3 | P36T-E | Human | Esophagus | ESCC | 2.49e-17 | 7.09e-01 | 0.1187 |
| 79033 | ERI3 | P37T-E | Human | Esophagus | ESCC | 1.62e-44 | 1.10e+00 | 0.1371 |
| 79033 | ERI3 | P38T-E | Human | Esophagus | ESCC | 5.17e-11 | 6.57e-01 | 0.127 |
| 79033 | ERI3 | P39T-E | Human | Esophagus | ESCC | 7.77e-34 | 7.11e-01 | 0.0894 |
| 79033 | ERI3 | P40T-E | Human | Esophagus | ESCC | 5.12e-17 | 5.87e-01 | 0.109 |
| 79033 | ERI3 | P42T-E | Human | Esophagus | ESCC | 1.07e-26 | 7.47e-01 | 0.1175 |
| 79033 | ERI3 | P44T-E | Human | Esophagus | ESCC | 1.66e-19 | 7.20e-01 | 0.1096 |
| 79033 | ERI3 | P47T-E | Human | Esophagus | ESCC | 1.61e-17 | 3.07e-01 | 0.1067 |
| 79033 | ERI3 | P48T-E | Human | Esophagus | ESCC | 7.74e-30 | 5.84e-01 | 0.0959 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
| GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
| GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
| GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
| GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
| GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
| GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
| GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
| GO:00905033 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, exonucleolytic | 35/8552 | 42/18723 | 5.35e-07 | 7.11e-06 | 35 |
| GO:00004603 | Esophagus | ESCC | maturation of 5.8S rRNA | 30/8552 | 35/18723 | 1.07e-06 | 1.34e-05 | 30 |
| GO:00004693 | Esophagus | ESCC | cleavage involved in rRNA processing | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
| GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
| GO:00004663 | Esophagus | ESCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 21/8552 | 24/18723 | 2.57e-05 | 2.17e-04 | 21 |
| GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
| GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
| GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
| GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
| GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
| GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
| GO:0090501 | Liver | Cirrhotic | RNA phosphodiester bond hydrolysis | 54/4634 | 152/18723 | 1.89e-03 | 1.19e-02 | 54 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ERI3 | SNV | Missense_Mutation | rs776082167 | c.563N>C | p.Val188Ala | p.V188A | O43414 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
| ERI3 | SNV | Missense_Mutation | c.775C>A | p.Gln259Lys | p.Q259K | O43414 | protein_coding | tolerated(0.45) | benign(0.005) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
| ERI3 | SNV | Missense_Mutation | novel | c.266G>A | p.Arg89Gln | p.R89Q | O43414 | protein_coding | tolerated_low_confidence(0.13) | benign(0.116) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ERI3 | SNV | Missense_Mutation | rs201922019 | c.167N>T | p.Ser56Leu | p.S56L | O43414 | protein_coding | tolerated_low_confidence(0.15) | benign(0) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| ERI3 | SNV | Missense_Mutation | rs779614935 | c.890G>A | p.Gly297Asp | p.G297D | O43414 | protein_coding | tolerated(0.58) | benign(0.094) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ERI3 | SNV | Missense_Mutation | c.350N>T | p.Ser117Phe | p.S117F | O43414 | protein_coding | deleterious(0) | possibly_damaging(0.601) | TCGA-AA-3675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ERI3 | SNV | Missense_Mutation | c.373G>A | p.Ala125Thr | p.A125T | O43414 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ERI3 | SNV | Missense_Mutation | c.427N>C | p.Tyr143His | p.Y143H | O43414 | protein_coding | deleterious(0) | benign(0.309) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ERI3 | SNV | Missense_Mutation | c.950N>T | p.Ala317Val | p.A317V | O43414 | protein_coding | tolerated(0.09) | possibly_damaging(0.851) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| ERI3 | SNV | Missense_Mutation | novel | c.388G>A | p.Ala130Thr | p.A130T | O43414 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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