Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ERG28

Gene summary for ERG28

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ERG28

Gene ID

11161

Gene nameergosterol biosynthesis 28 homolog
Gene AliasC14orf1
Cytomap14q24.3
Gene Typeprotein-coding
GO ID

GO:0006629

UniProtAcc

Q6FII3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11161ERG28S014HumanLiverHCC1.92e-591.88e+000.2254
11161ERG28S015HumanLiverHCC7.07e-562.06e+000.2375
11161ERG28S016HumanLiverHCC1.55e-661.86e+000.2243
11161ERG28S027HumanLiverHCC2.14e-116.46e-010.2446
11161ERG28S028HumanLiverHCC3.90e-328.27e-010.2503
11161ERG28S029HumanLiverHCC8.02e-401.21e+000.2581
11161ERG28male-WTAHumanThyroidPTC1.46e-364.61e-010.1037
11161ERG28female-WTAHumanThyroidPTC2.08e-022.38e-010.0726
11161ERG28nodule-WTAHumanThyroidgoiters1.25e-042.52e-010.0534
11161ERG28PTC01HumanThyroidPTC6.03e-407.57e-010.1899
11161ERG28PTC03HumanThyroidPTC9.50e-073.38e-010.1784
11161ERG28PTC04HumanThyroidPTC7.43e-163.47e-010.1927
11161ERG28PTC05HumanThyroidPTC3.34e-309.68e-010.2065
11161ERG28PTC06HumanThyroidPTC1.09e-489.55e-010.2057
11161ERG28PTC07HumanThyroidPTC5.60e-611.03e+000.2044
11161ERG28ATC08HumanThyroidATC8.31e-052.10e-010.0541
11161ERG28ATC11HumanThyroidATC1.60e-075.69e-010.3386
11161ERG28ATC12HumanThyroidATC4.25e-142.96e-010.34
11161ERG28ATC13HumanThyroidATC2.29e-021.17e-010.34
11161ERG28ATC2HumanThyroidATC4.44e-158.79e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0008202ColorectumADsteroid metabolic process85/3918319/187238.07e-034.75e-0285
GO:00161263EsophagusESCCsterol biosynthetic process46/855264/187231.91e-051.67e-0446
GO:00066946EsophagusESCCsteroid biosynthetic process98/8552173/187232.34e-031.03e-0298
GO:00161254EsophagusESCCsterol metabolic process86/8552152/187234.37e-031.73e-0286
GO:19016174EsophagusESCCorganic hydroxy compound biosynthetic process128/8552237/187235.86e-032.16e-02128
GO:00082022LiverHCCsteroid metabolic process188/7958319/187231.96e-095.63e-08188
GO:00161252LiverHCCsterol metabolic process101/7958152/187231.99e-095.63e-08101
GO:00161261LiverHCCsterol biosynthetic process47/795864/187235.00e-078.11e-0647
GO:00066942LiverHCCsteroid biosynthetic process104/7958173/187232.13e-062.91e-05104
GO:19016172LiverHCCorganic hydroxy compound biosynthetic process129/7958237/187231.32e-041.08e-03129
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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