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Gene: EPT1 |
Gene summary for EPT1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | EPT1 | Gene ID | 85465 |
| Gene name | selenoprotein I | |
| Gene Alias | EPT1 | |
| Cytomap | 2p23.3 | |
| Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9C0D9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 85465 | EPT1 | P28T-E | Human | Esophagus | ESCC | 2.42e-46 | 8.86e-01 | 0.1149 |
| 85465 | EPT1 | P30T-E | Human | Esophagus | ESCC | 2.38e-42 | 1.46e+00 | 0.137 |
| 85465 | EPT1 | P31T-E | Human | Esophagus | ESCC | 3.91e-21 | 3.66e-01 | 0.1251 |
| 85465 | EPT1 | P32T-E | Human | Esophagus | ESCC | 3.58e-27 | 5.12e-01 | 0.1666 |
| 85465 | EPT1 | P36T-E | Human | Esophagus | ESCC | 6.39e-26 | 8.77e-01 | 0.1187 |
| 85465 | EPT1 | P37T-E | Human | Esophagus | ESCC | 1.63e-22 | 4.60e-01 | 0.1371 |
| 85465 | EPT1 | P38T-E | Human | Esophagus | ESCC | 3.50e-03 | 1.66e-01 | 0.127 |
| 85465 | EPT1 | P39T-E | Human | Esophagus | ESCC | 1.98e-20 | 4.58e-01 | 0.0894 |
| 85465 | EPT1 | P40T-E | Human | Esophagus | ESCC | 5.34e-12 | 3.52e-01 | 0.109 |
| 85465 | EPT1 | P42T-E | Human | Esophagus | ESCC | 6.74e-37 | 7.97e-01 | 0.1175 |
| 85465 | EPT1 | P44T-E | Human | Esophagus | ESCC | 6.76e-08 | 2.89e-01 | 0.1096 |
| 85465 | EPT1 | P47T-E | Human | Esophagus | ESCC | 1.74e-21 | 4.32e-01 | 0.1067 |
| 85465 | EPT1 | P48T-E | Human | Esophagus | ESCC | 1.55e-23 | 4.85e-01 | 0.0959 |
| 85465 | EPT1 | P49T-E | Human | Esophagus | ESCC | 1.13e-15 | 1.77e+00 | 0.1768 |
| 85465 | EPT1 | P52T-E | Human | Esophagus | ESCC | 2.80e-38 | 7.55e-01 | 0.1555 |
| 85465 | EPT1 | P54T-E | Human | Esophagus | ESCC | 9.27e-21 | 4.66e-01 | 0.0975 |
| 85465 | EPT1 | P56T-E | Human | Esophagus | ESCC | 7.50e-06 | 6.17e-01 | 0.1613 |
| 85465 | EPT1 | P57T-E | Human | Esophagus | ESCC | 1.42e-13 | 3.35e-01 | 0.0926 |
| 85465 | EPT1 | P61T-E | Human | Esophagus | ESCC | 1.69e-20 | 3.89e-01 | 0.099 |
| 85465 | EPT1 | P62T-E | Human | Esophagus | ESCC | 1.14e-29 | 5.07e-01 | 0.1302 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
| GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
| GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
| GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
| GO:00066561 | Esophagus | ESCC | phosphatidylcholine biosynthetic process | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
| GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
| GO:0006646 | Esophagus | ESCC | phosphatidylethanolamine biosynthetic process | 10/8552 | 10/18723 | 3.94e-04 | 2.26e-03 | 10 |
| GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
| GO:00086543 | Oral cavity | OSCC | phospholipid biosynthetic process | 130/7305 | 253/18723 | 3.96e-05 | 3.46e-04 | 130 |
| GO:00464743 | Oral cavity | OSCC | glycerophospholipid biosynthetic process | 102/7305 | 211/18723 | 3.50e-03 | 1.48e-02 | 102 |
| GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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