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Gene: ENOSF1 |
Gene summary for ENOSF1 |
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Gene information | Species | Human | Gene symbol | ENOSF1 | Gene ID | 55556 |
Gene name | enolase superfamily member 1 | |
Gene Alias | FUCD | |
Cytomap | 18p11.32 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q7L5Y1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55556 | ENOSF1 | A015-C-006 | Human | Colorectum | FAP | 2.10e-18 | -3.25e-01 | -0.0994 |
55556 | ENOSF1 | A015-C-106 | Human | Colorectum | FAP | 8.06e-16 | -8.09e-02 | -0.0511 |
55556 | ENOSF1 | A002-C-114 | Human | Colorectum | FAP | 1.02e-22 | -3.77e-01 | -0.1561 |
55556 | ENOSF1 | A015-C-104 | Human | Colorectum | FAP | 6.54e-37 | -2.92e-01 | -0.1899 |
55556 | ENOSF1 | A001-C-014 | Human | Colorectum | FAP | 6.47e-21 | -3.28e-01 | 0.0135 |
55556 | ENOSF1 | A002-C-016 | Human | Colorectum | FAP | 7.30e-29 | -4.44e-01 | 0.0521 |
55556 | ENOSF1 | A015-C-002 | Human | Colorectum | FAP | 3.26e-16 | -5.09e-01 | -0.0763 |
55556 | ENOSF1 | A001-C-203 | Human | Colorectum | FAP | 9.48e-13 | -6.43e-02 | -0.0481 |
55556 | ENOSF1 | A002-C-116 | Human | Colorectum | FAP | 1.83e-37 | -3.85e-01 | -0.0452 |
55556 | ENOSF1 | A014-C-008 | Human | Colorectum | FAP | 3.06e-18 | -2.76e-01 | -0.191 |
55556 | ENOSF1 | A018-E-020 | Human | Colorectum | FAP | 1.77e-24 | -3.52e-01 | -0.2034 |
55556 | ENOSF1 | F034 | Human | Colorectum | FAP | 4.20e-26 | -2.51e-01 | -0.0665 |
55556 | ENOSF1 | F072B | Human | Colorectum | FAP | 6.95e-11 | -2.80e-01 | 0.257 |
55556 | ENOSF1 | CRC-1-8810 | Human | Colorectum | CRC | 6.10e-14 | -4.92e-01 | 0.6257 |
55556 | ENOSF1 | CRC-3-11773 | Human | Colorectum | CRC | 4.33e-21 | -5.66e-01 | 0.2564 |
55556 | ENOSF1 | LZE2T | Human | Esophagus | ESCC | 8.74e-16 | 1.83e+00 | 0.082 |
55556 | ENOSF1 | LZE4T | Human | Esophagus | ESCC | 8.14e-05 | 1.69e-01 | 0.0811 |
55556 | ENOSF1 | LZE7T | Human | Esophagus | ESCC | 3.06e-04 | 3.94e-01 | 0.0667 |
55556 | ENOSF1 | LZE8T | Human | Esophagus | ESCC | 6.67e-04 | 1.51e-01 | 0.067 |
55556 | ENOSF1 | LZE20T | Human | Esophagus | ESCC | 1.09e-03 | 5.95e-02 | 0.0662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0016052 | Colorectum | AD | carbohydrate catabolic process | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:00160522 | Colorectum | MSS | carbohydrate catabolic process | 45/3467 | 154/18723 | 7.93e-04 | 8.36e-03 | 45 |
GO:00442822 | Colorectum | MSS | small molecule catabolic process | 94/3467 | 376/18723 | 9.85e-04 | 9.86e-03 | 94 |
GO:00160542 | Colorectum | MSS | organic acid catabolic process | 61/3467 | 240/18723 | 4.72e-03 | 3.31e-02 | 61 |
GO:00160523 | Colorectum | FAP | carbohydrate catabolic process | 44/2622 | 154/18723 | 1.82e-06 | 7.42e-05 | 44 |
GO:00442621 | Colorectum | FAP | cellular carbohydrate metabolic process | 66/2622 | 283/18723 | 1.53e-05 | 4.01e-04 | 66 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:00160543 | Colorectum | FAP | organic acid catabolic process | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:00463951 | Colorectum | FAP | carboxylic acid catabolic process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
GO:00160524 | Colorectum | CRC | carbohydrate catabolic process | 34/2078 | 154/18723 | 6.37e-05 | 1.39e-03 | 34 |
GO:00442622 | Colorectum | CRC | cellular carbohydrate metabolic process | 49/2078 | 283/18723 | 1.06e-03 | 1.24e-02 | 49 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:001605216 | Esophagus | ESCC | carbohydrate catabolic process | 91/8552 | 154/18723 | 5.39e-04 | 2.97e-03 | 91 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:00442751 | Esophagus | ESCC | cellular carbohydrate catabolic process | 27/8552 | 40/18723 | 4.39e-03 | 1.73e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa000512 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
hsa0005111 | Esophagus | ESCC | Fructose and mannose metabolism | 24/4205 | 34/8465 | 1.09e-02 | 2.51e-02 | 1.29e-02 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENOSF1 | SNV | Missense_Mutation | rs763758268 | c.425N>T | p.Ala142Val | p.A142V | Q7L5Y1 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ENOSF1 | SNV | Missense_Mutation | novel | c.733G>T | p.Gly245Cys | p.G245C | Q7L5Y1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENOSF1 | SNV | Missense_Mutation | c.1317N>T | p.Glu439Asp | p.E439D | Q7L5Y1 | protein_coding | tolerated(0.37) | benign(0) | TCGA-D8-A27N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol+adriamycin+cyclophosphamide+herceptin | SD | |
ENOSF1 | SNV | Missense_Mutation | c.1327A>G | p.Lys443Glu | p.K443E | Q7L5Y1 | protein_coding | tolerated(0.42) | benign(0) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ENOSF1 | SNV | Missense_Mutation | novel | c.890N>G | p.Glu297Gly | p.E297G | Q7L5Y1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ENOSF1 | SNV | Missense_Mutation | c.197N>T | p.Ala66Val | p.A66V | Q7L5Y1 | protein_coding | tolerated(0.09) | benign(0.013) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENOSF1 | SNV | Missense_Mutation | c.424N>A | p.Ala142Thr | p.A142T | Q7L5Y1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ENOSF1 | SNV | Missense_Mutation | c.798N>T | p.Lys266Asn | p.K266N | Q7L5Y1 | protein_coding | tolerated(0.39) | benign(0.015) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENOSF1 | deletion | Frame_Shift_Del | novel | c.175delN | p.Tyr59MetfsTer4 | p.Y59Mfs*4 | Q7L5Y1 | protein_coding | TCGA-AG-A01J-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ENOSF1 | SNV | Missense_Mutation | novel | c.305N>C | p.Leu102Pro | p.L102P | Q7L5Y1 | protein_coding | deleterious(0.01) | benign(0.345) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55556 | ENOSF1 | ENZYME | fluorouracil | FLUOROURACIL | 17549067,27995989,20714149,27001118,23263912 | |
55556 | ENOSF1 | ENZYME | methotrexate | METHOTREXATE | 18322994,16130010 | |
55556 | ENOSF1 | ENZYME | capecitabine | CAPECITABINE | 17549067,27995989,20714149,27001118,23263912,28347776 | |
55556 | ENOSF1 | ENZYME | 3TC | LAMIVUDINE | 10864683 | |
55556 | ENOSF1 | ENZYME | AZT | ZIDOVUDINE | 15980332 | |
55556 | ENOSF1 | ENZYME | ANTIVIRAL | 12238529 |
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