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Gene: ELMOD2 |
Gene summary for ELMOD2 |
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Gene information | Species | Human | Gene symbol | ELMOD2 | Gene ID | 255520 |
Gene name | ELMO domain containing 2 | |
Gene Alias | 9830169G11Rik | |
Cytomap | 4q31.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8IZ81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
255520 | ELMOD2 | SYSMH2 | Human | Oral cavity | OSCC | 1.15e-03 | 1.28e-01 | 0.2326 |
255520 | ELMOD2 | SYSMH3 | Human | Oral cavity | OSCC | 4.48e-14 | 2.98e-01 | 0.2442 |
255520 | ELMOD2 | SYSMH5 | Human | Oral cavity | OSCC | 9.32e-07 | 8.61e-02 | 0.0647 |
255520 | ELMOD2 | SYSMH6 | Human | Oral cavity | OSCC | 1.30e-03 | 1.42e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:00028312 | Liver | HCC | regulation of response to biotic stimulus | 173/7958 | 327/18723 | 8.55e-05 | 7.48e-04 | 173 |
GO:0050688 | Liver | HCC | regulation of defense response to virus | 41/7958 | 69/18723 | 3.38e-03 | 1.54e-02 | 41 |
GO:000961515 | Oral cavity | OSCC | response to virus | 215/7305 | 367/18723 | 1.63e-14 | 9.41e-13 | 215 |
GO:00516074 | Oral cavity | OSCC | defense response to virus | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:01405464 | Oral cavity | OSCC | defense response to symbiont | 154/7305 | 265/18723 | 1.96e-10 | 5.63e-09 | 154 |
GO:00028317 | Oral cavity | OSCC | regulation of response to biotic stimulus | 177/7305 | 327/18723 | 1.73e-08 | 3.43e-07 | 177 |
GO:00506883 | Oral cavity | OSCC | regulation of defense response to virus | 42/7305 | 69/18723 | 1.92e-04 | 1.29e-03 | 42 |
GO:004308710 | Oral cavity | OSCC | regulation of GTPase activity | 165/7305 | 348/18723 | 7.94e-04 | 4.27e-03 | 165 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ELMOD2 | SNV | Missense_Mutation | c.106N>A | p.Asp36Asn | p.D36N | Q8IZ81 | protein_coding | tolerated(0.81) | benign(0.115) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ELMOD2 | SNV | Missense_Mutation | c.31N>T | p.Gly11Trp | p.G11W | Q8IZ81 | protein_coding | tolerated(0.2) | possibly_damaging(0.71) | TCGA-C5-A1ML-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ELMOD2 | SNV | Missense_Mutation | c.32N>T | p.Gly11Val | p.G11V | Q8IZ81 | protein_coding | tolerated(0.49) | benign(0.038) | TCGA-C5-A1ML-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ELMOD2 | SNV | Missense_Mutation | rs373389261 | c.422C>T | p.Thr141Met | p.T141M | Q8IZ81 | protein_coding | tolerated(0.07) | possibly_damaging(0.59) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ELMOD2 | SNV | Missense_Mutation | c.359N>G | p.Tyr120Cys | p.Y120C | Q8IZ81 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ELMOD2 | SNV | Missense_Mutation | novel | c.619G>A | p.Val207Ile | p.V207I | Q8IZ81 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ELMOD2 | SNV | Missense_Mutation | rs150918381 | c.98N>A | p.Arg33Gln | p.R33Q | Q8IZ81 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMOD2 | SNV | Missense_Mutation | novel | c.11N>A | p.Ser4Tyr | p.S4Y | Q8IZ81 | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMOD2 | SNV | Missense_Mutation | rs150918381 | c.98N>A | p.Arg33Gln | p.R33Q | Q8IZ81 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ELMOD2 | SNV | Missense_Mutation | rs375756274 | c.185N>T | p.Ala62Val | p.A62V | Q8IZ81 | protein_coding | tolerated(0.29) | possibly_damaging(0.829) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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