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Gene: EIF2S3 |
Gene summary for EIF2S3 |
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Gene information | Species | Human | Gene symbol | EIF2S3 | Gene ID | 1968 |
Gene name | eukaryotic translation initiation factor 2 subunit gamma | |
Gene Alias | EIF2 | |
Cytomap | Xp22.11 | |
Gene Type | protein-coding | GO ID | GO:0001731 | UniProtAcc | P41091 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1968 | EIF2S3 | EEC-subject1 | Human | Endometrium | EEC | 2.27e-08 | -2.18e-01 | -0.2682 |
1968 | EIF2S3 | EEC-subject2 | Human | Endometrium | EEC | 3.67e-10 | -3.06e-01 | -0.2607 |
1968 | EIF2S3 | EEC-subject3 | Human | Endometrium | EEC | 1.60e-30 | -3.10e-01 | -0.2525 |
1968 | EIF2S3 | EEC-subject4 | Human | Endometrium | EEC | 8.38e-04 | -2.11e-01 | -0.2571 |
1968 | EIF2S3 | EEC-subject5 | Human | Endometrium | EEC | 7.52e-05 | -2.69e-01 | -0.249 |
1968 | EIF2S3 | GSM5276934 | Human | Endometrium | EEC | 8.51e-04 | -2.62e-01 | -0.0913 |
1968 | EIF2S3 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.73e-31 | -2.93e-01 | -0.1869 |
1968 | EIF2S3 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 9.23e-31 | -4.04e-01 | -0.1875 |
1968 | EIF2S3 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.18e-38 | -3.11e-01 | -0.1883 |
1968 | EIF2S3 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.21e-31 | -2.54e-01 | -0.1934 |
1968 | EIF2S3 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.24e-50 | -1.55e-01 | -0.1917 |
1968 | EIF2S3 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.92e-49 | -1.63e-01 | -0.1916 |
1968 | EIF2S3 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.54e-07 | -1.73e-01 | -0.1269 |
1968 | EIF2S3 | LZE4T | Human | Esophagus | ESCC | 1.25e-19 | 7.64e-01 | 0.0811 |
1968 | EIF2S3 | LZE7T | Human | Esophagus | ESCC | 2.25e-06 | 7.94e-01 | 0.0667 |
1968 | EIF2S3 | LZE8T | Human | Esophagus | ESCC | 4.21e-22 | 1.27e+00 | 0.067 |
1968 | EIF2S3 | LZE20T | Human | Esophagus | ESCC | 1.60e-02 | 3.62e-01 | 0.0662 |
1968 | EIF2S3 | LZE22T | Human | Esophagus | ESCC | 4.56e-04 | 4.05e-01 | 0.068 |
1968 | EIF2S3 | LZE24D1 | Human | Esophagus | HGIN | 6.12e-03 | 3.37e-01 | 0.054 |
1968 | EIF2S3 | LZE24T | Human | Esophagus | ESCC | 2.56e-16 | 7.04e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0002183 | Colorectum | AD | cytoplasmic translational initiation | 21/3918 | 34/18723 | 2.73e-07 | 1.09e-05 | 21 |
GO:0006417 | Colorectum | AD | regulation of translation | 141/3918 | 468/18723 | 1.32e-06 | 4.22e-05 | 141 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0034250 | Colorectum | AD | positive regulation of cellular amide metabolic process | 53/3918 | 162/18723 | 2.98e-04 | 3.60e-03 | 53 |
GO:0045727 | Colorectum | AD | positive regulation of translation | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0001731 | Colorectum | AD | formation of translation preinitiation complex | 7/3918 | 11/18723 | 2.59e-03 | 1.96e-02 | 7 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00226181 | Colorectum | SER | ribonucleoprotein complex assembly | 69/2897 | 220/18723 | 2.25e-09 | 2.15e-07 | 69 |
GO:00718261 | Colorectum | SER | ribonucleoprotein complex subunit organization | 70/2897 | 227/18723 | 3.83e-09 | 3.51e-07 | 70 |
GO:00021831 | Colorectum | SER | cytoplasmic translational initiation | 18/2897 | 34/18723 | 4.42e-07 | 2.24e-05 | 18 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00064131 | Colorectum | SER | translational initiation | 36/2897 | 118/18723 | 2.84e-05 | 7.63e-04 | 36 |
GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
GO:00342501 | Colorectum | SER | positive regulation of cellular amide metabolic process | 41/2897 | 162/18723 | 7.67e-04 | 9.79e-03 | 41 |
GO:00457271 | Colorectum | SER | positive regulation of translation | 34/2897 | 136/18723 | 2.56e-03 | 2.37e-02 | 34 |
GO:00017311 | Colorectum | SER | formation of translation preinitiation complex | 6/2897 | 11/18723 | 3.12e-03 | 2.70e-02 | 6 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2S3 | SNV | Missense_Mutation | c.760C>A | p.Pro254Thr | p.P254T | P41091 | protein_coding | deleterious(0) | possibly_damaging(0.606) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | |
EIF2S3 | SNV | Missense_Mutation | c.757G>A | p.Glu253Lys | p.E253K | P41091 | protein_coding | tolerated(0.21) | benign(0) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
EIF2S3 | SNV | Missense_Mutation | c.1108N>A | p.Glu370Lys | p.E370K | P41091 | protein_coding | tolerated(0.09) | benign(0.019) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
EIF2S3 | SNV | Missense_Mutation | novel | c.521N>C | p.Leu174Pro | p.L174P | P41091 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF2S3 | SNV | Missense_Mutation | c.1189N>G | p.Lys397Glu | p.K397E | P41091 | protein_coding | deleterious(0.03) | possibly_damaging(0.772) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
EIF2S3 | SNV | Missense_Mutation | c.728T>C | p.Ile243Thr | p.I243T | P41091 | protein_coding | deleterious(0) | benign(0.182) | TCGA-AG-3885-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
EIF2S3 | SNV | Missense_Mutation | novel | c.1190A>G | p.Lys397Arg | p.K397R | P41091 | protein_coding | deleterious(0.05) | benign(0.151) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF2S3 | SNV | Missense_Mutation | c.1003N>A | p.Gly335Ser | p.G335S | P41091 | protein_coding | deleterious(0.05) | possibly_damaging(0.641) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EIF2S3 | insertion | Frame_Shift_Ins | novel | c.1321dupA | p.Ile441AsnfsTer4 | p.I441Nfs*4 | P41091 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EIF2S3 | SNV | Missense_Mutation | novel | c.311C>T | p.Ser104Phe | p.S104F | P41091 | protein_coding | deleterious(0.04) | possibly_damaging(0.786) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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