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Gene: EHD2 |
Gene summary for EHD2 |
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Gene information | Species | Human | Gene symbol | EHD2 | Gene ID | 30846 |
Gene name | EH domain containing 2 | |
Gene Alias | PAST2 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | A0A024R0S6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
30846 | EHD2 | P22T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.97e-01 | 0.1236 |
30846 | EHD2 | P23T-E | Human | Esophagus | ESCC | 3.32e-22 | 6.37e-01 | 0.108 |
30846 | EHD2 | P24T-E | Human | Esophagus | ESCC | 2.80e-26 | 6.09e-01 | 0.1287 |
30846 | EHD2 | P26T-E | Human | Esophagus | ESCC | 1.55e-28 | 5.51e-01 | 0.1276 |
30846 | EHD2 | P27T-E | Human | Esophagus | ESCC | 8.32e-13 | 2.65e-01 | 0.1055 |
30846 | EHD2 | P30T-E | Human | Esophagus | ESCC | 2.08e-12 | 5.29e-01 | 0.137 |
30846 | EHD2 | P31T-E | Human | Esophagus | ESCC | 6.48e-48 | 7.90e-01 | 0.1251 |
30846 | EHD2 | P32T-E | Human | Esophagus | ESCC | 6.92e-69 | 1.24e+00 | 0.1666 |
30846 | EHD2 | P36T-E | Human | Esophagus | ESCC | 1.65e-25 | 7.43e-01 | 0.1187 |
30846 | EHD2 | P37T-E | Human | Esophagus | ESCC | 8.01e-54 | 1.10e+00 | 0.1371 |
30846 | EHD2 | P38T-E | Human | Esophagus | ESCC | 1.64e-13 | 4.30e-01 | 0.127 |
30846 | EHD2 | P39T-E | Human | Esophagus | ESCC | 7.90e-04 | 9.50e-02 | 0.0894 |
30846 | EHD2 | P40T-E | Human | Esophagus | ESCC | 9.97e-18 | 3.58e-01 | 0.109 |
30846 | EHD2 | P42T-E | Human | Esophagus | ESCC | 3.32e-28 | 6.74e-01 | 0.1175 |
30846 | EHD2 | P44T-E | Human | Esophagus | ESCC | 6.95e-22 | 5.90e-01 | 0.1096 |
30846 | EHD2 | P47T-E | Human | Esophagus | ESCC | 1.37e-18 | 3.47e-01 | 0.1067 |
30846 | EHD2 | P48T-E | Human | Esophagus | ESCC | 2.52e-13 | 1.52e-01 | 0.0959 |
30846 | EHD2 | P49T-E | Human | Esophagus | ESCC | 4.52e-14 | 7.22e-01 | 0.1768 |
30846 | EHD2 | P52T-E | Human | Esophagus | ESCC | 1.41e-32 | 7.49e-01 | 0.1555 |
30846 | EHD2 | P54T-E | Human | Esophagus | ESCC | 8.92e-35 | 7.91e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:00324565 | Esophagus | ESCC | endocytic recycling | 51/8552 | 73/18723 | 2.47e-05 | 2.10e-04 | 51 |
GO:003086517 | Esophagus | ESCC | cortical cytoskeleton organization | 44/8552 | 61/18723 | 2.50e-05 | 2.13e-04 | 44 |
GO:003086610 | Esophagus | ESCC | cortical actin cytoskeleton organization | 28/8552 | 40/18723 | 1.61e-03 | 7.50e-03 | 28 |
GO:003238621 | Liver | HCC | regulation of intracellular transport | 231/7958 | 337/18723 | 1.99e-22 | 3.40e-20 | 231 |
GO:003238821 | Liver | HCC | positive regulation of intracellular transport | 148/7958 | 202/18723 | 5.15e-19 | 6.66e-17 | 148 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:009887621 | Liver | HCC | vesicle-mediated transport to the plasma membrane | 92/7958 | 136/18723 | 2.57e-09 | 7.07e-08 | 92 |
GO:003086512 | Liver | HCC | cortical cytoskeleton organization | 47/7958 | 61/18723 | 4.03e-08 | 8.69e-07 | 47 |
GO:003086612 | Liver | HCC | cortical actin cytoskeleton organization | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:00324562 | Liver | HCC | endocytic recycling | 48/7958 | 73/18723 | 5.07e-05 | 4.83e-04 | 48 |
GO:003238615 | Oral cavity | OSCC | regulation of intracellular transport | 218/7305 | 337/18723 | 6.91e-22 | 1.41e-19 | 218 |
GO:003238818 | Oral cavity | OSCC | positive regulation of intracellular transport | 134/7305 | 202/18723 | 2.82e-15 | 1.88e-13 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EHD2 | SNV | Missense_Mutation | c.666C>G | p.Asp222Glu | p.D222E | Q9NZN4 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EHD2 | SNV | Missense_Mutation | novel | c.1114N>T | p.His372Tyr | p.H372Y | Q9NZN4 | protein_coding | deleterious(0.03) | benign(0.396) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EHD2 | SNV | Missense_Mutation | novel | c.1525G>A | p.Ala509Thr | p.A509T | Q9NZN4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
EHD2 | SNV | Missense_Mutation | c.956C>T | p.Pro319Leu | p.P319L | Q9NZN4 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-C8-A12U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EHD2 | SNV | Missense_Mutation | rs146188664 | c.457N>A | p.Asp153Asn | p.D153N | Q9NZN4 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EHD2 | SNV | Missense_Mutation | rs772336133 | c.1321N>A | p.Glu441Lys | p.E441K | Q9NZN4 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
EHD2 | SNV | Missense_Mutation | novel | c.922N>A | p.Ala308Thr | p.A308T | Q9NZN4 | protein_coding | deleterious(0.01) | possibly_damaging(0.51) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
EHD2 | SNV | Missense_Mutation | novel | c.820G>A | p.Glu274Lys | p.E274K | Q9NZN4 | protein_coding | deleterious(0) | benign(0.327) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EHD2 | SNV | Missense_Mutation | c.608N>A | p.Ala203Asp | p.A203D | Q9NZN4 | protein_coding | deleterious(0) | possibly_damaging(0.616) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EHD2 | SNV | Missense_Mutation | c.865G>A | p.Ala289Thr | p.A289T | Q9NZN4 | protein_coding | deleterious(0.03) | benign(0.135) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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