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Gene: EAPP |
Gene summary for EAPP |
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Gene information | Species | Human | Gene symbol | EAPP | Gene ID | 55837 |
Gene name | E2F associated phosphoprotein | |
Gene Alias | BM036 | |
Cytomap | 14q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q56P03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55837 | EAPP | A014-C-008 | Human | Colorectum | FAP | 1.12e-03 | -2.15e-01 | -0.191 |
55837 | EAPP | A018-E-020 | Human | Colorectum | FAP | 2.52e-05 | -2.34e-01 | -0.2034 |
55837 | EAPP | F034 | Human | Colorectum | FAP | 2.29e-09 | -2.01e-01 | -0.0665 |
55837 | EAPP | LZE2T | Human | Esophagus | ESCC | 2.65e-06 | 5.89e-01 | 0.082 |
55837 | EAPP | LZE3D | Human | Esophagus | HGIN | 1.39e-02 | 4.37e-01 | 0.0668 |
55837 | EAPP | LZE4T | Human | Esophagus | ESCC | 5.73e-29 | 9.19e-01 | 0.0811 |
55837 | EAPP | LZE5T | Human | Esophagus | ESCC | 4.71e-10 | 1.07e+00 | 0.0514 |
55837 | EAPP | LZE7T | Human | Esophagus | ESCC | 2.55e-05 | 4.99e-01 | 0.0667 |
55837 | EAPP | LZE8T | Human | Esophagus | ESCC | 2.69e-14 | 3.14e-01 | 0.067 |
55837 | EAPP | LZE20T | Human | Esophagus | ESCC | 1.04e-04 | 4.12e-01 | 0.0662 |
55837 | EAPP | LZE22T | Human | Esophagus | ESCC | 1.80e-06 | 8.00e-01 | 0.068 |
55837 | EAPP | LZE24T | Human | Esophagus | ESCC | 1.16e-22 | 7.79e-01 | 0.0596 |
55837 | EAPP | LZE6T | Human | Esophagus | ESCC | 1.70e-07 | 3.30e-01 | 0.0845 |
55837 | EAPP | P1T-E | Human | Esophagus | ESCC | 4.45e-07 | 7.39e-01 | 0.0875 |
55837 | EAPP | P2T-E | Human | Esophagus | ESCC | 1.41e-58 | 8.08e-01 | 0.1177 |
55837 | EAPP | P4T-E | Human | Esophagus | ESCC | 1.62e-25 | 7.14e-01 | 0.1323 |
55837 | EAPP | P5T-E | Human | Esophagus | ESCC | 3.89e-35 | 7.05e-01 | 0.1327 |
55837 | EAPP | P8T-E | Human | Esophagus | ESCC | 6.56e-87 | 1.72e+00 | 0.0889 |
55837 | EAPP | P9T-E | Human | Esophagus | ESCC | 1.38e-22 | 5.82e-01 | 0.1131 |
55837 | EAPP | P10T-E | Human | Esophagus | ESCC | 1.19e-40 | 8.28e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:0006368 | Colorectum | AD | transcription elongation from RNA polymerase II promoter | 24/3918 | 69/18723 | 5.35e-03 | 3.52e-02 | 24 |
GO:00063541 | Colorectum | MSS | DNA-templated transcription, elongation | 29/3467 | 91/18723 | 1.52e-03 | 1.39e-02 | 29 |
GO:00327861 | Colorectum | MSS | positive regulation of DNA-templated transcription, elongation | 12/3467 | 27/18723 | 1.74e-03 | 1.55e-02 | 12 |
GO:00063681 | Colorectum | MSS | transcription elongation from RNA polymerase II promoter | 22/3467 | 69/18723 | 5.31e-03 | 3.62e-02 | 22 |
GO:00327862 | Colorectum | FAP | positive regulation of DNA-templated transcription, elongation | 11/2622 | 27/18723 | 5.93e-04 | 6.58e-03 | 11 |
GO:00063682 | Colorectum | FAP | transcription elongation from RNA polymerase II promoter | 20/2622 | 69/18723 | 9.25e-04 | 9.26e-03 | 20 |
GO:00063542 | Colorectum | FAP | DNA-templated transcription, elongation | 24/2622 | 91/18723 | 1.32e-03 | 1.22e-02 | 24 |
GO:0032968 | Colorectum | FAP | positive regulation of transcription elongation from RNA polymerase II promoter | 6/2622 | 13/18723 | 5.32e-03 | 3.49e-02 | 6 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:003278412 | Esophagus | ESCC | regulation of DNA-templated transcription, elongation | 45/8552 | 53/18723 | 3.64e-09 | 7.61e-08 | 45 |
GO:003424312 | Esophagus | ESCC | regulation of transcription elongation from RNA polymerase II promoter | 28/8552 | 32/18723 | 1.02e-06 | 1.29e-05 | 28 |
GO:003278613 | Esophagus | ESCC | positive regulation of DNA-templated transcription, elongation | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:003296812 | Esophagus | ESCC | positive regulation of transcription elongation from RNA polymerase II promoter | 12/8552 | 13/18723 | 6.18e-04 | 3.32e-03 | 12 |
GO:003424411 | Esophagus | ESCC | negative regulation of transcription elongation from RNA polymerase II promoter | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:003278511 | Esophagus | ESCC | negative regulation of DNA-templated transcription, elongation | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00063544 | Liver | Cirrhotic | DNA-templated transcription, elongation | 35/4634 | 91/18723 | 2.56e-03 | 1.53e-02 | 35 |
GO:00063683 | Liver | Cirrhotic | transcription elongation from RNA polymerase II promoter | 28/4634 | 69/18723 | 2.70e-03 | 1.58e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EAPP | SNV | Missense_Mutation | c.445G>A | p.Ala149Thr | p.A149T | Q56P03 | protein_coding | tolerated(0.21) | possibly_damaging(0.597) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EAPP | SNV | Missense_Mutation | c.646G>A | p.Glu216Lys | p.E216K | Q56P03 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
EAPP | insertion | Frame_Shift_Ins | novel | c.374_375insA | p.Lys126GlufsTer10 | p.K126Efs*10 | Q56P03 | protein_coding | TCGA-UL-AAZ6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | herceptin | SD | ||
EAPP | SNV | Missense_Mutation | novel | c.310N>T | p.Asp104Tyr | p.D104Y | Q56P03 | protein_coding | deleterious(0) | possibly_damaging(0.653) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
EAPP | SNV | Missense_Mutation | rs149923274 | c.836N>G | p.Asn279Ser | p.N279S | Q56P03 | protein_coding | deleterious(0.04) | benign(0.076) | TCGA-AA-A03F-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
EAPP | SNV | Missense_Mutation | c.347N>T | p.Arg116Ile | p.R116I | Q56P03 | protein_coding | tolerated(0.05) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EAPP | SNV | Missense_Mutation | c.800N>T | p.Ala267Val | p.A267V | Q56P03 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EAPP | SNV | Missense_Mutation | c.437N>A | p.Arg146Lys | p.R146K | Q56P03 | protein_coding | tolerated(0.19) | benign(0.026) | TCGA-AG-4007-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
EAPP | SNV | Missense_Mutation | c.710C>A | p.Ser237Tyr | p.S237Y | Q56P03 | protein_coding | tolerated(0.12) | benign(0.34) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EAPP | deletion | Frame_Shift_Del | novel | c.833delN | p.Phe278SerfsTer4 | p.F278Sfs*4 | Q56P03 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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