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Gene: DUSP4 |
Gene summary for DUSP4 |
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Gene information | Species | Human | Gene symbol | DUSP4 | Gene ID | 1846 |
Gene name | dual specificity phosphatase 4 | |
Gene Alias | HVH2 | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q13115 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1846 | DUSP4 | P4T-E | Human | Esophagus | ESCC | 1.48e-05 | -1.07e-01 | 0.1323 |
1846 | DUSP4 | P5T-E | Human | Esophagus | ESCC | 1.08e-05 | -3.55e-01 | 0.1327 |
1846 | DUSP4 | P8T-E | Human | Esophagus | ESCC | 1.71e-13 | 2.68e-01 | 0.0889 |
1846 | DUSP4 | P10T-E | Human | Esophagus | ESCC | 6.46e-03 | -2.72e-01 | 0.116 |
1846 | DUSP4 | P16T-E | Human | Esophagus | ESCC | 1.66e-09 | 1.68e-01 | 0.1153 |
1846 | DUSP4 | P20T-E | Human | Esophagus | ESCC | 1.55e-05 | -3.73e-01 | 0.1124 |
1846 | DUSP4 | P22T-E | Human | Esophagus | ESCC | 1.32e-04 | -1.77e-01 | 0.1236 |
1846 | DUSP4 | P26T-E | Human | Esophagus | ESCC | 1.32e-03 | -3.38e-01 | 0.1276 |
1846 | DUSP4 | P28T-E | Human | Esophagus | ESCC | 7.12e-07 | -2.62e-01 | 0.1149 |
1846 | DUSP4 | P32T-E | Human | Esophagus | ESCC | 4.23e-07 | -3.53e-01 | 0.1666 |
1846 | DUSP4 | P39T-E | Human | Esophagus | ESCC | 3.54e-10 | -2.78e-01 | 0.0894 |
1846 | DUSP4 | P52T-E | Human | Esophagus | ESCC | 1.85e-07 | -3.06e-01 | 0.1555 |
1846 | DUSP4 | P54T-E | Human | Esophagus | ESCC | 5.82e-05 | -3.27e-01 | 0.0975 |
1846 | DUSP4 | P57T-E | Human | Esophagus | ESCC | 2.88e-07 | 4.93e-01 | 0.0926 |
1846 | DUSP4 | P61T-E | Human | Esophagus | ESCC | 6.53e-03 | 1.20e-01 | 0.099 |
1846 | DUSP4 | P75T-E | Human | Esophagus | ESCC | 2.82e-15 | 7.61e-01 | 0.1125 |
1846 | DUSP4 | P76T-E | Human | Esophagus | ESCC | 5.27e-16 | 7.71e-01 | 0.1207 |
1846 | DUSP4 | P82T-E | Human | Esophagus | ESCC | 1.32e-06 | 1.22e+00 | 0.1072 |
1846 | DUSP4 | P83T-E | Human | Esophagus | ESCC | 2.38e-03 | -3.01e-01 | 0.1738 |
1846 | DUSP4 | P127T-E | Human | Esophagus | ESCC | 8.48e-09 | -2.22e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00703713 | Breast | IDC | ERK1 and ERK2 cascade | 43/1434 | 330/18723 | 4.28e-04 | 5.84e-03 | 43 |
GO:00703733 | Breast | IDC | negative regulation of ERK1 and ERK2 cascade | 14/1434 | 78/18723 | 2.21e-03 | 2.06e-02 | 14 |
GO:00703722 | Breast | IDC | regulation of ERK1 and ERK2 cascade | 37/1434 | 309/18723 | 4.53e-03 | 3.49e-02 | 37 |
GO:007037111 | Breast | DCIS | ERK1 and ERK2 cascade | 41/1390 | 330/18723 | 8.11e-04 | 9.32e-03 | 41 |
GO:007037311 | Breast | DCIS | negative regulation of ERK1 and ERK2 cascade | 14/1390 | 78/18723 | 1.65e-03 | 1.64e-02 | 14 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:00073698 | Esophagus | ESCC | gastrulation | 115/8552 | 185/18723 | 4.35e-06 | 4.64e-05 | 115 |
GO:00074926 | Esophagus | ESCC | endoderm development | 54/8552 | 77/18723 | 1.20e-05 | 1.12e-04 | 54 |
GO:00017064 | Esophagus | ESCC | endoderm formation | 38/8552 | 54/18723 | 2.08e-04 | 1.31e-03 | 38 |
GO:00017044 | Esophagus | ESCC | formation of primary germ layer | 75/8552 | 121/18723 | 2.17e-04 | 1.36e-03 | 75 |
GO:0043409110 | Esophagus | ESCC | negative regulation of MAPK cascade | 105/8552 | 180/18723 | 4.13e-04 | 2.35e-03 | 105 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
GO:004340917 | Oral cavity | OSCC | negative regulation of MAPK cascade | 105/7305 | 180/18723 | 1.10e-07 | 1.87e-06 | 105 |
GO:00074925 | Oral cavity | OSCC | endoderm development | 47/7305 | 77/18723 | 7.40e-05 | 5.81e-04 | 47 |
GO:00017063 | Oral cavity | OSCC | endoderm formation | 34/7305 | 54/18723 | 3.12e-04 | 1.94e-03 | 34 |
GO:00073697 | Oral cavity | OSCC | gastrulation | 95/7305 | 185/18723 | 4.17e-04 | 2.54e-03 | 95 |
GO:00017043 | Oral cavity | OSCC | formation of primary germ layer | 65/7305 | 121/18723 | 7.08e-04 | 3.90e-03 | 65 |
GO:00703735 | Oral cavity | OSCC | negative regulation of ERK1 and ERK2 cascade | 43/7305 | 78/18723 | 2.80e-03 | 1.22e-02 | 43 |
GO:00703716 | Oral cavity | OSCC | ERK1 and ERK2 cascade | 150/7305 | 330/18723 | 9.47e-03 | 3.38e-02 | 150 |
GO:00703724 | Oral cavity | OSCC | regulation of ERK1 and ERK2 cascade | 140/7305 | 309/18723 | 1.34e-02 | 4.46e-02 | 140 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DUSP4 | SNV | Missense_Mutation | novel | c.1181N>C | p.Cys394Ser | p.C394S | Q13115 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DUSP4 | SNV | Missense_Mutation | novel | c.719N>T | p.Tyr240Phe | p.Y240F | Q13115 | protein_coding | tolerated(0.35) | benign(0.232) | TCGA-E2-A573-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
DUSP4 | insertion | Nonsense_Mutation | novel | c.985_986insGACGAGGCCAGCCAGAATGGCAATAAGGACTCCGAAT | p.Gln329ArgfsTer9 | p.Q329Rfs*9 | Q13115 | protein_coding | TCGA-A8-A0A2-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
DUSP4 | SNV | Missense_Mutation | rs375453930 | c.823N>T | p.Arg275Cys | p.R275C | Q13115 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DUSP4 | SNV | Missense_Mutation | c.662N>T | p.Gly221Val | p.G221V | Q13115 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6648-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD | |
DUSP4 | SNV | Missense_Mutation | rs375453930 | c.823C>T | p.Arg275Cys | p.R275C | Q13115 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DUSP4 | SNV | Missense_Mutation | rs774219516 | c.471C>A | p.Phe157Leu | p.F157L | Q13115 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DUSP4 | SNV | Missense_Mutation | novel | c.450T>G | p.Phe150Leu | p.F150L | Q13115 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
DUSP4 | SNV | Missense_Mutation | rs375453930 | c.823N>T | p.Arg275Cys | p.R275C | Q13115 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
DUSP4 | SNV | Missense_Mutation | c.62G>A | p.Arg21Gln | p.R21Q | Q13115 | protein_coding | tolerated(0.26) | benign(0.072) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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