![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DOPEY2 |
Gene summary for DOPEY2 |
![]() |
Gene information | Species | Human | Gene symbol | DOPEY2 | Gene ID | 9980 |
Gene name | DOP1 leucine zipper like protein B | |
Gene Alias | 21orf5 | |
Cytomap | 21q22.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y3R5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9980 | DOPEY2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.46e-04 | -7.05e-01 | 0.0446 |
9980 | DOPEY2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 8.06e-03 | -7.05e-01 | 0.0451 |
9980 | DOPEY2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.91e-07 | -7.05e-01 | 0.0528 |
9980 | DOPEY2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.44e-05 | -7.05e-01 | 0.0131 |
9980 | DOPEY2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.85e-08 | -7.05e-01 | -0.0177 |
9980 | DOPEY2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.11e-03 | -7.05e-01 | 0.0171 |
9980 | DOPEY2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.47e-17 | -7.05e-01 | 0.0338 |
9980 | DOPEY2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.22e-41 | -7.05e-01 | 0.0674 |
9980 | DOPEY2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.37e-08 | -7.05e-01 | 0.0112 |
9980 | DOPEY2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.53e-13 | -7.05e-01 | 0.0588 |
9980 | DOPEY2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.04e-06 | -3.25e-01 | 0.294 |
9980 | DOPEY2 | A015-C-203 | Human | Colorectum | FAP | 8.66e-25 | -3.50e-01 | -0.1294 |
9980 | DOPEY2 | A015-C-204 | Human | Colorectum | FAP | 2.95e-05 | -3.23e-01 | -0.0228 |
9980 | DOPEY2 | A002-C-201 | Human | Colorectum | FAP | 2.15e-09 | -2.67e-01 | 0.0324 |
9980 | DOPEY2 | A002-C-203 | Human | Colorectum | FAP | 1.18e-02 | -1.75e-01 | 0.2786 |
9980 | DOPEY2 | A001-C-119 | Human | Colorectum | FAP | 2.47e-04 | -8.39e-02 | -0.1557 |
9980 | DOPEY2 | A001-C-108 | Human | Colorectum | FAP | 6.23e-11 | -9.87e-02 | -0.0272 |
9980 | DOPEY2 | A002-C-205 | Human | Colorectum | FAP | 1.52e-17 | -2.02e-01 | -0.1236 |
9980 | DOPEY2 | A015-C-006 | Human | Colorectum | FAP | 5.49e-14 | -2.76e-01 | -0.0994 |
9980 | DOPEY2 | A015-C-106 | Human | Colorectum | FAP | 4.45e-05 | -8.89e-02 | -0.0511 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY2 | SNV | Missense_Mutation | novel | c.6487C>A | p.Pro2163Thr | p.P2163T | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.5416C>G | p.Leu1806Val | p.L1806V | Q9Y3R5 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.4835N>G | p.Asn1612Ser | p.N1612S | Q9Y3R5 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | c.5017N>G | p.Leu1673Val | p.L1673V | Q9Y3R5 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.262N>C | p.Glu88Gln | p.E88Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.6664N>A | p.Glu2222Lys | p.E2222K | Q9Y3R5 | protein_coding | tolerated(0.57) | benign(0.033) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | novel | c.404C>A | p.Pro135Gln | p.P135Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
DOPEY2 | insertion | Nonsense_Mutation | novel | c.6452_6453insCATTTGATAATACTTACTAGTTTTTTAT | p.Ala2152IlefsTer2 | p.A2152Ifs*2 | Q9Y3R5 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DOPEY2 | insertion | Nonsense_Mutation | novel | c.4966_4967insCGCAAATGCATATGCAAATGCATGTATATAATTAAC | p.Gly1656delinsAlaGlnMetHisMetGlnMetHisValTyrAsnTerArg | p.G1656delinsAQMHMQMHVYN*R | Q9Y3R5 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DOPEY2 | insertion | In_Frame_Ins | novel | c.2865_2866insACTCTGGTTTGGGTGACAGAGCAAGACTCCGTCTCAAAAAATAAA | p.Arg955_Ser956insThrLeuValTrpValThrGluGlnAspSerValSerLysAsnLys | p.R955_S956insTLVWVTEQDSVSKNK | Q9Y3R5 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |