Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: DNM2

Gene summary for DNM2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

DNM2

Gene ID

1785

Gene namedynamin 2
Gene AliasCMT2M
Cytomap19p13.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P50570


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1785DNM2A002-C-201HumanColorectumFAP2.21e-14-1.65e-010.0324
1785DNM2A002-C-203HumanColorectumFAP8.44e-03-1.43e-010.2786
1785DNM2A001-C-119HumanColorectumFAP4.62e-08-2.61e-01-0.1557
1785DNM2A001-C-108HumanColorectumFAP3.01e-20-1.81e-01-0.0272
1785DNM2A002-C-205HumanColorectumFAP8.02e-27-3.14e-01-0.1236
1785DNM2A001-C-104HumanColorectumFAP5.25e-03-5.42e-020.0184
1785DNM2A015-C-005HumanColorectumFAP1.81e-03-9.89e-02-0.0336
1785DNM2A015-C-006HumanColorectumFAP3.94e-24-5.69e-01-0.0994
1785DNM2A015-C-106HumanColorectumFAP6.20e-13-1.78e-01-0.0511
1785DNM2A002-C-114HumanColorectumFAP4.63e-23-2.26e-01-0.1561
1785DNM2A015-C-104HumanColorectumFAP8.22e-38-1.69e-01-0.1899
1785DNM2A001-C-014HumanColorectumFAP3.40e-18-3.14e-010.0135
1785DNM2A002-C-016HumanColorectumFAP1.07e-30-4.29e-010.0521
1785DNM2A015-C-002HumanColorectumFAP1.64e-13-3.36e-01-0.0763
1785DNM2A001-C-007HumanColorectumCRC3.79e-02-3.80e-010.1899
1785DNM2A001-C-203HumanColorectumFAP8.48e-14-1.47e-01-0.0481
1785DNM2A002-C-116HumanColorectumFAP1.94e-47-4.48e-01-0.0452
1785DNM2A014-C-008HumanColorectumFAP7.31e-17-1.66e-01-0.191
1785DNM2A018-E-020HumanColorectumFAP2.94e-25-3.58e-01-0.2034
1785DNM2F034HumanColorectumFAP7.39e-28-3.09e-01-0.0665
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0032535ColorectumADregulation of cellular component size142/3918383/187231.74e-133.41e-11142
GO:0048193ColorectumADGolgi vesicle transport109/3918296/187231.80e-101.68e-08109
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0022604ColorectumADregulation of cell morphogenesis109/3918309/187233.08e-092.07e-07109
GO:0010811ColorectumADpositive regulation of cell-substrate adhesion53/3918123/187232.30e-081.27e-0653
GO:0098876ColorectumADvesicle-mediated transport to the plasma membrane57/3918136/187232.30e-081.27e-0657
GO:0010810ColorectumADregulation of cell-substrate adhesion81/3918221/187234.80e-082.55e-0681
GO:0010639ColorectumADnegative regulation of organelle organization114/3918348/187231.41e-076.49e-06114
GO:0006892ColorectumADpost-Golgi vesicle-mediated transport45/3918104/187232.22e-079.26e-0645
GO:0031589ColorectumADcell-substrate adhesion116/3918363/187234.68e-071.76e-05116
GO:0043112ColorectumADreceptor metabolic process62/3918166/187238.18e-072.85e-0562
GO:0016049ColorectumADcell growth143/3918482/187232.83e-068.09e-05143
GO:0072583ColorectumADclathrin-dependent endocytosis24/391847/187234.60e-061.22e-0424
GO:0001558ColorectumADregulation of cell growth124/3918414/187237.67e-061.86e-04124
GO:0007265ColorectumADRas protein signal transduction104/3918337/187231.01e-052.35e-04104
GO:0051650ColorectumADestablishment of vesicle localization57/3918161/187231.47e-053.15e-0457
GO:0051056ColorectumADregulation of small GTPase mediated signal transduction94/3918302/187231.81e-053.76e-0494
GO:0006893ColorectumADGolgi to plasma membrane transport27/391860/187232.41e-054.66e-0427
GO:1902743ColorectumADregulation of lamellipodium organization25/391854/187232.63e-055.01e-0425
GO:0002028ColorectumADregulation of sodium ion transport36/391890/187232.89e-055.37e-0436
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04144ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa05100ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa04666ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa04961ColorectumADEndocrine and other factor-regulated calcium reabsorption24/209253/84658.49e-045.93e-033.78e-0324
hsa041441ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa051001ColorectumADBacterial invasion of epithelial cells44/209277/84651.13e-092.22e-081.42e-0844
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa046661ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa049611ColorectumADEndocrine and other factor-regulated calcium reabsorption24/209253/84658.49e-045.93e-033.78e-0324
hsa051002ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa041442ColorectumSEREndocytosis81/1580251/84651.14e-072.36e-061.71e-0681
hsa046662ColorectumSERFc gamma R-mediated phagocytosis39/158097/84655.84e-079.70e-067.04e-0639
hsa051322ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa049612ColorectumSEREndocrine and other factor-regulated calcium reabsorption19/158053/84652.32e-031.75e-021.27e-0219
hsa051003ColorectumSERBacterial invasion of epithelial cells36/158077/84651.56e-083.45e-072.50e-0736
hsa041443ColorectumSEREndocytosis81/1580251/84651.14e-072.36e-061.71e-0681
hsa046663ColorectumSERFc gamma R-mediated phagocytosis39/158097/84655.84e-079.70e-067.04e-0639
hsa051323ColorectumSERSalmonella infection77/1580249/84651.56e-062.35e-051.71e-0577
hsa049613ColorectumSEREndocrine and other factor-regulated calcium reabsorption19/158053/84652.32e-031.75e-021.27e-0219
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
DNM2SNVMissense_Mutationnovelc.1285N>Cp.Asp429Hisp.D429HP50570protein_codingdeleterious(0)probably_damaging(1)TCGA-AC-A2QI-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanCR
DNM2SNVMissense_Mutationnovelc.873N>Tp.Glu291Aspp.E291DP50570protein_codingtolerated(1)benign(0.007)TCGA-E9-A1RF-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapytamoxiphenSD
DNM2insertionFrame_Shift_Insnovelc.1822_1823insTGCCCAGCCAAAACTTTTTTTATAAAAAp.Asp608ValfsTer116p.D608Vfs*116P50570protein_codingTCGA-A2-A0CX-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
DNM2SNVMissense_Mutationnovelc.646N>Ap.Ala216Thrp.A216TP50570protein_codingdeleterious(0)probably_damaging(0.999)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationnovelc.2509N>Tp.Arg837Trpp.R837WP50570protein_codingdeleterious_low_confidence(0)possibly_damaging(0.639)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationc.1584N>Gp.Ile528Metp.I528MP50570protein_codingdeleterious(0.03)possibly_damaging(0.766)TCGA-C5-A1BQ-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
DNM2SNVMissense_Mutationnovelc.766N>Gp.Arg256Glyp.R256GP50570protein_codingdeleterious(0.01)probably_damaging(0.997)TCGA-VS-A9UO-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationnovelc.767N>Cp.Arg256Thrp.R256TP50570protein_codingtolerated(0.06)probably_damaging(0.997)TCGA-VS-A9UO-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
DNM2SNVMissense_Mutationc.886N>Ap.Leu296Ilep.L296IP50570protein_codingtolerated(0.2)possibly_damaging(0.823)TCGA-A6-5661-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
DNM2SNVMissense_Mutationrs749953105c.2170C>Tp.Arg724Cysp.R724CP50570protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AA-3864-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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