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Gene: DMAC2L |
Gene summary for DMAC2L |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DMAC2L | Gene ID | 27109 |
| Gene name | distal membrane arm assembly component 2 like | |
| Gene Alias | ATP5S | |
| Cytomap | 14q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q99766 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 27109 | DMAC2L | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.29e-03 | 2.31e-01 | 0.0131 |
| 27109 | DMAC2L | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.46e-07 | 3.17e-01 | -0.0177 |
| 27109 | DMAC2L | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.19e-07 | 4.15e-01 | 0.0171 |
| 27109 | DMAC2L | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.49e-10 | 2.58e-01 | 0.0338 |
| 27109 | DMAC2L | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.28e-10 | 2.13e-01 | 0.0674 |
| 27109 | DMAC2L | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.45e-04 | 3.74e-01 | -0.0124 |
| 27109 | DMAC2L | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.15e-02 | 1.58e-01 | 0.0588 |
| 27109 | DMAC2L | LZE2T | Human | Esophagus | ESCC | 3.94e-07 | 7.37e-01 | 0.082 |
| 27109 | DMAC2L | LZE4T | Human | Esophagus | ESCC | 6.29e-20 | 5.07e-01 | 0.0811 |
| 27109 | DMAC2L | LZE5T | Human | Esophagus | ESCC | 1.15e-08 | 4.66e-01 | 0.0514 |
| 27109 | DMAC2L | LZE8T | Human | Esophagus | ESCC | 4.41e-02 | 1.10e-01 | 0.067 |
| 27109 | DMAC2L | LZE20T | Human | Esophagus | ESCC | 3.61e-13 | 3.51e-01 | 0.0662 |
| 27109 | DMAC2L | LZE22D1 | Human | Esophagus | HGIN | 3.26e-02 | 1.82e-01 | 0.0595 |
| 27109 | DMAC2L | LZE22T | Human | Esophagus | ESCC | 1.54e-04 | 3.36e-01 | 0.068 |
| 27109 | DMAC2L | LZE24T | Human | Esophagus | ESCC | 4.28e-25 | 5.18e-01 | 0.0596 |
| 27109 | DMAC2L | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 1.82e-01 | 0.0655 |
| 27109 | DMAC2L | LZE6T | Human | Esophagus | ESCC | 1.62e-02 | 1.39e-01 | 0.0845 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
| GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
| GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
| GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
| GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
| GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
| GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
| GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
| GO:1902600 | Colorectum | AD | proton transmembrane transport | 66/3918 | 157/18723 | 1.59e-09 | 1.17e-07 | 66 |
| GO:0009144 | Colorectum | AD | purine nucleoside triphosphate metabolic process | 43/3918 | 88/18723 | 5.05e-09 | 3.19e-07 | 43 |
| GO:0009205 | Colorectum | AD | purine ribonucleoside triphosphate metabolic process | 39/3918 | 82/18723 | 6.58e-08 | 3.40e-06 | 39 |
| GO:0009141 | Colorectum | AD | nucleoside triphosphate metabolic process | 48/3918 | 112/18723 | 1.27e-07 | 6.02e-06 | 48 |
| GO:0006754 | Colorectum | AD | ATP biosynthetic process | 30/3918 | 57/18723 | 1.27e-07 | 6.02e-06 | 30 |
| GO:0009145 | Colorectum | AD | purine nucleoside triphosphate biosynthetic process | 34/3918 | 69/18723 | 1.54e-07 | 6.78e-06 | 34 |
| GO:0009199 | Colorectum | AD | ribonucleoside triphosphate metabolic process | 40/3918 | 89/18723 | 3.04e-07 | 1.21e-05 | 40 |
| GO:0009152 | Colorectum | AD | purine ribonucleotide biosynthetic process | 64/3918 | 169/18723 | 3.09e-07 | 1.22e-05 | 64 |
| GO:0009206 | Colorectum | AD | purine ribonucleoside triphosphate biosynthetic process | 33/3918 | 68/18723 | 3.68e-07 | 1.43e-05 | 33 |
| GO:0009201 | Colorectum | AD | ribonucleoside triphosphate biosynthetic process | 34/3918 | 74/18723 | 1.23e-06 | 4.01e-05 | 34 |
| GO:0009260 | Colorectum | AD | ribonucleotide biosynthetic process | 66/3918 | 182/18723 | 1.25e-06 | 4.02e-05 | 66 |
| GO:0009142 | Colorectum | AD | nucleoside triphosphate biosynthetic process | 37/3918 | 85/18723 | 2.16e-06 | 6.35e-05 | 37 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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