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Gene: DDX18 |
Gene summary for DDX18 |
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Gene information | Species | Human | Gene symbol | DDX18 | Gene ID | 8886 |
Gene name | DEAD-box helicase 18 | |
Gene Alias | Has1 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000463 | UniProtAcc | A0A024RAH8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8886 | DDX18 | A015-C-002 | Human | Colorectum | FAP | 1.16e-05 | 4.58e-02 | -0.0763 |
8886 | DDX18 | A001-C-203 | Human | Colorectum | FAP | 1.73e-06 | -6.33e-02 | -0.0481 |
8886 | DDX18 | A002-C-116 | Human | Colorectum | FAP | 1.46e-18 | -2.56e-01 | -0.0452 |
8886 | DDX18 | A014-C-008 | Human | Colorectum | FAP | 2.05e-06 | -2.81e-02 | -0.191 |
8886 | DDX18 | A018-E-020 | Human | Colorectum | FAP | 1.61e-11 | -2.62e-01 | -0.2034 |
8886 | DDX18 | F034 | Human | Colorectum | FAP | 1.30e-08 | 4.18e-02 | -0.0665 |
8886 | DDX18 | F072B | Human | Colorectum | FAP | 4.11e-06 | -1.47e-01 | 0.257 |
8886 | DDX18 | CRC-1-8810 | Human | Colorectum | CRC | 4.10e-02 | 1.68e-01 | 0.6257 |
8886 | DDX18 | CRC-3-11773 | Human | Colorectum | CRC | 2.20e-07 | 3.21e-01 | 0.2564 |
8886 | DDX18 | AEH-subject1 | Human | Endometrium | AEH | 5.89e-09 | -2.67e-01 | -0.3059 |
8886 | DDX18 | AEH-subject2 | Human | Endometrium | AEH | 5.26e-11 | -3.02e-01 | -0.2525 |
8886 | DDX18 | AEH-subject3 | Human | Endometrium | AEH | 6.05e-11 | -2.43e-01 | -0.2576 |
8886 | DDX18 | AEH-subject4 | Human | Endometrium | AEH | 9.41e-19 | -4.96e-01 | -0.2657 |
8886 | DDX18 | AEH-subject5 | Human | Endometrium | AEH | 3.14e-10 | -2.84e-01 | -0.2953 |
8886 | DDX18 | EEC-subject1 | Human | Endometrium | EEC | 2.06e-18 | -4.07e-01 | -0.2682 |
8886 | DDX18 | EEC-subject2 | Human | Endometrium | EEC | 6.35e-08 | -1.16e-01 | -0.2607 |
8886 | DDX18 | EEC-subject3 | Human | Endometrium | EEC | 3.79e-31 | -2.96e-01 | -0.2525 |
8886 | DDX18 | EEC-subject4 | Human | Endometrium | EEC | 1.81e-17 | -4.04e-01 | -0.2571 |
8886 | DDX18 | EEC-subject5 | Human | Endometrium | EEC | 3.14e-11 | -3.60e-01 | -0.249 |
8886 | DDX18 | GSM5276934 | Human | Endometrium | EEC | 8.81e-08 | -1.72e-02 | -0.0913 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004227310 | Cervix | CC | ribosomal large subunit biogenesis | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:00323556 | Cervix | CC | response to estradiol | 34/2311 | 141/18723 | 8.19e-05 | 1.11e-03 | 34 |
GO:00160727 | Cervix | CC | rRNA metabolic process | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00422732 | Colorectum | MSS | ribosomal large subunit biogenesis | 28/3467 | 72/18723 | 4.16e-05 | 7.83e-04 | 28 |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:0000470 | Colorectum | MSS | maturation of LSU-rRNA | 12/3467 | 28/18723 | 2.53e-03 | 2.02e-02 | 12 |
GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00226134 | Colorectum | FAP | ribonucleoprotein complex biogenesis | 91/2622 | 463/18723 | 4.28e-04 | 5.12e-03 | 91 |
GO:00226135 | Colorectum | CRC | ribonucleoprotein complex biogenesis | 76/2078 | 463/18723 | 3.04e-04 | 4.78e-03 | 76 |
GO:0032355 | Colorectum | CRC | response to estradiol | 27/2078 | 141/18723 | 3.24e-03 | 2.81e-02 | 27 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:004227316 | Endometrium | AEH | ribosomal large subunit biogenesis | 30/2100 | 72/18723 | 3.69e-11 | 5.03e-09 | 30 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:00323557 | Endometrium | AEH | response to estradiol | 34/2100 | 141/18723 | 1.13e-05 | 2.53e-04 | 34 |
GO:00063648 | Endometrium | AEH | rRNA processing | 47/2100 | 225/18723 | 1.78e-05 | 3.65e-04 | 47 |
GO:00004704 | Endometrium | AEH | maturation of LSU-rRNA | 12/2100 | 28/18723 | 2.08e-05 | 4.13e-04 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX18 | SNV | Missense_Mutation | novel | c.135N>C | p.Glu45Asp | p.E45D | Q9NVP1 | protein_coding | tolerated_low_confidence(0.29) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX18 | SNV | Missense_Mutation | c.1106N>A | p.Arg369Gln | p.R369Q | Q9NVP1 | protein_coding | tolerated(0.51) | benign(0.01) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX18 | SNV | Missense_Mutation | c.1117G>C | p.Asp373His | p.D373H | Q9NVP1 | protein_coding | deleterious(0) | benign(0.264) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
DDX18 | SNV | Missense_Mutation | c.382N>A | p.Ala128Thr | p.A128T | Q9NVP1 | protein_coding | tolerated(0.21) | benign(0) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
DDX18 | SNV | Missense_Mutation | rs374687356 | c.1616G>A | p.Arg539His | p.R539H | Q9NVP1 | protein_coding | tolerated(0.06) | benign(0.015) | TCGA-LL-A6FQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DDX18 | SNV | Missense_Mutation | c.1117G>T | p.Asp373Tyr | p.D373Y | Q9NVP1 | protein_coding | deleterious(0) | benign(0.115) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DDX18 | SNV | Missense_Mutation | c.1460G>A | p.Arg487Lys | p.R487K | Q9NVP1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
DDX18 | SNV | Missense_Mutation | c.1696N>C | p.Glu566Gln | p.E566Q | Q9NVP1 | protein_coding | deleterious(0.01) | benign(0.098) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DDX18 | SNV | Missense_Mutation | c.1012N>C | p.Ile338Leu | p.I338L | Q9NVP1 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DDX18 | SNV | Missense_Mutation | c.769N>T | p.Leu257Phe | p.L257F | Q9NVP1 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-AA-3489-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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