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Gene: DDB2 |
Gene summary for DDB2 |
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Gene information | Species | Human | Gene symbol | DDB2 | Gene ID | 1643 |
Gene name | damage specific DNA binding protein 2 | |
Gene Alias | DDBB | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q92466 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1643 | DDB2 | P11T-E | Human | Esophagus | ESCC | 9.58e-08 | 3.43e-01 | 0.1426 |
1643 | DDB2 | P12T-E | Human | Esophagus | ESCC | 1.71e-16 | 3.81e-01 | 0.1122 |
1643 | DDB2 | P15T-E | Human | Esophagus | ESCC | 1.03e-20 | 2.68e-01 | 0.1149 |
1643 | DDB2 | P16T-E | Human | Esophagus | ESCC | 2.24e-09 | 1.80e-01 | 0.1153 |
1643 | DDB2 | P17T-E | Human | Esophagus | ESCC | 1.69e-04 | 3.38e-01 | 0.1278 |
1643 | DDB2 | P20T-E | Human | Esophagus | ESCC | 4.54e-25 | 5.77e-01 | 0.1124 |
1643 | DDB2 | P21T-E | Human | Esophagus | ESCC | 8.15e-39 | 7.48e-01 | 0.1617 |
1643 | DDB2 | P22T-E | Human | Esophagus | ESCC | 6.05e-23 | 4.55e-01 | 0.1236 |
1643 | DDB2 | P23T-E | Human | Esophagus | ESCC | 4.92e-15 | 4.91e-01 | 0.108 |
1643 | DDB2 | P24T-E | Human | Esophagus | ESCC | 1.40e-06 | 1.69e-01 | 0.1287 |
1643 | DDB2 | P26T-E | Human | Esophagus | ESCC | 1.05e-41 | 7.48e-01 | 0.1276 |
1643 | DDB2 | P27T-E | Human | Esophagus | ESCC | 8.68e-24 | 4.54e-01 | 0.1055 |
1643 | DDB2 | P28T-E | Human | Esophagus | ESCC | 8.37e-16 | 4.05e-01 | 0.1149 |
1643 | DDB2 | P30T-E | Human | Esophagus | ESCC | 2.15e-13 | 6.20e-01 | 0.137 |
1643 | DDB2 | P31T-E | Human | Esophagus | ESCC | 3.78e-29 | 4.97e-01 | 0.1251 |
1643 | DDB2 | P32T-E | Human | Esophagus | ESCC | 1.45e-19 | 5.04e-01 | 0.1666 |
1643 | DDB2 | P37T-E | Human | Esophagus | ESCC | 6.09e-11 | 2.91e-01 | 0.1371 |
1643 | DDB2 | P39T-E | Human | Esophagus | ESCC | 3.10e-10 | 1.06e-01 | 0.0894 |
1643 | DDB2 | P40T-E | Human | Esophagus | ESCC | 1.18e-13 | 3.27e-01 | 0.109 |
1643 | DDB2 | P42T-E | Human | Esophagus | ESCC | 3.10e-09 | 3.39e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0051865 | Colorectum | AD | protein autoubiquitination | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:0033522 | Colorectum | AD | histone H2A ubiquitination | 12/3918 | 26/18723 | 3.47e-03 | 2.51e-02 | 12 |
GO:0006513 | Colorectum | AD | protein monoubiquitination | 23/3918 | 67/18723 | 7.55e-03 | 4.58e-02 | 23 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00518651 | Colorectum | MSS | protein autoubiquitination | 25/3467 | 73/18723 | 1.00e-03 | 1.00e-02 | 25 |
GO:00335221 | Colorectum | MSS | histone H2A ubiquitination | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
GO:00065131 | Colorectum | MSS | protein monoubiquitination | 21/3467 | 67/18723 | 7.90e-03 | 4.84e-02 | 21 |
GO:0016574 | Colorectum | MSS | histone ubiquitination | 16/3467 | 47/18723 | 8.22e-03 | 4.99e-02 | 16 |
GO:00002093 | Colorectum | FAP | protein polyubiquitination | 59/2622 | 236/18723 | 4.53e-06 | 1.52e-04 | 59 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00518652 | Colorectum | FAP | protein autoubiquitination | 22/2622 | 73/18723 | 2.88e-04 | 3.77e-03 | 22 |
GO:00335222 | Colorectum | FAP | histone H2A ubiquitination | 10/2622 | 26/18723 | 1.77e-03 | 1.53e-02 | 10 |
GO:00165741 | Colorectum | FAP | histone ubiquitination | 14/2622 | 47/18723 | 3.95e-03 | 2.75e-02 | 14 |
GO:00065132 | Colorectum | FAP | protein monoubiquitination | 18/2622 | 67/18723 | 4.08e-03 | 2.81e-02 | 18 |
GO:0071214 | Colorectum | FAP | cellular response to abiotic stimulus | 63/2622 | 331/18723 | 6.38e-03 | 3.99e-02 | 63 |
GO:0104004 | Colorectum | FAP | cellular response to environmental stimulus | 63/2622 | 331/18723 | 6.38e-03 | 3.99e-02 | 63 |
GO:000020916 | Esophagus | HGIN | protein polyubiquitination | 58/2587 | 236/18723 | 6.29e-06 | 1.97e-04 | 58 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa05213 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa05216 | Colorectum | AD | Thyroid cancer | 21/2092 | 37/8465 | 3.05e-05 | 2.76e-04 | 1.76e-04 | 21 |
hsa05210 | Colorectum | AD | Colorectal cancer | 35/2092 | 86/8465 | 7.54e-04 | 5.49e-03 | 3.50e-03 | 35 |
hsa05220 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa05225 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa05212 | Colorectum | AD | Pancreatic cancer | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa052131 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa052161 | Colorectum | AD | Thyroid cancer | 21/2092 | 37/8465 | 3.05e-05 | 2.76e-04 | 1.76e-04 | 21 |
hsa052101 | Colorectum | AD | Colorectal cancer | 35/2092 | 86/8465 | 7.54e-04 | 5.49e-03 | 3.50e-03 | 35 |
hsa052201 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa052251 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa052121 | Colorectum | AD | Pancreatic cancer | 29/2092 | 76/8465 | 6.25e-03 | 2.68e-02 | 1.71e-02 | 29 |
hsa052162 | Colorectum | MSS | Thyroid cancer | 21/1875 | 37/8465 | 4.98e-06 | 6.00e-05 | 3.68e-05 | 21 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa052202 | Colorectum | MSS | Chronic myeloid leukemia | 29/1875 | 76/8465 | 1.10e-03 | 6.27e-03 | 3.84e-03 | 29 |
hsa05169 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa052122 | Colorectum | MSS | Pancreatic cancer | 26/1875 | 76/8465 | 1.04e-02 | 3.69e-02 | 2.26e-02 | 26 |
hsa05222 | Colorectum | MSS | Small cell lung cancer | 30/1875 | 92/8465 | 1.31e-02 | 4.30e-02 | 2.64e-02 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDB2 | SNV | Missense_Mutation | c.716N>A | p.Arg239Lys | p.R239K | Q92466 | protein_coding | tolerated(0.99) | benign(0.049) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
DDB2 | deletion | Frame_Shift_Del | novel | c.1034delA | p.His345LeufsTer25 | p.H345Lfs*25 | Q92466 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
DDB2 | SNV | Missense_Mutation | c.807N>G | p.Ile269Met | p.I269M | Q92466 | protein_coding | tolerated(0.09) | possibly_damaging(0.732) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DDB2 | SNV | Missense_Mutation | novel | c.145N>C | p.Asp49His | p.D49H | Q92466 | protein_coding | deleterious(0.01) | possibly_damaging(0.674) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
DDB2 | SNV | Missense_Mutation | rs375649516 | c.1126N>A | p.Asp376Asn | p.D376N | Q92466 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDB2 | SNV | Missense_Mutation | novel | c.1200C>A | p.Phe400Leu | p.F400L | Q92466 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
DDB2 | SNV | Missense_Mutation | novel | c.1019N>C | p.Ile340Thr | p.I340T | Q92466 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DDB2 | SNV | Missense_Mutation | novel | c.1028N>T | p.Ala343Val | p.A343V | Q92466 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DDB2 | SNV | Missense_Mutation | novel | c.1276N>T | p.Arg426Trp | p.R426W | Q92466 | protein_coding | deleterious(0) | benign(0) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
DDB2 | SNV | Missense_Mutation | novel | c.863N>T | p.Arg288Met | p.R288M | Q92466 | protein_coding | deleterious(0.04) | benign(0.251) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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