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Gene: DCAF6 |
Gene summary for DCAF6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DCAF6 | Gene ID | 55827 |
| Gene name | DDB1 and CUL4 associated factor 6 | |
| Gene Alias | 1200006M05Rik | |
| Cytomap | 1q24.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q58WW2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55827 | DCAF6 | A002-C-010 | Human | Colorectum | FAP | 4.84e-03 | -2.11e-01 | 0.242 |
| 55827 | DCAF6 | A001-C-207 | Human | Colorectum | FAP | 2.00e-07 | -4.55e-01 | 0.1278 |
| 55827 | DCAF6 | A015-C-203 | Human | Colorectum | FAP | 3.67e-28 | -4.81e-01 | -0.1294 |
| 55827 | DCAF6 | A015-C-204 | Human | Colorectum | FAP | 9.82e-12 | -5.25e-01 | -0.0228 |
| 55827 | DCAF6 | A014-C-040 | Human | Colorectum | FAP | 4.02e-04 | -3.64e-01 | -0.1184 |
| 55827 | DCAF6 | A002-C-201 | Human | Colorectum | FAP | 5.16e-25 | -6.17e-01 | 0.0324 |
| 55827 | DCAF6 | A002-C-203 | Human | Colorectum | FAP | 5.57e-06 | -3.77e-01 | 0.2786 |
| 55827 | DCAF6 | A001-C-119 | Human | Colorectum | FAP | 1.81e-05 | -3.34e-01 | -0.1557 |
| 55827 | DCAF6 | A001-C-108 | Human | Colorectum | FAP | 9.88e-19 | -4.96e-01 | -0.0272 |
| 55827 | DCAF6 | A002-C-205 | Human | Colorectum | FAP | 7.79e-30 | -5.63e-01 | -0.1236 |
| 55827 | DCAF6 | A001-C-104 | Human | Colorectum | FAP | 1.11e-04 | -3.53e-01 | 0.0184 |
| 55827 | DCAF6 | A015-C-005 | Human | Colorectum | FAP | 2.74e-03 | -3.09e-01 | -0.0336 |
| 55827 | DCAF6 | A015-C-006 | Human | Colorectum | FAP | 9.38e-22 | -5.82e-01 | -0.0994 |
| 55827 | DCAF6 | A015-C-106 | Human | Colorectum | FAP | 2.67e-14 | -4.36e-01 | -0.0511 |
| 55827 | DCAF6 | A002-C-114 | Human | Colorectum | FAP | 1.51e-25 | -6.33e-01 | -0.1561 |
| 55827 | DCAF6 | A015-C-104 | Human | Colorectum | FAP | 3.55e-35 | -5.28e-01 | -0.1899 |
| 55827 | DCAF6 | A001-C-014 | Human | Colorectum | FAP | 1.56e-19 | -4.72e-01 | 0.0135 |
| 55827 | DCAF6 | A002-C-016 | Human | Colorectum | FAP | 8.82e-32 | -5.26e-01 | 0.0521 |
| 55827 | DCAF6 | A015-C-002 | Human | Colorectum | FAP | 8.23e-17 | -5.06e-01 | -0.0763 |
| 55827 | DCAF6 | A001-C-007 | Human | Colorectum | CRC | 1.05e-06 | -6.49e-01 | 0.1899 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DCAF6 | SNV | Missense_Mutation | c.1189N>G | p.Thr397Ala | p.T397A | Q58WW2 | protein_coding | tolerated(0.17) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DCAF6 | SNV | Missense_Mutation | novel | c.2701G>A | p.Glu901Lys | p.E901K | Q58WW2 | protein_coding | tolerated(0.09) | benign(0.266) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| DCAF6 | SNV | Missense_Mutation | rs765173203 | c.584C>T | p.Thr195Met | p.T195M | Q58WW2 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| DCAF6 | SNV | Missense_Mutation | c.1258N>G | p.Gln420Glu | p.Q420E | Q58WW2 | protein_coding | tolerated_low_confidence(0.13) | benign(0.074) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| DCAF6 | SNV | Missense_Mutation | c.190G>A | p.Glu64Lys | p.E64K | Q58WW2 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-D8-A1JH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | nolvadex | SD | |
| DCAF6 | SNV | Missense_Mutation | c.2393C>T | p.Pro798Leu | p.P798L | Q58WW2 | protein_coding | tolerated(0.15) | possibly_damaging(0.478) | TCGA-E2-A1L6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| DCAF6 | insertion | Nonsense_Mutation | novel | c.2762_2763insAACTCTACTTTCTTA | p.Met921delinsIleThrLeuLeuSerTer | p.M921delinsITLLS* | Q58WW2 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| DCAF6 | insertion | In_Frame_Ins | novel | c.2763_2764insCAAAAGAGTTTTTTCTTTATTGGTTTC | p.Met921_Leu922insGlnLysSerPhePhePheIleGlyPhe | p.M921_L922insQKSFFFIGF | Q58WW2 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| DCAF6 | SNV | Missense_Mutation | rs745578537 | c.1244N>T | p.Ser415Phe | p.S415F | Q58WW2 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.837) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
| DCAF6 | SNV | Missense_Mutation | c.1258C>G | p.Gln420Glu | p.Q420E | Q58WW2 | protein_coding | tolerated_low_confidence(0.13) | benign(0.074) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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