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Gene: CYTOR |
Gene summary for CYTOR |
Gene summary. |
Gene information | Species | Human | Gene symbol | CYTOR | Gene ID | 112597 |
Gene name | cytoskeleton regulator RNA | |
Gene Alias | C2orf59 | |
Cytomap | 2p11.2 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112597 | CYTOR | DCIS2 | Human | Breast | DCIS | 5.23e-68 | 3.32e-01 | 0.0085 |
112597 | CYTOR | sample1 | Human | Cervix | CC | 9.09e-25 | 6.87e-01 | 0.0959 |
112597 | CYTOR | sample3 | Human | Cervix | CC | 1.02e-16 | 2.73e-01 | 0.1387 |
112597 | CYTOR | H2 | Human | Cervix | HSIL_HPV | 4.50e-17 | 3.33e-01 | 0.0632 |
112597 | CYTOR | T1 | Human | Cervix | CC | 9.52e-38 | 6.37e-01 | 0.0918 |
112597 | CYTOR | T2 | Human | Cervix | CC | 1.32e-11 | 4.13e-01 | 0.0709 |
112597 | CYTOR | T3 | Human | Cervix | CC | 5.24e-16 | 2.51e-01 | 0.1389 |
112597 | CYTOR | AEH-subject1 | Human | Endometrium | AEH | 1.88e-08 | 1.79e-01 | -0.3059 |
112597 | CYTOR | AEH-subject2 | Human | Endometrium | AEH | 1.50e-09 | 2.54e-01 | -0.2525 |
112597 | CYTOR | AEH-subject3 | Human | Endometrium | AEH | 3.89e-10 | 2.74e-01 | -0.2576 |
112597 | CYTOR | AEH-subject4 | Human | Endometrium | AEH | 3.58e-13 | 3.75e-01 | -0.2657 |
112597 | CYTOR | AEH-subject5 | Human | Endometrium | AEH | 4.35e-17 | 3.33e-01 | -0.2953 |
112597 | CYTOR | EEC-subject1 | Human | Endometrium | EEC | 4.01e-09 | 2.98e-01 | -0.2682 |
112597 | CYTOR | EEC-subject2 | Human | Endometrium | EEC | 3.71e-04 | 1.69e-01 | -0.2607 |
112597 | CYTOR | EEC-subject3 | Human | Endometrium | EEC | 2.90e-14 | 4.47e-01 | -0.2525 |
112597 | CYTOR | EEC-subject4 | Human | Endometrium | EEC | 1.82e-05 | 1.68e-01 | -0.2571 |
112597 | CYTOR | EEC-subject5 | Human | Endometrium | EEC | 8.49e-10 | 2.52e-01 | -0.249 |
112597 | CYTOR | GSM5276934 | Human | Endometrium | EEC | 5.63e-73 | 1.13e+00 | -0.0913 |
112597 | CYTOR | GSM5276935 | Human | Endometrium | EEC | 5.07e-16 | 3.20e-01 | -0.123 |
112597 | CYTOR | GSM5276937 | Human | Endometrium | EEC | 1.64e-91 | 1.45e+00 | -0.0897 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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