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Gene: CYB561 |
Gene summary for CYB561 |
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Gene information | Species | Human | Gene symbol | CYB561 | Gene ID | 1534 |
Gene name | cytochrome b561 | |
Gene Alias | CYB561A1 | |
Cytomap | 17q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | B3KTA1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1534 | CYB561 | LZE24T | Human | Esophagus | ESCC | 2.12e-16 | 6.41e-01 | 0.0596 |
1534 | CYB561 | P1T-E | Human | Esophagus | ESCC | 4.33e-18 | 1.19e+00 | 0.0875 |
1534 | CYB561 | P2T-E | Human | Esophagus | ESCC | 2.19e-62 | 1.05e+00 | 0.1177 |
1534 | CYB561 | P4T-E | Human | Esophagus | ESCC | 8.97e-14 | 4.58e-01 | 0.1323 |
1534 | CYB561 | P5T-E | Human | Esophagus | ESCC | 7.07e-11 | -1.37e-02 | 0.1327 |
1534 | CYB561 | P8T-E | Human | Esophagus | ESCC | 8.85e-45 | 7.52e-01 | 0.0889 |
1534 | CYB561 | P9T-E | Human | Esophagus | ESCC | 2.34e-08 | 2.49e-01 | 0.1131 |
1534 | CYB561 | P10T-E | Human | Esophagus | ESCC | 6.54e-16 | 2.67e-01 | 0.116 |
1534 | CYB561 | P11T-E | Human | Esophagus | ESCC | 4.01e-16 | 9.28e-01 | 0.1426 |
1534 | CYB561 | P12T-E | Human | Esophagus | ESCC | 1.15e-27 | 4.71e-01 | 0.1122 |
1534 | CYB561 | P15T-E | Human | Esophagus | ESCC | 4.32e-22 | 6.43e-01 | 0.1149 |
1534 | CYB561 | P16T-E | Human | Esophagus | ESCC | 1.00e-41 | 8.63e-01 | 0.1153 |
1534 | CYB561 | P19T-E | Human | Esophagus | ESCC | 1.49e-03 | 4.51e-01 | 0.1662 |
1534 | CYB561 | P20T-E | Human | Esophagus | ESCC | 8.70e-15 | 3.46e-01 | 0.1124 |
1534 | CYB561 | P21T-E | Human | Esophagus | ESCC | 3.61e-57 | 1.12e+00 | 0.1617 |
1534 | CYB561 | P22T-E | Human | Esophagus | ESCC | 5.33e-30 | 5.11e-01 | 0.1236 |
1534 | CYB561 | P23T-E | Human | Esophagus | ESCC | 8.65e-54 | 1.68e+00 | 0.108 |
1534 | CYB561 | P24T-E | Human | Esophagus | ESCC | 4.23e-23 | 6.55e-01 | 0.1287 |
1534 | CYB561 | P26T-E | Human | Esophagus | ESCC | 3.66e-14 | 3.91e-01 | 0.1276 |
1534 | CYB561 | P27T-E | Human | Esophagus | ESCC | 8.90e-21 | 4.16e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0022900 | Colorectum | AD | electron transport chain | 89/3918 | 175/18723 | 1.42e-18 | 8.91e-16 | 89 |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0046916 | Colorectum | AD | cellular transition metal ion homeostasis | 43/3918 | 115/18723 | 3.62e-05 | 6.56e-04 | 43 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0006879 | Colorectum | AD | cellular iron ion homeostasis | 25/3918 | 67/18723 | 1.51e-03 | 1.27e-02 | 25 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00229001 | Colorectum | SER | electron transport chain | 77/2897 | 175/18723 | 1.77e-19 | 1.36e-16 | 77 |
GO:00550761 | Colorectum | SER | transition metal ion homeostasis | 41/2897 | 138/18723 | 1.66e-05 | 5.05e-04 | 41 |
GO:00469161 | Colorectum | SER | cellular transition metal ion homeostasis | 33/2897 | 115/18723 | 2.20e-04 | 3.89e-03 | 33 |
GO:00550721 | Colorectum | SER | iron ion homeostasis | 24/2897 | 85/18723 | 1.91e-03 | 1.93e-02 | 24 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00229002 | Colorectum | MSS | electron transport chain | 83/3467 | 175/18723 | 2.06e-18 | 1.17e-15 | 83 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00550722 | Colorectum | MSS | iron ion homeostasis | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
GO:00469162 | Colorectum | MSS | cellular transition metal ion homeostasis | 35/3467 | 115/18723 | 1.33e-03 | 1.26e-02 | 35 |
GO:00068791 | Colorectum | MSS | cellular iron ion homeostasis | 22/3467 | 67/18723 | 3.57e-03 | 2.64e-02 | 22 |
GO:00229003 | Colorectum | MSI-H | electron transport chain | 52/1319 | 175/18723 | 1.13e-19 | 5.21e-17 | 52 |
GO:00060913 | Colorectum | MSI-H | generation of precursor metabolites and energy | 93/1319 | 490/18723 | 7.35e-19 | 3.14e-16 | 93 |
GO:00550763 | Colorectum | MSI-H | transition metal ion homeostasis | 20/1319 | 138/18723 | 1.62e-03 | 2.40e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYB561 | SNV | Missense_Mutation | c.649N>A | p.Cys217Ser | p.C217S | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CYB561 | deletion | Frame_Shift_Del | novel | c.731delN | p.Met244ArgfsTer6 | p.M244Rfs*6 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
CYB561 | SNV | Missense_Mutation | novel | c.502N>G | p.Ile168Val | p.I168V | protein_coding | tolerated(1) | benign(0) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CYB561 | SNV | Missense_Mutation | novel | c.604N>C | p.Glu202Gln | p.E202Q | protein_coding | tolerated(0.58) | benign(0.014) | TCGA-ZJ-AAXI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYB561 | SNV | Missense_Mutation | rs374915589 | c.662N>T | p.Ala221Val | p.A221V | protein_coding | tolerated(1) | benign(0) | TCGA-A6-5660-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
CYB561 | SNV | Missense_Mutation | rs376683537 | c.484N>T | p.Arg162Cys | p.R162C | protein_coding | tolerated(0.18) | benign(0.021) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYB561 | SNV | Missense_Mutation | c.407N>A | p.Phe136Tyr | p.F136Y | protein_coding | deleterious(0.01) | benign(0.021) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CYB561 | SNV | Missense_Mutation | c.364N>T | p.Ala122Ser | p.A122S | protein_coding | tolerated(0.13) | possibly_damaging(0.533) | TCGA-D5-6529-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatinum+ | SD | ||
CYB561 | SNV | Missense_Mutation | c.175N>A | p.Ala59Thr | p.A59T | protein_coding | tolerated(0.26) | benign(0.041) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CYB561 | SNV | Missense_Mutation | novel | c.665N>C | p.Val222Ala | p.V222A | protein_coding | deleterious(0.01) | possibly_damaging(0.856) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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