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Gene: CTNNBIP1 |
Gene summary for CTNNBIP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CTNNBIP1 | Gene ID | 56998 |
| Gene name | catenin beta interacting protein 1 | |
| Gene Alias | ICAT | |
| Cytomap | 1p36.22 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R4D7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 56998 | CTNNBIP1 | P21T-E | Human | Esophagus | ESCC | 4.50e-78 | 2.06e+00 | 0.1617 |
| 56998 | CTNNBIP1 | P22T-E | Human | Esophagus | ESCC | 9.82e-49 | 9.56e-01 | 0.1236 |
| 56998 | CTNNBIP1 | P23T-E | Human | Esophagus | ESCC | 1.16e-40 | 1.14e+00 | 0.108 |
| 56998 | CTNNBIP1 | P24T-E | Human | Esophagus | ESCC | 1.49e-32 | 8.21e-01 | 0.1287 |
| 56998 | CTNNBIP1 | P26T-E | Human | Esophagus | ESCC | 1.54e-34 | 7.19e-01 | 0.1276 |
| 56998 | CTNNBIP1 | P27T-E | Human | Esophagus | ESCC | 2.15e-49 | 1.08e+00 | 0.1055 |
| 56998 | CTNNBIP1 | P28T-E | Human | Esophagus | ESCC | 1.80e-52 | 1.26e+00 | 0.1149 |
| 56998 | CTNNBIP1 | P30T-E | Human | Esophagus | ESCC | 3.36e-38 | 1.39e+00 | 0.137 |
| 56998 | CTNNBIP1 | P31T-E | Human | Esophagus | ESCC | 4.56e-51 | 1.10e+00 | 0.1251 |
| 56998 | CTNNBIP1 | P32T-E | Human | Esophagus | ESCC | 6.04e-39 | 1.10e+00 | 0.1666 |
| 56998 | CTNNBIP1 | P36T-E | Human | Esophagus | ESCC | 1.60e-17 | 6.94e-01 | 0.1187 |
| 56998 | CTNNBIP1 | P37T-E | Human | Esophagus | ESCC | 3.04e-38 | 1.11e+00 | 0.1371 |
| 56998 | CTNNBIP1 | P38T-E | Human | Esophagus | ESCC | 2.65e-22 | 1.05e+00 | 0.127 |
| 56998 | CTNNBIP1 | P39T-E | Human | Esophagus | ESCC | 7.47e-27 | 6.92e-01 | 0.0894 |
| 56998 | CTNNBIP1 | P40T-E | Human | Esophagus | ESCC | 1.35e-34 | 1.33e+00 | 0.109 |
| 56998 | CTNNBIP1 | P42T-E | Human | Esophagus | ESCC | 1.43e-29 | 8.89e-01 | 0.1175 |
| 56998 | CTNNBIP1 | P44T-E | Human | Esophagus | ESCC | 1.96e-14 | 6.00e-01 | 0.1096 |
| 56998 | CTNNBIP1 | P47T-E | Human | Esophagus | ESCC | 5.07e-24 | 5.11e-01 | 0.1067 |
| 56998 | CTNNBIP1 | P48T-E | Human | Esophagus | ESCC | 4.10e-29 | 7.92e-01 | 0.0959 |
| 56998 | CTNNBIP1 | P49T-E | Human | Esophagus | ESCC | 2.96e-24 | 2.76e+00 | 0.1768 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
| GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
| GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
| GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
| GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
| GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
| GO:0051101111 | Esophagus | ESCC | regulation of DNA binding | 84/8552 | 118/18723 | 1.64e-08 | 3.21e-07 | 84 |
| GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
| GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
| GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
| GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
| GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
| GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
| GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
| GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
| GO:003209116 | Esophagus | ESCC | negative regulation of protein binding | 65/8552 | 94/18723 | 3.46e-06 | 3.82e-05 | 65 |
| GO:006056210 | Esophagus | ESCC | epithelial tube morphogenesis | 187/8552 | 325/18723 | 9.95e-06 | 9.44e-05 | 187 |
| GO:0031333110 | Esophagus | ESCC | negative regulation of protein-containing complex assembly | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
| GO:00433924 | Esophagus | ESCC | negative regulation of DNA binding | 37/8552 | 52/18723 | 1.75e-04 | 1.14e-03 | 37 |
| GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CTNNBIP1 | SNV | Missense_Mutation | novel | c.35N>G | p.Glu12Gly | p.E12G | Q9NSA3 | protein_coding | deleterious(0.01) | benign(0.078) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| CTNNBIP1 | SNV | Missense_Mutation | novel | c.191N>T | p.Ala64Val | p.A64V | Q9NSA3 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
| CTNNBIP1 | SNV | Missense_Mutation | novel | c.199N>A | p.Val67Met | p.V67M | Q9NSA3 | protein_coding | tolerated(0.09) | benign(0.115) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CTNNBIP1 | SNV | Missense_Mutation | c.203N>C | p.Val68Ala | p.V68A | Q9NSA3 | protein_coding | deleterious(0) | benign(0.018) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CTNNBIP1 | SNV | Missense_Mutation | novel | c.241N>G | p.Gln81Glu | p.Q81E | Q9NSA3 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.523) | TCGA-VQ-A8DZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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