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Gene: CSTF1 |
Gene summary for CSTF1 |
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Gene information | Species | Human | Gene symbol | CSTF1 | Gene ID | 1477 |
Gene name | cleavage stimulation factor subunit 1 | |
Gene Alias | CstF-50 | |
Cytomap | 20q13.2-q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q05048 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1477 | CSTF1 | P19T-E | Human | Esophagus | ESCC | 6.03e-08 | 3.85e-01 | 0.1662 |
1477 | CSTF1 | P20T-E | Human | Esophagus | ESCC | 7.75e-28 | 5.45e-01 | 0.1124 |
1477 | CSTF1 | P21T-E | Human | Esophagus | ESCC | 7.42e-16 | 3.19e-01 | 0.1617 |
1477 | CSTF1 | P22T-E | Human | Esophagus | ESCC | 1.16e-19 | 2.97e-01 | 0.1236 |
1477 | CSTF1 | P23T-E | Human | Esophagus | ESCC | 1.15e-22 | 4.53e-01 | 0.108 |
1477 | CSTF1 | P24T-E | Human | Esophagus | ESCC | 1.12e-13 | 2.62e-01 | 0.1287 |
1477 | CSTF1 | P26T-E | Human | Esophagus | ESCC | 9.02e-31 | 5.04e-01 | 0.1276 |
1477 | CSTF1 | P27T-E | Human | Esophagus | ESCC | 3.05e-11 | 1.55e-01 | 0.1055 |
1477 | CSTF1 | P28T-E | Human | Esophagus | ESCC | 2.67e-10 | 1.96e-01 | 0.1149 |
1477 | CSTF1 | P30T-E | Human | Esophagus | ESCC | 5.97e-13 | 3.77e-01 | 0.137 |
1477 | CSTF1 | P31T-E | Human | Esophagus | ESCC | 7.55e-29 | 3.62e-01 | 0.1251 |
1477 | CSTF1 | P32T-E | Human | Esophagus | ESCC | 2.12e-17 | 3.02e-01 | 0.1666 |
1477 | CSTF1 | P36T-E | Human | Esophagus | ESCC | 1.02e-12 | 3.74e-01 | 0.1187 |
1477 | CSTF1 | P37T-E | Human | Esophagus | ESCC | 1.23e-10 | 1.64e-01 | 0.1371 |
1477 | CSTF1 | P39T-E | Human | Esophagus | ESCC | 9.76e-12 | 1.63e-01 | 0.0894 |
1477 | CSTF1 | P40T-E | Human | Esophagus | ESCC | 3.19e-04 | 1.13e-01 | 0.109 |
1477 | CSTF1 | P42T-E | Human | Esophagus | ESCC | 1.04e-16 | 3.15e-01 | 0.1175 |
1477 | CSTF1 | P44T-E | Human | Esophagus | ESCC | 2.16e-06 | 1.41e-01 | 0.1096 |
1477 | CSTF1 | P47T-E | Human | Esophagus | ESCC | 6.92e-11 | 2.19e-01 | 0.1067 |
1477 | CSTF1 | P48T-E | Human | Esophagus | ESCC | 7.44e-09 | 1.58e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003112412 | Esophagus | ESCC | mRNA 3'-end processing | 47/8552 | 62/18723 | 1.29e-06 | 1.58e-05 | 47 |
GO:00311233 | Esophagus | ESCC | RNA 3'-end processing | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:00311241 | Liver | HCC | mRNA 3'-end processing | 50/7958 | 62/18723 | 8.44e-10 | 2.60e-08 | 50 |
GO:00311231 | Liver | HCC | RNA 3'-end processing | 81/7958 | 116/18723 | 2.27e-09 | 6.32e-08 | 81 |
GO:00311242 | Oral cavity | OSCC | mRNA 3'-end processing | 49/7305 | 62/18723 | 1.40e-10 | 4.14e-09 | 49 |
GO:00311232 | Oral cavity | OSCC | RNA 3'-end processing | 75/7305 | 116/18723 | 1.93e-08 | 3.79e-07 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0301521 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa0301531 | Liver | HCC | mRNA surveillance pathway | 66/4020 | 97/8465 | 3.16e-05 | 1.88e-04 | 1.04e-04 | 66 |
hsa030158 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
hsa0301513 | Oral cavity | OSCC | mRNA surveillance pathway | 75/3704 | 97/8465 | 1.30e-11 | 2.01e-10 | 1.02e-10 | 75 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSTF1 | SNV | Missense_Mutation | c.24N>C | p.Leu8Phe | p.L8F | Q05048 | protein_coding | deleterious(0.01) | benign(0) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CSTF1 | SNV | Missense_Mutation | c.1209N>G | p.Ile403Met | p.I403M | Q05048 | protein_coding | tolerated(0.05) | benign(0.406) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
CSTF1 | SNV | Missense_Mutation | novel | c.613N>T | p.Pro205Ser | p.P205S | Q05048 | protein_coding | tolerated(0.53) | benign(0.043) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CSTF1 | SNV | Missense_Mutation | c.1241N>T | p.Thr414Met | p.T414M | Q05048 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CSTF1 | SNV | Missense_Mutation | c.1073A>G | p.Gln358Arg | p.Q358R | Q05048 | protein_coding | tolerated(0.05) | benign(0.043) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD | |
CSTF1 | SNV | Missense_Mutation | rs140246355 | c.832G>A | p.Val278Ile | p.V278I | Q05048 | protein_coding | tolerated(0.08) | benign(0.317) | TCGA-AA-3696-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CSTF1 | SNV | Missense_Mutation | c.31N>T | p.Arg11Cys | p.R11C | Q05048 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CSTF1 | SNV | Missense_Mutation | c.31N>T | p.Arg11Cys | p.R11C | Q05048 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSTF1 | SNV | Missense_Mutation | novel | c.874N>A | p.Val292Ile | p.V292I | Q05048 | protein_coding | tolerated(0.13) | probably_damaging(0.952) | TCGA-AG-A023-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CSTF1 | insertion | Frame_Shift_Ins | novel | c.950dupA | p.Asn317LysfsTer3 | p.N317Kfs*3 | Q05048 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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