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Gene: CSTB |
Gene summary for CSTB |
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Gene information | Species | Human | Gene symbol | CSTB | Gene ID | 1476 |
Gene name | cystatin B | |
Gene Alias | CPI-B | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P04080 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1476 | CSTB | brca2 | Human | Breast | Precancer | 2.51e-12 | 4.21e-01 | -0.024 |
1476 | CSTB | brca3 | Human | Breast | Precancer | 3.60e-11 | 4.09e-01 | -0.0263 |
1476 | CSTB | NCCBC14 | Human | Breast | DCIS | 4.75e-28 | 4.69e-01 | 0.2021 |
1476 | CSTB | NCCBC5 | Human | Breast | DCIS | 5.17e-13 | 8.75e-03 | 0.2046 |
1476 | CSTB | P1 | Human | Breast | IDC | 1.36e-24 | -4.70e-01 | 0.1527 |
1476 | CSTB | DCIS2 | Human | Breast | DCIS | 3.77e-31 | 1.62e-01 | 0.0085 |
1476 | CSTB | CA_HPV_1 | Human | Cervix | CC | 1.44e-18 | -2.98e-01 | 0.0264 |
1476 | CSTB | CA_HPV_3 | Human | Cervix | CC | 9.58e-08 | -1.80e-01 | 0.0414 |
1476 | CSTB | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 4.11e-03 | -1.68e-01 | 0.0208 |
1476 | CSTB | N_HPV_1 | Human | Cervix | N_HPV | 4.80e-06 | -3.35e-01 | 0.0079 |
1476 | CSTB | CCI_1 | Human | Cervix | CC | 9.28e-11 | -4.55e-02 | 0.528 |
1476 | CSTB | CCI_2 | Human | Cervix | CC | 2.96e-04 | -4.81e-01 | 0.5249 |
1476 | CSTB | CCI_3 | Human | Cervix | CC | 8.58e-23 | -1.01e+00 | 0.516 |
1476 | CSTB | CCII_1 | Human | Cervix | CC | 4.30e-50 | -1.35e+00 | 0.3249 |
1476 | CSTB | Tumor | Human | Cervix | CC | 3.19e-33 | 4.97e-01 | 0.1241 |
1476 | CSTB | sample3 | Human | Cervix | CC | 3.72e-53 | 5.87e-01 | 0.1387 |
1476 | CSTB | H2 | Human | Cervix | HSIL_HPV | 3.72e-11 | 3.00e-01 | 0.0632 |
1476 | CSTB | L1 | Human | Cervix | CC | 4.23e-49 | 7.24e-01 | 0.0802 |
1476 | CSTB | T1 | Human | Cervix | CC | 2.30e-05 | -3.28e-01 | 0.0918 |
1476 | CSTB | T2 | Human | Cervix | CC | 9.17e-04 | -3.88e-01 | 0.0709 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:005254823 | Breast | DCIS | regulation of endopeptidase activity | 83/1390 | 432/18723 | 6.07e-16 | 2.15e-13 | 83 |
GO:004586123 | Breast | DCIS | negative regulation of proteolysis | 63/1390 | 351/18723 | 4.39e-11 | 6.06e-09 | 63 |
GO:005134623 | Breast | DCIS | negative regulation of hydrolase activity | 64/1390 | 379/18723 | 4.32e-10 | 4.80e-08 | 64 |
GO:001046622 | Breast | DCIS | negative regulation of peptidase activity | 49/1390 | 262/18723 | 1.54e-09 | 1.43e-07 | 49 |
GO:001095122 | Breast | DCIS | negative regulation of endopeptidase activity | 47/1390 | 252/18723 | 3.63e-09 | 3.11e-07 | 47 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSTB | insertion | Nonsense_Mutation | novel | c.190_191insCCCCGTTTGTAACGCGGGCCCCGTCCTGAA | p.Phe64delinsSerProPheValThrArgAlaProSerTerIle | p.F64delinsSPFVTRAPS*I | P04080 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
CSTB | SNV | Missense_Mutation | c.226N>A | p.Glu76Lys | p.E76K | P04080 | protein_coding | tolerated(0.13) | benign(0.132) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSTB | SNV | Missense_Mutation | c.215N>G | p.Ser72Cys | p.S72C | P04080 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CSTB | SNV | Missense_Mutation | novel | c.107N>A | p.Pro36His | p.P36H | P04080 | protein_coding | tolerated(0.07) | possibly_damaging(0.8) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CSTB | SNV | Missense_Mutation | novel | c.87G>T | p.Glu29Asp | p.E29D | P04080 | protein_coding | deleterious(0.01) | benign(0.134) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CSTB | SNV | Missense_Mutation | c.227N>G | p.Glu76Gly | p.E76G | P04080 | protein_coding | tolerated(0.05) | possibly_damaging(0.825) | TCGA-ED-A4XI-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CSTB | SNV | Missense_Mutation | novel | c.217N>G | p.Leu73Val | p.L73V | P04080 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-T2-A6X2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CSTB | SNV | Missense_Mutation | c.172C>T | p.His58Tyr | p.H58Y | P04080 | protein_coding | tolerated(0.14) | possibly_damaging(0.664) | TCGA-EJ-5516-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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