Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:1903050 | Colorectum | AD | regulation of proteolysis involved in cellular protein catabolic process | 92/3918 | 221/18723 | 2.04e-12 | 3.19e-10 | 92 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0061136 | Colorectum | AD | regulation of proteasomal protein catabolic process | 75/3918 | 187/18723 | 1.65e-09 | 1.20e-07 | 75 |
GO:2000058 | Colorectum | AD | regulation of ubiquitin-dependent protein catabolic process | 68/3918 | 164/18723 | 1.82e-09 | 1.31e-07 | 68 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:1903364 | Colorectum | AD | positive regulation of cellular protein catabolic process | 62/3918 | 155/18723 | 4.66e-08 | 2.51e-06 | 62 |
GO:0006900 | Colorectum | AD | vesicle budding from membrane | 32/3918 | 61/18723 | 5.38e-08 | 2.81e-06 | 32 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0032434 | Colorectum | AD | regulation of proteasomal ubiquitin-dependent protein catabolic process | 54/3918 | 134/18723 | 2.51e-07 | 1.02e-05 | 54 |
GO:1903052 | Colorectum | AD | positive regulation of proteolysis involved in cellular protein catabolic process | 53/3918 | 133/18723 | 4.93e-07 | 1.85e-05 | 53 |
GO:2000060 | Colorectum | AD | positive regulation of ubiquitin-dependent protein catabolic process | 44/3918 | 107/18723 | 1.65e-06 | 5.03e-05 | 44 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK1D | deletion | Frame_Shift_Del | novel | c.697delA | p.Met233CysfsTer20 | p.M233Cfs*20 | P48730 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
CSNK1D | SNV | Missense_Mutation | | c.870N>T | p.Trp290Cys | p.W290C | P48730 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
CSNK1D | SNV | Missense_Mutation | | c.1094G>C | p.Arg365Thr | p.R365T | P48730 | protein_coding | deleterious_low_confidence(0.05) | benign(0.03) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CSNK1D | SNV | Missense_Mutation | novel | c.379N>T | p.Arg127Trp | p.R127W | P48730 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CSNK1D | SNV | Missense_Mutation | novel | c.1085N>A | p.Gly362Asp | p.G362D | P48730 | protein_coding | tolerated_low_confidence(0.23) | benign(0.192) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CSNK1D | deletion | Frame_Shift_Del | | c.1072delN | p.Arg358GlyfsTer12 | p.R358Gfs*12 | P48730 | protein_coding | | | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CSNK1D | SNV | Missense_Mutation | | c.344G>A | p.Arg115His | p.R115H | P48730 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.995) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CSNK1D | SNV | Missense_Mutation | | c.293G>T | p.Arg98Met | p.R98M | P48730 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CSNK1D | SNV | Missense_Mutation | | c.479N>C | p.Arg160Pro | p.R160P | P48730 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.941) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CSNK1D | SNV | Missense_Mutation | rs765104663 | c.712N>A | p.Glu238Lys | p.E238K | P48730 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.647) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | SB-203580 | SB-203580 | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | TAK-715 | TAK-715 | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | GEFITINIB | GEFITINIB | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | ALSTERPAULLONE | ALSTERPAULLONE | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 178102608 | IC261 | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | (RS)-ROSCOVITINE | (RS)-ROSCOVITINE | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | BMS-345541 | BMS-345541 | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | CYC-116 | CYC-116 | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | DOVITINIB | DOVITINIB | |
1453 | CSNK1D | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | CENISERTIB | CENISERTIB | |