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Gene: COPB1 |
Gene summary for COPB1 |
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Gene information | Species | Human | Gene symbol | COPB1 | Gene ID | 1315 |
Gene name | COPI coat complex subunit beta 1 | |
Gene Alias | BARMACS | |
Cytomap | 11p15.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P53618 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1315 | COPB1 | P22T-E | Human | Esophagus | ESCC | 2.04e-32 | 5.72e-01 | 0.1236 |
1315 | COPB1 | P23T-E | Human | Esophagus | ESCC | 1.04e-10 | 6.90e-01 | 0.108 |
1315 | COPB1 | P24T-E | Human | Esophagus | ESCC | 1.11e-12 | 3.04e-01 | 0.1287 |
1315 | COPB1 | P26T-E | Human | Esophagus | ESCC | 3.02e-27 | 6.21e-01 | 0.1276 |
1315 | COPB1 | P27T-E | Human | Esophagus | ESCC | 6.33e-21 | 3.46e-01 | 0.1055 |
1315 | COPB1 | P28T-E | Human | Esophagus | ESCC | 9.47e-28 | 5.22e-01 | 0.1149 |
1315 | COPB1 | P30T-E | Human | Esophagus | ESCC | 7.62e-19 | 1.01e+00 | 0.137 |
1315 | COPB1 | P31T-E | Human | Esophagus | ESCC | 3.35e-31 | 4.12e-01 | 0.1251 |
1315 | COPB1 | P32T-E | Human | Esophagus | ESCC | 1.11e-46 | 8.90e-01 | 0.1666 |
1315 | COPB1 | P36T-E | Human | Esophagus | ESCC | 2.24e-12 | 5.94e-01 | 0.1187 |
1315 | COPB1 | P37T-E | Human | Esophagus | ESCC | 4.50e-15 | 5.23e-01 | 0.1371 |
1315 | COPB1 | P38T-E | Human | Esophagus | ESCC | 2.64e-02 | 4.45e-02 | 0.127 |
1315 | COPB1 | P39T-E | Human | Esophagus | ESCC | 1.05e-06 | 2.06e-01 | 0.0894 |
1315 | COPB1 | P40T-E | Human | Esophagus | ESCC | 9.00e-07 | 2.44e-01 | 0.109 |
1315 | COPB1 | P42T-E | Human | Esophagus | ESCC | 4.25e-17 | 5.07e-01 | 0.1175 |
1315 | COPB1 | P44T-E | Human | Esophagus | ESCC | 3.19e-11 | 3.42e-01 | 0.1096 |
1315 | COPB1 | P47T-E | Human | Esophagus | ESCC | 2.86e-14 | 2.48e-01 | 0.1067 |
1315 | COPB1 | P48T-E | Human | Esophagus | ESCC | 3.60e-11 | 2.22e-01 | 0.0959 |
1315 | COPB1 | P49T-E | Human | Esophagus | ESCC | 4.85e-13 | 1.59e+00 | 0.1768 |
1315 | COPB1 | P52T-E | Human | Esophagus | ESCC | 6.49e-25 | 6.06e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:000688811 | Liver | Cirrhotic | endoplasmic reticulum to Golgi vesicle-mediated transport | 77/4634 | 130/18723 | 5.78e-17 | 7.56e-15 | 77 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000688821 | Liver | HCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 100/7958 | 130/18723 | 1.15e-15 | 8.67e-14 | 100 |
GO:0006891 | Liver | HCC | intra-Golgi vesicle-mediated transport | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00068888 | Oral cavity | OSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 97/7305 | 130/18723 | 1.42e-16 | 1.15e-14 | 97 |
GO:00068913 | Oral cavity | OSCC | intra-Golgi vesicle-mediated transport | 23/7305 | 33/18723 | 3.47e-04 | 2.12e-03 | 23 |
GO:004819310 | Prostate | BPH | Golgi vesicle transport | 102/3107 | 296/18723 | 3.90e-14 | 4.56e-12 | 102 |
GO:00068887 | Prostate | BPH | endoplasmic reticulum to Golgi vesicle-mediated transport | 46/3107 | 130/18723 | 1.53e-07 | 3.53e-06 | 46 |
GO:00068912 | Prostate | BPH | intra-Golgi vesicle-mediated transport | 12/3107 | 33/18723 | 4.90e-03 | 2.32e-02 | 12 |
GO:004819314 | Prostate | Tumor | Golgi vesicle transport | 105/3246 | 296/18723 | 3.55e-14 | 4.33e-12 | 105 |
GO:000688813 | Prostate | Tumor | endoplasmic reticulum to Golgi vesicle-mediated transport | 49/3246 | 130/18723 | 2.49e-08 | 8.33e-07 | 49 |
GO:00068911 | Prostate | Tumor | intra-Golgi vesicle-mediated transport | 12/3246 | 33/18723 | 7.03e-03 | 3.16e-02 | 12 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000688810 | Skin | cSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 73/4864 | 130/18723 | 2.60e-13 | 1.57e-11 | 73 |
GO:000689112 | Skin | cSCC | intra-Golgi vesicle-mediated transport | 18/4864 | 33/18723 | 4.45e-04 | 3.42e-03 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COPB1 | SNV | Missense_Mutation | novel | c.1750N>A | p.Glu584Lys | p.E584K | P53618 | protein_coding | deleterious(0.01) | benign(0.052) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
COPB1 | SNV | Missense_Mutation | rs377571611 | c.1273N>T | p.Arg425Cys | p.R425C | P53618 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COPB1 | SNV | Missense_Mutation | c.605N>G | p.Gln202Arg | p.Q202R | P53618 | protein_coding | tolerated(0.44) | possibly_damaging(0.464) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COPB1 | SNV | Missense_Mutation | rs370984154 | c.1700N>A | p.Arg567His | p.R567H | P53618 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-C8-A1HL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
COPB1 | SNV | Missense_Mutation | c.2320N>T | p.Pro774Ser | p.P774S | P53618 | protein_coding | tolerated(0.55) | benign(0.129) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
COPB1 | SNV | Missense_Mutation | rs528031760 | c.834N>G | p.Ile278Met | p.I278M | P53618 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-EW-A3E8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
COPB1 | SNV | Missense_Mutation | novel | c.302N>C | p.Val101Ala | p.V101A | P53618 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
COPB1 | SNV | Missense_Mutation | novel | c.385N>A | p.Glu129Lys | p.E129K | P53618 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-ZJ-AAXJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
COPB1 | SNV | Missense_Mutation | c.2446N>C | p.Cys816Arg | p.C816R | P53618 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
COPB1 | SNV | Missense_Mutation | rs754536521 | c.1439N>A | p.Arg480His | p.R480H | P53618 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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