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Gene: CMTR1 |
Gene summary for CMTR1 |
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Gene information | Species | Human | Gene symbol | CMTR1 | Gene ID | 23070 |
Gene name | cap methyltransferase 1 | |
Gene Alias | FTSJD2 | |
Cytomap | 6p21.2 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q8N1G2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23070 | CMTR1 | P26T-E | Human | Esophagus | ESCC | 1.21e-10 | 6.68e-02 | 0.1276 |
23070 | CMTR1 | P27T-E | Human | Esophagus | ESCC | 8.65e-17 | 1.93e-01 | 0.1055 |
23070 | CMTR1 | P28T-E | Human | Esophagus | ESCC | 1.62e-05 | 1.41e-01 | 0.1149 |
23070 | CMTR1 | P30T-E | Human | Esophagus | ESCC | 1.39e-06 | 3.22e-01 | 0.137 |
23070 | CMTR1 | P31T-E | Human | Esophagus | ESCC | 6.00e-09 | 2.25e-01 | 0.1251 |
23070 | CMTR1 | P32T-E | Human | Esophagus | ESCC | 1.81e-05 | 6.58e-02 | 0.1666 |
23070 | CMTR1 | P36T-E | Human | Esophagus | ESCC | 1.24e-05 | 2.50e-01 | 0.1187 |
23070 | CMTR1 | P37T-E | Human | Esophagus | ESCC | 2.57e-16 | 2.09e-01 | 0.1371 |
23070 | CMTR1 | P39T-E | Human | Esophagus | ESCC | 2.29e-02 | 3.61e-02 | 0.0894 |
23070 | CMTR1 | P40T-E | Human | Esophagus | ESCC | 2.78e-03 | 1.29e-01 | 0.109 |
23070 | CMTR1 | P42T-E | Human | Esophagus | ESCC | 1.22e-05 | 1.93e-01 | 0.1175 |
23070 | CMTR1 | P47T-E | Human | Esophagus | ESCC | 1.73e-10 | 1.11e-01 | 0.1067 |
23070 | CMTR1 | P48T-E | Human | Esophagus | ESCC | 1.12e-11 | 1.26e-01 | 0.0959 |
23070 | CMTR1 | P49T-E | Human | Esophagus | ESCC | 1.76e-06 | 8.86e-01 | 0.1768 |
23070 | CMTR1 | P52T-E | Human | Esophagus | ESCC | 1.13e-10 | 2.34e-01 | 0.1555 |
23070 | CMTR1 | P54T-E | Human | Esophagus | ESCC | 9.43e-06 | 2.28e-01 | 0.0975 |
23070 | CMTR1 | P57T-E | Human | Esophagus | ESCC | 3.64e-07 | 1.08e-01 | 0.0926 |
23070 | CMTR1 | P61T-E | Human | Esophagus | ESCC | 1.55e-11 | 2.16e-01 | 0.099 |
23070 | CMTR1 | P62T-E | Human | Esophagus | ESCC | 5.64e-19 | 3.26e-01 | 0.1302 |
23070 | CMTR1 | P65T-E | Human | Esophagus | ESCC | 1.76e-08 | 2.40e-01 | 0.0978 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00800092 | Esophagus | ESCC | mRNA methylation | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00165561 | Esophagus | ESCC | mRNA modification | 21/8552 | 27/18723 | 6.88e-04 | 3.61e-03 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMTR1 | SNV | Missense_Mutation | c.517N>A | p.Asp173Asn | p.D173N | Q8N1G2 | protein_coding | tolerated(0.38) | benign(0.009) | TCGA-A2-A0T6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CMTR1 | SNV | Missense_Mutation | c.1070N>A | p.Gly357Asp | p.G357D | Q8N1G2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CMTR1 | SNV | Missense_Mutation | c.2374N>T | p.His792Tyr | p.H792Y | Q8N1G2 | protein_coding | tolerated(0.72) | benign(0) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CMTR1 | SNV | Missense_Mutation | c.1096N>T | p.Gly366Cys | p.G366C | Q8N1G2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D8-A146-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CMTR1 | insertion | In_Frame_Ins | novel | c.1783_1784insAGT | p.Val595delinsGluLeu | p.V595delinsEL | Q8N1G2 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CMTR1 | insertion | Frame_Shift_Ins | novel | c.1785_1786insACATTTGTTAAATATATATATTTTTTTCTTTTTCTTTT | p.Ser596ThrfsTer43 | p.S596Tfs*43 | Q8N1G2 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CMTR1 | insertion | Nonsense_Mutation | novel | c.719_720insAGTTGAGAGAGTTATTGAGCAGCCTGTGTAGGGTCACACAGTGA | p.Met240IlefsTer11 | p.M240Ifs*11 | Q8N1G2 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
CMTR1 | insertion | Frame_Shift_Ins | novel | c.910_911insATATTCTGTTCAGTAGGACTCTTGAAAGGCAGGATAT | p.Gly304AspfsTer15 | p.G304Dfs*15 | Q8N1G2 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
CMTR1 | SNV | Missense_Mutation | c.2381N>C | p.Cys794Ser | p.C794S | Q8N1G2 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
CMTR1 | SNV | Missense_Mutation | c.2052N>T | p.Glu684Asp | p.E684D | Q8N1G2 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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