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Gene: CHST11 |
Gene summary for CHST11 |
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Gene information | Species | Human | Gene symbol | CHST11 | Gene ID | 50515 |
Gene name | carbohydrate sulfotransferase 11 | |
Gene Alias | C4ST | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q9NPF2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50515 | CHST11 | P48T-E | Human | Esophagus | ESCC | 1.31e-02 | 6.38e-02 | 0.0959 |
50515 | CHST11 | P49T-E | Human | Esophagus | ESCC | 2.05e-05 | 3.18e-01 | 0.1768 |
50515 | CHST11 | P52T-E | Human | Esophagus | ESCC | 2.07e-21 | 6.06e-01 | 0.1555 |
50515 | CHST11 | P56T-E | Human | Esophagus | ESCC | 3.24e-15 | 3.03e+00 | 0.1613 |
50515 | CHST11 | P57T-E | Human | Esophagus | ESCC | 4.17e-02 | 3.00e-02 | 0.0926 |
50515 | CHST11 | P62T-E | Human | Esophagus | ESCC | 6.80e-04 | 2.28e-01 | 0.1302 |
50515 | CHST11 | P76T-E | Human | Esophagus | ESCC | 3.00e-18 | 5.89e-01 | 0.1207 |
50515 | CHST11 | P79T-E | Human | Esophagus | ESCC | 1.41e-09 | 9.63e-02 | 0.1154 |
50515 | CHST11 | P83T-E | Human | Esophagus | ESCC | 4.96e-11 | 4.32e-01 | 0.1738 |
50515 | CHST11 | P126T-E | Human | Esophagus | ESCC | 1.55e-02 | 1.85e-01 | 0.1125 |
50515 | CHST11 | P130T-E | Human | Esophagus | ESCC | 5.66e-04 | 4.86e-02 | 0.1676 |
50515 | CHST11 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.55e-17 | 8.38e-01 | -0.2116 |
50515 | CHST11 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.62e-10 | 8.24e-01 | -0.1941 |
50515 | CHST11 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 3.96e-11 | 9.23e-01 | -0.2107 |
50515 | CHST11 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.15e-12 | 8.02e-01 | -0.2119 |
50515 | CHST11 | C04 | Human | Oral cavity | OSCC | 5.05e-17 | 6.69e-01 | 0.2633 |
50515 | CHST11 | C21 | Human | Oral cavity | OSCC | 5.85e-26 | 7.69e-01 | 0.2678 |
50515 | CHST11 | C30 | Human | Oral cavity | OSCC | 1.69e-19 | 9.08e-01 | 0.3055 |
50515 | CHST11 | C43 | Human | Oral cavity | OSCC | 3.44e-02 | 9.01e-02 | 0.1704 |
50515 | CHST11 | C51 | Human | Oral cavity | OSCC | 3.11e-23 | 9.78e-01 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:00715609 | Esophagus | ESCC | cellular response to transforming growth factor beta stimulus | 151/8552 | 250/18723 | 1.78e-06 | 2.10e-05 | 151 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00071799 | Esophagus | ESCC | transforming growth factor beta receptor signaling pathway | 121/8552 | 198/18723 | 8.26e-06 | 8.03e-05 | 121 |
GO:00097919 | Esophagus | ESCC | post-embryonic development | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00487367 | Esophagus | ESCC | appendage development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00601737 | Esophagus | ESCC | limb development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00170156 | Esophagus | ESCC | regulation of transforming growth factor beta receptor signaling pathway | 75/8552 | 128/18723 | 2.19e-03 | 9.71e-03 | 75 |
GO:19038447 | Esophagus | ESCC | regulation of cellular response to transforming growth factor beta stimulus | 76/8552 | 131/18723 | 2.96e-03 | 1.24e-02 | 76 |
GO:00487052 | Esophagus | ESCC | skeletal system morphogenesis | 120/8552 | 220/18723 | 4.90e-03 | 1.89e-02 | 120 |
GO:0006029 | Esophagus | ESCC | proteoglycan metabolic process | 48/8552 | 79/18723 | 4.93e-03 | 1.89e-02 | 48 |
GO:0030166 | Esophagus | ESCC | proteoglycan biosynthetic process | 35/8552 | 56/18723 | 8.30e-03 | 2.94e-02 | 35 |
GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00532 | Oral cavity | OSCC | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 16/3704 | 21/8465 | 2.61e-03 | 6.77e-03 | 3.45e-03 | 16 |
hsa005321 | Oral cavity | OSCC | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 16/3704 | 21/8465 | 2.61e-03 | 6.77e-03 | 3.45e-03 | 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHST11 | SNV | Missense_Mutation | c.237N>C | p.Gln79His | p.Q79H | Q9NPF2 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CHST11 | SNV | Missense_Mutation | c.937N>A | p.Glu313Lys | p.E313K | Q9NPF2 | protein_coding | tolerated(0.26) | benign(0.124) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHST11 | SNV | Missense_Mutation | c.751C>T | p.Arg251Trp | p.R251W | Q9NPF2 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
CHST11 | deletion | Frame_Shift_Del | novel | c.769delN | p.Glu257AsnfsTer43 | p.E257Nfs*43 | Q9NPF2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CHST11 | SNV | Missense_Mutation | c.528G>C | p.Leu176Phe | p.L176F | Q9NPF2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CHST11 | SNV | Missense_Mutation | novel | c.311C>A | p.Pro104His | p.P104H | Q9NPF2 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-C5-A1MJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CHST11 | SNV | Missense_Mutation | c.83N>G | p.Leu28Arg | p.L28R | Q9NPF2 | protein_coding | deleterious(0) | benign(0.125) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHST11 | SNV | Missense_Mutation | novel | c.427N>G | p.Lys143Glu | p.K143E | Q9NPF2 | protein_coding | tolerated(0.24) | possibly_damaging(0.534) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHST11 | SNV | Missense_Mutation | rs759769235 | c.295N>T | p.Arg99Trp | p.R99W | Q9NPF2 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AA-3495-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHST11 | SNV | Missense_Mutation | c.398N>A | p.Arg133Gln | p.R133Q | Q9NPF2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
50515 | CHST11 | ENZYME, DRUGGABLE GENOME | CHONDROITIN SULFATE | 16079159 | ||
50515 | CHST11 | ENZYME, DRUGGABLE GENOME | CHONDROITIN | 11056388 |
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