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Gene: CHIC2 |
Gene summary for CHIC2 |
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Gene information | Species | Human | Gene symbol | CHIC2 | Gene ID | 26511 |
Gene name | cysteine rich hydrophobic domain 2 | |
Gene Alias | BTL | |
Cytomap | 4q12 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9UKJ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26511 | CHIC2 | P5T-E | Human | Esophagus | ESCC | 1.75e-16 | 1.66e-01 | 0.1327 |
26511 | CHIC2 | P8T-E | Human | Esophagus | ESCC | 1.90e-24 | 6.45e-01 | 0.0889 |
26511 | CHIC2 | P9T-E | Human | Esophagus | ESCC | 5.92e-18 | 4.64e-01 | 0.1131 |
26511 | CHIC2 | P10T-E | Human | Esophagus | ESCC | 1.59e-19 | 3.03e-01 | 0.116 |
26511 | CHIC2 | P11T-E | Human | Esophagus | ESCC | 1.94e-25 | 6.69e-01 | 0.1426 |
26511 | CHIC2 | P12T-E | Human | Esophagus | ESCC | 1.80e-38 | 8.20e-01 | 0.1122 |
26511 | CHIC2 | P15T-E | Human | Esophagus | ESCC | 2.09e-25 | 7.09e-01 | 0.1149 |
26511 | CHIC2 | P16T-E | Human | Esophagus | ESCC | 4.92e-30 | 4.02e-01 | 0.1153 |
26511 | CHIC2 | P17T-E | Human | Esophagus | ESCC | 9.81e-03 | 2.54e-01 | 0.1278 |
26511 | CHIC2 | P19T-E | Human | Esophagus | ESCC | 4.19e-08 | 4.31e-01 | 0.1662 |
26511 | CHIC2 | P20T-E | Human | Esophagus | ESCC | 2.40e-18 | 3.57e-01 | 0.1124 |
26511 | CHIC2 | P21T-E | Human | Esophagus | ESCC | 1.46e-45 | 8.99e-01 | 0.1617 |
26511 | CHIC2 | P22T-E | Human | Esophagus | ESCC | 1.45e-30 | 6.53e-01 | 0.1236 |
26511 | CHIC2 | P23T-E | Human | Esophagus | ESCC | 8.94e-22 | 7.41e-01 | 0.108 |
26511 | CHIC2 | P24T-E | Human | Esophagus | ESCC | 3.23e-24 | 2.65e-01 | 0.1287 |
26511 | CHIC2 | P26T-E | Human | Esophagus | ESCC | 1.96e-59 | 1.17e+00 | 0.1276 |
26511 | CHIC2 | P27T-E | Human | Esophagus | ESCC | 1.61e-21 | 4.83e-01 | 0.1055 |
26511 | CHIC2 | P28T-E | Human | Esophagus | ESCC | 3.49e-61 | 1.43e+00 | 0.1149 |
26511 | CHIC2 | P30T-E | Human | Esophagus | ESCC | 1.44e-23 | 1.13e+00 | 0.137 |
26511 | CHIC2 | P31T-E | Human | Esophagus | ESCC | 5.87e-17 | 4.70e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHIC2 | SNV | Missense_Mutation | c.335N>A | p.Arg112Gln | p.R112Q | Q9UKJ5 | protein_coding | tolerated(0.3) | possibly_damaging(0.714) | TCGA-BH-A204-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHIC2 | SNV | Missense_Mutation | novel | c.38N>C | p.Asp13Ala | p.D13A | Q9UKJ5 | protein_coding | tolerated(0.23) | probably_damaging(0.968) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHIC2 | SNV | Missense_Mutation | rs750921405 | c.488N>A | p.Arg163Gln | p.R163Q | Q9UKJ5 | protein_coding | tolerated(0.2) | benign(0.019) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CHIC2 | SNV | Missense_Mutation | c.493N>T | p.Asp165Tyr | p.D165Y | Q9UKJ5 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CHIC2 | SNV | Missense_Mutation | c.464N>A | p.Phe155Tyr | p.F155Y | Q9UKJ5 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CHIC2 | SNV | Missense_Mutation | novel | c.338G>T | p.Arg113Ile | p.R113I | Q9UKJ5 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHIC2 | SNV | Missense_Mutation | c.250C>T | p.Arg84Cys | p.R84C | Q9UKJ5 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHIC2 | SNV | Missense_Mutation | rs772144534 | c.131N>A | p.Ser44Asn | p.S44N | Q9UKJ5 | protein_coding | tolerated(0.31) | benign(0.096) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CHIC2 | SNV | Missense_Mutation | c.146N>A | p.Ser49Tyr | p.S49Y | Q9UKJ5 | protein_coding | deleterious(0.01) | possibly_damaging(0.544) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHIC2 | SNV | Missense_Mutation | novel | c.197C>T | p.Ala66Val | p.A66V | Q9UKJ5 | protein_coding | tolerated(0.14) | benign(0.238) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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