Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: CEP70

Gene summary for CEP70

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CEP70

Gene ID

80321

Gene namecentrosomal protein 70
Gene AliasBITE
Cytomap3q22.3
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

Q8NHQ1


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
80321CEP70A002-C-203HumanColorectumFAP7.11e-03-2.36e-010.2786
80321CEP70A001-C-119HumanColorectumFAP6.72e-05-3.38e-01-0.1557
80321CEP70A001-C-108HumanColorectumFAP9.79e-10-2.66e-01-0.0272
80321CEP70A002-C-205HumanColorectumFAP4.68e-15-3.81e-01-0.1236
80321CEP70A015-C-005HumanColorectumFAP8.02e-03-2.54e-01-0.0336
80321CEP70A015-C-006HumanColorectumFAP1.09e-12-4.94e-01-0.0994
80321CEP70A015-C-106HumanColorectumFAP1.31e-07-2.68e-01-0.0511
80321CEP70A002-C-114HumanColorectumFAP5.87e-12-3.62e-01-0.1561
80321CEP70A015-C-104HumanColorectumFAP2.89e-17-3.73e-01-0.1899
80321CEP70A001-C-014HumanColorectumFAP8.50e-09-2.38e-010.0135
80321CEP70A002-C-016HumanColorectumFAP1.66e-13-2.54e-010.0521
80321CEP70A015-C-002HumanColorectumFAP1.06e-08-4.25e-01-0.0763
80321CEP70A001-C-007HumanColorectumCRC2.26e-04-4.75e-010.1899
80321CEP70A001-C-203HumanColorectumFAP3.71e-06-1.80e-01-0.0481
80321CEP70A002-C-116HumanColorectumFAP6.92e-21-3.70e-01-0.0452
80321CEP70A014-C-008HumanColorectumFAP1.91e-08-2.85e-01-0.191
80321CEP70A018-E-020HumanColorectumFAP7.23e-13-3.69e-01-0.2034
80321CEP70F034HumanColorectumFAP1.90e-11-2.14e-01-0.0665
80321CEP70F072BHumanColorectumFAP2.73e-08-2.68e-010.257
80321CEP70CRC-1-8810HumanColorectumCRC3.62e-19-5.25e-010.6257
Page: 1 2 3 4 5 6 7 8 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00705074CervixCCregulation of microtubule cytoskeleton organization32/2311148/187231.02e-038.51e-0332
GO:0070507ColorectumADregulation of microtubule cytoskeleton organization44/3918148/187237.05e-034.31e-0244
GO:00705071ColorectumCRCregulation of microtubule cytoskeleton organization30/2078148/187237.75e-049.87e-0330
GO:00705078EsophagusESCCregulation of microtubule cytoskeleton organization99/8552148/187231.43e-072.29e-0699
GO:00328864EsophagusESCCregulation of microtubule-based process134/8552240/187239.44e-044.80e-03134
GO:00705073LungIACregulation of microtubule cytoskeleton organization29/2061148/187231.44e-031.55e-0229
GO:0060271LungIACcilium assembly55/2061337/187231.84e-031.88e-0255
GO:0044782LungIACcilium organization58/2061368/187233.15e-032.75e-0258
GO:007050712LungAISregulation of microtubule cytoskeleton organization28/1849148/187235.69e-048.89e-0328
GO:00602711LungMIACcilium assembly37/967337/187231.29e-059.85e-0437
GO:00447821LungMIACcilium organization38/967368/187233.93e-052.08e-0338
GO:007050721LungMIACregulation of microtubule cytoskeleton organization18/967148/187236.34e-041.55e-0218
GO:00328861LungMIACregulation of microtubule-based process23/967240/187233.27e-034.31e-0223
GO:00705077Oral cavityOSCCregulation of microtubule cytoskeleton organization84/7305148/187238.80e-069.33e-0584
GO:00328863Oral cavityOSCCregulation of microtubule-based process115/7305240/187232.95e-031.28e-02115
GO:00705076ProstateBPHregulation of microtubule cytoskeleton organization48/3107148/187231.57e-062.67e-0548
GO:00328862ProstateBPHregulation of microtubule-based process64/3107240/187234.93e-055.11e-0464
GO:007050714ProstateTumorregulation of microtubule cytoskeleton organization47/3246148/187231.29e-051.78e-0447
GO:003288611ProstateTumorregulation of microtubule-based process65/3246240/187231.00e-049.73e-0465
GO:007050717ThyroidPTCregulation of microtubule cytoskeleton organization80/5968148/187231.79e-084.19e-0780
Page: 1 2 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CEP70SNVMissense_Mutationnovelc.546N>Tp.Leu182Phep.L182FQ8NHQ1protein_codingtolerated(0.18)benign(0.024)TCGA-3C-AALI-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPoly EComplete Response
CEP70SNVMissense_Mutationc.1717N>Gp.Leu573Valp.L573VQ8NHQ1protein_codingdeleterious(0)probably_damaging(0.939)TCGA-A2-A0T0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
CEP70SNVMissense_Mutationc.146G>Ap.Arg49Lysp.R49KQ8NHQ1protein_codingtolerated(0.83)benign(0.007)TCGA-A2-A259-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
CEP70SNVMissense_Mutationnovelc.1436N>Ap.Val479Glup.V479EQ8NHQ1protein_codingdeleterious(0)probably_damaging(0.997)TCGA-A2-A4S1-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CEP70SNVMissense_Mutationrs779132771c.565N>Tp.Arg189Cysp.R189CQ8NHQ1protein_codingdeleterious(0)probably_damaging(0.992)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CEP70SNVMissense_Mutationc.1644N>Gp.Asp548Glup.D548EQ8NHQ1protein_codingdeleterious(0)benign(0.066)TCGA-AR-A0TZ-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificDoxorubicinPD
CEP70SNVMissense_Mutationc.1199N>Ap.Ala400Glup.A400EQ8NHQ1protein_codingdeleterious(0)benign(0.354)TCGA-BH-A18H-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
CEP70SNVMissense_Mutationnovelc.398C>Tp.Ser133Leup.S133LQ8NHQ1protein_codingtolerated(0.11)probably_damaging(0.996)TCGA-BH-A2L8-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
CEP70SNVMissense_Mutationnovelc.665N>Gp.Ser222Cysp.S222CQ8NHQ1protein_codingtolerated(0.06)benign(0.01)TCGA-PE-A5DE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
CEP70insertionFrame_Shift_Insnovelc.1127_1128insAACCp.Gln377ThrfsTer5p.Q377Tfs*5Q8NHQ1protein_codingTCGA-AR-A0U0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1