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Gene: CD82 |
Gene summary for CD82 |
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Gene information | Species | Human | Gene symbol | CD82 | Gene ID | 3732 |
Gene name | CD82 molecule | |
Gene Alias | 4F9 | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P27701 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3732 | CD82 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.66e-04 | 1.98e-01 | 0.294 |
3732 | CD82 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.81e-06 | 9.05e-01 | 0.3487 |
3732 | CD82 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.31e-05 | 2.61e-01 | 0.281 |
3732 | CD82 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.67e-04 | 2.62e-01 | 0.3859 |
3732 | CD82 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.36e-09 | 4.93e-01 | 0.2585 |
3732 | CD82 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.98e-07 | 2.74e-01 | 0.3005 |
3732 | CD82 | LZE2T | Human | Esophagus | ESCC | 1.97e-02 | -4.15e-02 | 0.082 |
3732 | CD82 | LZE4T | Human | Esophagus | ESCC | 1.48e-07 | 3.18e-01 | 0.0811 |
3732 | CD82 | LZE7T | Human | Esophagus | ESCC | 1.41e-02 | -1.41e-01 | 0.0667 |
3732 | CD82 | LZE8T | Human | Esophagus | ESCC | 8.67e-03 | 5.00e-01 | 0.067 |
3732 | CD82 | LZE20T | Human | Esophagus | ESCC | 2.58e-04 | 4.19e-01 | 0.0662 |
3732 | CD82 | LZE24T | Human | Esophagus | ESCC | 1.82e-04 | 1.90e-01 | 0.0596 |
3732 | CD82 | P1T-E | Human | Esophagus | ESCC | 8.77e-03 | 3.88e-01 | 0.0875 |
3732 | CD82 | P2T-E | Human | Esophagus | ESCC | 2.45e-48 | 1.62e+00 | 0.1177 |
3732 | CD82 | P4T-E | Human | Esophagus | ESCC | 4.24e-13 | 4.06e-01 | 0.1323 |
3732 | CD82 | P8T-E | Human | Esophagus | ESCC | 6.00e-26 | 1.45e+00 | 0.0889 |
3732 | CD82 | P10T-E | Human | Esophagus | ESCC | 2.50e-04 | -1.38e-01 | 0.116 |
3732 | CD82 | P11T-E | Human | Esophagus | ESCC | 1.43e-21 | 1.54e+00 | 0.1426 |
3732 | CD82 | P12T-E | Human | Esophagus | ESCC | 3.53e-08 | 6.03e-02 | 0.1122 |
3732 | CD82 | P15T-E | Human | Esophagus | ESCC | 1.65e-08 | 4.37e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa041156 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa041159 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411514 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411523 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa0411533 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD82 | SNV | Missense_Mutation | c.240N>C | p.Glu80Asp | p.E80D | P27701 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-A6-6140-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | SD | |
CD82 | SNV | Missense_Mutation | novel | c.692N>C | p.Ile231Thr | p.I231T | P27701 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CD82 | SNV | Missense_Mutation | rs766230830 | c.775N>A | p.Glu259Lys | p.E259K | P27701 | protein_coding | deleterious(0.04) | possibly_damaging(0.799) | TCGA-AJ-A3OL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
CD82 | SNV | Missense_Mutation | c.664N>A | p.Ala222Thr | p.A222T | P27701 | protein_coding | tolerated(0.42) | benign(0.02) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CD82 | SNV | Missense_Mutation | rs761257124 | c.37N>A | p.Leu13Ile | p.L13I | P27701 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CD82 | SNV | Missense_Mutation | novel | c.163N>A | p.Gly55Arg | p.G55R | P27701 | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD82 | SNV | Missense_Mutation | c.304N>A | p.Ala102Thr | p.A102T | P27701 | protein_coding | tolerated(0.12) | possibly_damaging(0.554) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CD82 | SNV | Missense_Mutation | novel | c.547N>A | p.Asp183Asn | p.D183N | P27701 | protein_coding | tolerated(0.94) | possibly_damaging(0.494) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD82 | SNV | Missense_Mutation | c.502C>T | p.Pro168Ser | p.P168S | P27701 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD82 | SNV | Missense_Mutation | novel | c.682N>A | p.Leu228Met | p.L228M | P27701 | protein_coding | deleterious(0.02) | possibly_damaging(0.844) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3732 | CD82 | DRUGGABLE GENOME, CELL SURFACE | NERVE GROWTH FACTOR | 10353759 |
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