Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: CCDC64B

Gene summary for CCDC64B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CCDC64B

Gene ID

146439

Gene nameBICD family like cargo adaptor 2
Gene AliasBICDR-2
Cytomap16p13.3
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

A1A5D9


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
146439CCDC64BP36T-EHumanEsophagusESCC2.11e-032.08e-010.1187
146439CCDC64BP37T-EHumanEsophagusESCC1.42e-102.94e-010.1371
146439CCDC64BP38T-EHumanEsophagusESCC3.67e-052.49e-010.127
146439CCDC64BP39T-EHumanEsophagusESCC7.28e-266.14e-010.0894
146439CCDC64BP40T-EHumanEsophagusESCC1.47e-072.71e-010.109
146439CCDC64BP42T-EHumanEsophagusESCC8.55e-051.86e-010.1175
146439CCDC64BP44T-EHumanEsophagusESCC1.25e-083.12e-010.1096
146439CCDC64BP47T-EHumanEsophagusESCC9.35e-102.91e-010.1067
146439CCDC64BP48T-EHumanEsophagusESCC1.88e-112.38e-010.0959
146439CCDC64BP52T-EHumanEsophagusESCC1.78e-031.22e-010.1555
146439CCDC64BP54T-EHumanEsophagusESCC3.18e-245.82e-010.0975
146439CCDC64BP56T-EHumanEsophagusESCC6.66e-055.31e-010.1613
146439CCDC64BP57T-EHumanEsophagusESCC1.75e-254.90e-010.0926
146439CCDC64BP61T-EHumanEsophagusESCC2.46e-173.52e-010.099
146439CCDC64BP62T-EHumanEsophagusESCC3.28e-387.12e-010.1302
146439CCDC64BP65T-EHumanEsophagusESCC3.23e-153.61e-010.0978
146439CCDC64BP74T-EHumanEsophagusESCC1.08e-195.47e-010.1479
146439CCDC64BP75T-EHumanEsophagusESCC7.66e-491.08e+000.1125
146439CCDC64BP76T-EHumanEsophagusESCC1.53e-194.07e-010.1207
146439CCDC64BP79T-EHumanEsophagusESCC8.08e-194.28e-010.1154
Page: 1 2 3 4 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa048144EndometriumAEHMotor proteins42/1197193/84652.41e-031.42e-021.04e-0242
hsa0481411EndometriumAEHMotor proteins42/1197193/84652.41e-031.42e-021.04e-0242
hsa048142EndometriumEECMotor proteins42/1237193/84654.43e-032.39e-021.78e-0242
hsa048143EndometriumEECMotor proteins42/1237193/84654.43e-032.39e-021.78e-0242
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
Page: 1 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1