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Gene: CAPS |
Gene summary for CAPS |
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Gene information | Species | Human | Gene symbol | CAPS | Gene ID | 828 |
Gene name | calcyphosine | |
Gene Alias | CAPS1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | K7EL21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
828 | CAPS | P2 | Human | Breast | IDC | 4.38e-38 | 1.03e+00 | 0.21 |
828 | CAPS | P3 | Human | Breast | IDC | 6.38e-06 | 5.38e-01 | 0.1542 |
828 | CAPS | DCIS2 | Human | Breast | DCIS | 1.18e-04 | 1.39e-02 | 0.0085 |
828 | CAPS | AEH-subject2 | Human | Endometrium | AEH | 1.40e-06 | 5.04e-01 | -0.2525 |
828 | CAPS | AEH-subject3 | Human | Endometrium | AEH | 4.68e-61 | 1.07e+00 | -0.2576 |
828 | CAPS | AEH-subject4 | Human | Endometrium | AEH | 3.46e-06 | 5.52e-01 | -0.2657 |
828 | CAPS | EEC-subject2 | Human | Endometrium | EEC | 8.88e-08 | 4.41e-01 | -0.2607 |
828 | CAPS | EEC-subject3 | Human | Endometrium | EEC | 4.24e-13 | -3.24e-01 | -0.2525 |
828 | CAPS | EEC-subject4 | Human | Endometrium | EEC | 1.07e-21 | 7.32e-01 | -0.2571 |
828 | CAPS | GSM5276934 | Human | Endometrium | EEC | 3.76e-21 | -5.31e-01 | -0.0913 |
828 | CAPS | GSM5276935 | Human | Endometrium | EEC | 1.12e-16 | 6.39e-01 | -0.123 |
828 | CAPS | GSM5276937 | Human | Endometrium | EEC | 9.04e-10 | -9.03e-02 | -0.0897 |
828 | CAPS | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.25e-08 | 5.91e-02 | -0.1869 |
828 | CAPS | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.17e-06 | -3.39e-02 | -0.1875 |
828 | CAPS | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.61e-09 | 6.28e-02 | -0.1883 |
828 | CAPS | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.23e-19 | 4.93e-01 | -0.1934 |
828 | CAPS | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.16e-19 | 1.61e-01 | -0.1917 |
828 | CAPS | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.31e-15 | 1.27e-01 | -0.1916 |
828 | CAPS | LZE7T | Human | Esophagus | ESCC | 1.05e-02 | 3.20e-01 | 0.0667 |
828 | CAPS | P2T-E | Human | Esophagus | ESCC | 9.33e-13 | 1.98e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPS | SNV | Missense_Mutation | novel | c.396N>A | p.Phe132Leu | p.F132L | protein_coding | tolerated(0.46) | benign(0.001) | TCGA-AR-A0TQ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CAPS | deletion | In_Frame_Del | c.480_482delCGG | p.Ser160_Gly161delinsArg | p.S160_G161delinsR | protein_coding | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
CAPS | SNV | Missense_Mutation | rs199545548 | c.508C>T | p.Arg170Trp | p.R170W | protein_coding | deleterious(0.02) | benign(0.033) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
CAPS | SNV | Missense_Mutation | rs147762651 | c.721N>A | p.Gly241Arg | p.G241R | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-D5-6539-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CAPS | SNV | Missense_Mutation | novel | c.569A>G | p.Lys190Arg | p.K190R | protein_coding | deleterious(0.02) | benign(0.4) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CAPS | deletion | In_Frame_Del | novel | c.307_312delTCCCGC | p.Ser103_Arg104del | p.S103_R104del | protein_coding | TCGA-A6-3807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD | |||
CAPS | SNV | Missense_Mutation | novel | c.213G>T | p.Arg71Ser | p.R71S | protein_coding | tolerated(0.22) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CAPS | SNV | Missense_Mutation | c.317C>A | p.Ala106Asp | p.A106D | protein_coding | deleterious(0) | benign(0.076) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
CAPS | SNV | Missense_Mutation | novel | c.341N>T | p.Arg114Met | p.R114M | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CAPS | SNV | Missense_Mutation | novel | c.476G>A | p.Gly159Asp | p.G159D | protein_coding | deleterious(0.04) | probably_damaging(0.955) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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