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Gene: C6orf226 |
Gene summary for C6ORF226 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C6orf226 | Gene ID | 441150 |
Gene name | chromosome 6 open reading frame 226 | |
Gene Alias | C6orf226 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q5I0X4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
441150 | C6orf226 | P16T-E | Human | Esophagus | ESCC | 1.90e-28 | 4.20e-01 | 0.1153 |
441150 | C6orf226 | P17T-E | Human | Esophagus | ESCC | 2.81e-10 | 2.54e-01 | 0.1278 |
441150 | C6orf226 | P19T-E | Human | Esophagus | ESCC | 1.70e-02 | 2.22e-01 | 0.1662 |
441150 | C6orf226 | P20T-E | Human | Esophagus | ESCC | 8.18e-04 | 6.65e-02 | 0.1124 |
441150 | C6orf226 | P21T-E | Human | Esophagus | ESCC | 3.89e-22 | 3.21e-01 | 0.1617 |
441150 | C6orf226 | P22T-E | Human | Esophagus | ESCC | 4.76e-48 | 8.12e-01 | 0.1236 |
441150 | C6orf226 | P23T-E | Human | Esophagus | ESCC | 1.15e-32 | 7.31e-01 | 0.108 |
441150 | C6orf226 | P24T-E | Human | Esophagus | ESCC | 3.94e-17 | 2.18e-01 | 0.1287 |
441150 | C6orf226 | P26T-E | Human | Esophagus | ESCC | 9.77e-45 | 8.48e-01 | 0.1276 |
441150 | C6orf226 | P27T-E | Human | Esophagus | ESCC | 7.42e-25 | 3.75e-01 | 0.1055 |
441150 | C6orf226 | P28T-E | Human | Esophagus | ESCC | 1.52e-13 | 2.56e-01 | 0.1149 |
441150 | C6orf226 | P30T-E | Human | Esophagus | ESCC | 9.31e-27 | 7.66e-01 | 0.137 |
441150 | C6orf226 | P31T-E | Human | Esophagus | ESCC | 1.29e-40 | 7.31e-01 | 0.1251 |
441150 | C6orf226 | P32T-E | Human | Esophagus | ESCC | 1.62e-32 | 5.57e-01 | 0.1666 |
441150 | C6orf226 | P36T-E | Human | Esophagus | ESCC | 3.54e-05 | 2.13e-01 | 0.1187 |
441150 | C6orf226 | P37T-E | Human | Esophagus | ESCC | 2.11e-18 | 1.53e-01 | 0.1371 |
441150 | C6orf226 | P38T-E | Human | Esophagus | ESCC | 3.45e-05 | 2.30e-01 | 0.127 |
441150 | C6orf226 | P39T-E | Human | Esophagus | ESCC | 7.86e-21 | 1.64e-01 | 0.0894 |
441150 | C6orf226 | P40T-E | Human | Esophagus | ESCC | 1.86e-17 | 4.54e-01 | 0.109 |
441150 | C6orf226 | P42T-E | Human | Esophagus | ESCC | 3.39e-15 | 3.96e-01 | 0.1175 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C6orf226 | SNV | Missense_Mutation | novel | c.47N>T | p.Ser16Leu | p.S16L | Q5I0X4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.022) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C6orf226 | SNV | Missense_Mutation | novel | c.104N>T | p.Pro35Leu | p.P35L | Q5I0X4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C6orf226 | SNV | Missense_Mutation | c.101N>C | p.Leu34Pro | p.L34P | Q5I0X4 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.873) | TCGA-MI-A75C-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C6orf226 | SNV | Missense_Mutation | c.41C>G | p.Ser14Cys | p.S14C | Q5I0X4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.505) | TCGA-91-6840-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C6orf226 | SNV | Missense_Mutation | novel | c.262N>A | p.Glu88Lys | p.E88K | Q5I0X4 | protein_coding | tolerated_low_confidence(0.16) | benign(0.003) | TCGA-96-A4JL-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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