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Gene: C4orf33 |
Gene summary for C4ORF33 |
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Gene information | Species | Human | Gene symbol | C4orf33 | Gene ID | 132321 |
Gene name | chromosome 4 open reading frame 33 | |
Gene Alias | C4orf33 | |
Cytomap | 4q28.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N1A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132321 | C4orf33 | P40T-E | Human | Esophagus | ESCC | 1.78e-02 | 6.90e-02 | 0.109 |
132321 | C4orf33 | P42T-E | Human | Esophagus | ESCC | 8.53e-06 | 8.98e-02 | 0.1175 |
132321 | C4orf33 | P44T-E | Human | Esophagus | ESCC | 6.73e-03 | 3.15e-02 | 0.1096 |
132321 | C4orf33 | P47T-E | Human | Esophagus | ESCC | 6.92e-06 | 9.30e-02 | 0.1067 |
132321 | C4orf33 | P48T-E | Human | Esophagus | ESCC | 1.89e-03 | 2.26e-02 | 0.0959 |
132321 | C4orf33 | P52T-E | Human | Esophagus | ESCC | 1.68e-03 | 1.03e-01 | 0.1555 |
132321 | C4orf33 | P62T-E | Human | Esophagus | ESCC | 4.45e-50 | 7.69e-01 | 0.1302 |
132321 | C4orf33 | P65T-E | Human | Esophagus | ESCC | 2.25e-04 | 2.78e-02 | 0.0978 |
132321 | C4orf33 | P74T-E | Human | Esophagus | ESCC | 1.72e-09 | 2.23e-01 | 0.1479 |
132321 | C4orf33 | P75T-E | Human | Esophagus | ESCC | 7.43e-13 | 2.20e-01 | 0.1125 |
132321 | C4orf33 | P76T-E | Human | Esophagus | ESCC | 7.20e-10 | 7.32e-02 | 0.1207 |
132321 | C4orf33 | P79T-E | Human | Esophagus | ESCC | 9.03e-05 | 3.03e-02 | 0.1154 |
132321 | C4orf33 | P80T-E | Human | Esophagus | ESCC | 4.98e-17 | 4.28e-01 | 0.155 |
132321 | C4orf33 | P82T-E | Human | Esophagus | ESCC | 9.15e-04 | 3.42e-01 | 0.1072 |
132321 | C4orf33 | P83T-E | Human | Esophagus | ESCC | 4.24e-09 | 2.97e-01 | 0.1738 |
132321 | C4orf33 | P84T-E | Human | Esophagus | ESCC | 2.28e-02 | 1.14e-01 | 0.0933 |
132321 | C4orf33 | P89T-E | Human | Esophagus | ESCC | 1.94e-03 | 2.84e-01 | 0.1752 |
132321 | C4orf33 | P91T-E | Human | Esophagus | ESCC | 2.23e-08 | 5.57e-01 | 0.1828 |
132321 | C4orf33 | P107T-E | Human | Esophagus | ESCC | 3.53e-03 | 3.04e-03 | 0.171 |
132321 | C4orf33 | P127T-E | Human | Esophagus | ESCC | 2.46e-07 | 1.15e-01 | 0.0826 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf33 | SNV | Missense_Mutation | c.226N>C | p.Glu76Gln | p.E76Q | Q8N1A6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C4orf33 | SNV | Missense_Mutation | c.83G>A | p.Arg28Lys | p.R28K | Q8N1A6 | protein_coding | tolerated(0.62) | benign(0) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
C4orf33 | SNV | Missense_Mutation | c.83G>A | p.Arg28Lys | p.R28K | Q8N1A6 | protein_coding | tolerated(0.62) | benign(0) | TCGA-B5-A0K8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C4orf33 | SNV | Missense_Mutation | novel | c.440A>G | p.Glu147Gly | p.E147G | Q8N1A6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4orf33 | SNV | Missense_Mutation | c.346G>T | p.Gly116Cys | p.G116C | Q8N1A6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BS-A0TE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
C4orf33 | SNV | Missense_Mutation | novel | c.411N>G | p.Ile137Met | p.I137M | Q8N1A6 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4orf33 | SNV | Missense_Mutation | c.367N>T | p.Ser123Cys | p.S123C | Q8N1A6 | protein_coding | tolerated(0.1) | benign(0.01) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
C4orf33 | SNV | Missense_Mutation | novel | c.290N>T | p.Trp97Leu | p.W97L | Q8N1A6 | protein_coding | tolerated(0.16) | benign(0.173) | TCGA-85-A53L-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C4orf33 | SNV | Missense_Mutation | c.178N>A | p.Glu60Lys | p.E60K | Q8N1A6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CV-6952-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C4orf33 | SNV | Missense_Mutation | novel | c.96N>A | p.Met32Ile | p.M32I | Q8N1A6 | protein_coding | tolerated(0.16) | benign(0.038) | TCGA-CV-7095-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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