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Gene: C2orf76 |
Gene summary for C2ORF76 |
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Gene information | Species | Human | Gene symbol | C2orf76 | Gene ID | 130355 |
Gene name | chromosome 2 open reading frame 76 | |
Gene Alias | AIM29 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q3KRA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
130355 | C2orf76 | P24T-E | Human | Esophagus | ESCC | 6.89e-08 | 1.50e-01 | 0.1287 |
130355 | C2orf76 | P26T-E | Human | Esophagus | ESCC | 1.16e-14 | 3.09e-01 | 0.1276 |
130355 | C2orf76 | P27T-E | Human | Esophagus | ESCC | 1.09e-08 | 1.99e-01 | 0.1055 |
130355 | C2orf76 | P28T-E | Human | Esophagus | ESCC | 8.35e-13 | 2.32e-01 | 0.1149 |
130355 | C2orf76 | P30T-E | Human | Esophagus | ESCC | 8.57e-20 | 4.19e-01 | 0.137 |
130355 | C2orf76 | P31T-E | Human | Esophagus | ESCC | 3.09e-04 | 8.57e-02 | 0.1251 |
130355 | C2orf76 | P32T-E | Human | Esophagus | ESCC | 6.78e-11 | 2.30e-01 | 0.1666 |
130355 | C2orf76 | P36T-E | Human | Esophagus | ESCC | 5.56e-04 | 6.45e-02 | 0.1187 |
130355 | C2orf76 | P37T-E | Human | Esophagus | ESCC | 1.32e-10 | 1.35e-01 | 0.1371 |
130355 | C2orf76 | P38T-E | Human | Esophagus | ESCC | 2.35e-07 | 2.27e-01 | 0.127 |
130355 | C2orf76 | P39T-E | Human | Esophagus | ESCC | 1.31e-10 | 2.23e-01 | 0.0894 |
130355 | C2orf76 | P40T-E | Human | Esophagus | ESCC | 1.79e-04 | 7.78e-02 | 0.109 |
130355 | C2orf76 | P42T-E | Human | Esophagus | ESCC | 2.42e-10 | 1.71e-01 | 0.1175 |
130355 | C2orf76 | P44T-E | Human | Esophagus | ESCC | 6.58e-09 | 1.60e-01 | 0.1096 |
130355 | C2orf76 | P47T-E | Human | Esophagus | ESCC | 4.20e-04 | 5.89e-02 | 0.1067 |
130355 | C2orf76 | P48T-E | Human | Esophagus | ESCC | 4.95e-09 | 1.54e-01 | 0.0959 |
130355 | C2orf76 | P49T-E | Human | Esophagus | ESCC | 2.04e-02 | 4.82e-01 | 0.1768 |
130355 | C2orf76 | P52T-E | Human | Esophagus | ESCC | 1.72e-12 | 2.76e-01 | 0.1555 |
130355 | C2orf76 | P54T-E | Human | Esophagus | ESCC | 1.10e-09 | 1.92e-01 | 0.0975 |
130355 | C2orf76 | P56T-E | Human | Esophagus | ESCC | 8.45e-06 | 7.66e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C2orf76 | SNV | Missense_Mutation | c.313N>G | p.Thr105Ala | p.T105A | Q3KRA6 | protein_coding | deleterious(0.01) | possibly_damaging(0.873) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
C2orf76 | insertion | Frame_Shift_Ins | novel | c.44_45insAGACCCACCTA | p.Phe16AspfsTer13 | p.F16Dfs*13 | Q3KRA6 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
C2orf76 | SNV | Missense_Mutation | rs200764717 | c.118N>A | p.Val40Ile | p.V40I | Q3KRA6 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
C2orf76 | SNV | Missense_Mutation | rs780592227 | c.56N>A | p.Arg19His | p.R19H | Q3KRA6 | protein_coding | tolerated(0.06) | possibly_damaging(0.618) | TCGA-CA-6716-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR |
C2orf76 | SNV | Missense_Mutation | rs374956671 | c.256G>A | p.Glu86Lys | p.E86K | Q3KRA6 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
C2orf76 | SNV | Missense_Mutation | c.99A>C | p.Gln33His | p.Q33H | Q3KRA6 | protein_coding | tolerated(0.08) | probably_damaging(0.922) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C2orf76 | SNV | Missense_Mutation | c.281N>T | p.Ser94Ile | p.S94I | Q3KRA6 | protein_coding | tolerated(0.14) | benign(0.023) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
C2orf76 | SNV | Missense_Mutation | rs771993808 | c.32N>A | p.Arg11His | p.R11H | Q3KRA6 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
C2orf76 | SNV | Missense_Mutation | rs780592227 | c.56N>A | p.Arg19His | p.R19H | Q3KRA6 | protein_coding | tolerated(0.06) | possibly_damaging(0.618) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C2orf76 | SNV | Missense_Mutation | rs374956671 | c.256N>A | p.Glu86Lys | p.E86K | Q3KRA6 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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