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Gene: C2orf74 |
Gene summary for C2ORF74 |
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Gene information | Species | Human | Gene symbol | C2orf74 | Gene ID | 339804 |
Gene name | chromosome 2 open reading frame 74 | |
Gene Alias | C2orf74 | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A8MZ97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339804 | C2orf74 | P37T-E | Human | Esophagus | ESCC | 3.37e-15 | 2.84e-01 | 0.1371 |
339804 | C2orf74 | P40T-E | Human | Esophagus | ESCC | 1.70e-03 | 1.52e-01 | 0.109 |
339804 | C2orf74 | P42T-E | Human | Esophagus | ESCC | 1.83e-15 | 3.86e-01 | 0.1175 |
339804 | C2orf74 | P44T-E | Human | Esophagus | ESCC | 1.25e-08 | 2.48e-01 | 0.1096 |
339804 | C2orf74 | P48T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.21e-01 | 0.0959 |
339804 | C2orf74 | P49T-E | Human | Esophagus | ESCC | 1.97e-16 | 1.04e+00 | 0.1768 |
339804 | C2orf74 | P57T-E | Human | Esophagus | ESCC | 3.19e-23 | 4.51e-01 | 0.0926 |
339804 | C2orf74 | P61T-E | Human | Esophagus | ESCC | 1.59e-04 | 1.21e-01 | 0.099 |
339804 | C2orf74 | P62T-E | Human | Esophagus | ESCC | 8.71e-46 | 6.66e-01 | 0.1302 |
339804 | C2orf74 | P74T-E | Human | Esophagus | ESCC | 4.95e-14 | 3.75e-01 | 0.1479 |
339804 | C2orf74 | P76T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.58e-01 | 0.1207 |
339804 | C2orf74 | P82T-E | Human | Esophagus | ESCC | 2.98e-07 | 3.53e-01 | 0.1072 |
339804 | C2orf74 | P83T-E | Human | Esophagus | ESCC | 2.90e-21 | 5.44e-01 | 0.1738 |
339804 | C2orf74 | P89T-E | Human | Esophagus | ESCC | 1.77e-26 | 1.00e+00 | 0.1752 |
339804 | C2orf74 | P91T-E | Human | Esophagus | ESCC | 6.28e-18 | 8.93e-01 | 0.1828 |
339804 | C2orf74 | P107T-E | Human | Esophagus | ESCC | 1.03e-17 | 3.64e-01 | 0.171 |
339804 | C2orf74 | P127T-E | Human | Esophagus | ESCC | 1.65e-03 | 1.03e-01 | 0.0826 |
339804 | C2orf74 | P128T-E | Human | Esophagus | ESCC | 6.62e-11 | 2.91e-01 | 0.1241 |
339804 | C2orf74 | HCC1_Meng | Human | Liver | HCC | 2.41e-50 | 7.58e-02 | 0.0246 |
339804 | C2orf74 | HCC2_Meng | Human | Liver | HCC | 9.99e-11 | 4.09e-02 | 0.0107 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C2orf74 | insertion | In_Frame_Ins | novel | c.255_256insGTGACATTTTCTAGGGAGGTAATTGTTGTGGATCTTGGGAAT | p.Val86_Asn99dup | p.V86_N99dup | protein_coding | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
C2orf74 | SNV | Missense_Mutation | novel | c.141N>T | p.Glu47Asp | p.E47D | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.57N>C | p.Gln19His | p.Q19H | protein_coding | tolerated(0.08) | benign(0.077) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.242N>T | p.Arg81Ile | p.R81I | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
C2orf74 | SNV | Missense_Mutation | rs574904888 | c.314N>A | p.Arg105Gln | p.R105Q | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
C2orf74 | SNV | Missense_Mutation | rs771315443 | c.326N>A | p.Arg109Gln | p.R109Q | protein_coding | tolerated(0.19) | benign(0.06) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.281N>G | p.Val94Gly | p.V94G | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.235N>A | p.Gln79Lys | p.Q79K | protein_coding | deleterious(0.04) | benign(0.167) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.174N>T | p.Glu58Asp | p.E58D | protein_coding | tolerated(0.6) | benign(0.328) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
C2orf74 | SNV | Missense_Mutation | rs574904888 | c.314G>A | p.Arg105Gln | p.R105Q | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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