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Gene: C20orf96 |
Gene summary for C20ORF96 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C20orf96 | Gene ID | 140680 |
| Gene name | chromosome 20 open reading frame 96 | |
| Gene Alias | dJ1103G7.2 | |
| Cytomap | 20p13 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | B7ZML9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 140680 | C20orf96 | P32T-E | Human | Esophagus | ESCC | 2.63e-13 | 9.82e-02 | 0.1666 |
| 140680 | C20orf96 | P36T-E | Human | Esophagus | ESCC | 1.32e-05 | 1.18e-01 | 0.1187 |
| 140680 | C20orf96 | P37T-E | Human | Esophagus | ESCC | 6.57e-17 | 2.59e-01 | 0.1371 |
| 140680 | C20orf96 | P44T-E | Human | Esophagus | ESCC | 2.00e-03 | 1.09e-01 | 0.1096 |
| 140680 | C20orf96 | P48T-E | Human | Esophagus | ESCC | 1.49e-03 | 6.11e-02 | 0.0959 |
| 140680 | C20orf96 | P52T-E | Human | Esophagus | ESCC | 2.95e-02 | 8.61e-02 | 0.1555 |
| 140680 | C20orf96 | P54T-E | Human | Esophagus | ESCC | 1.77e-11 | 1.96e-01 | 0.0975 |
| 140680 | C20orf96 | P56T-E | Human | Esophagus | ESCC | 3.16e-07 | 6.51e-01 | 0.1613 |
| 140680 | C20orf96 | P57T-E | Human | Esophagus | ESCC | 3.86e-10 | 2.08e-01 | 0.0926 |
| 140680 | C20orf96 | P61T-E | Human | Esophagus | ESCC | 1.21e-07 | 1.18e-01 | 0.099 |
| 140680 | C20orf96 | P62T-E | Human | Esophagus | ESCC | 2.75e-06 | 1.30e-01 | 0.1302 |
| 140680 | C20orf96 | P65T-E | Human | Esophagus | ESCC | 5.62e-10 | 2.06e-01 | 0.0978 |
| 140680 | C20orf96 | P74T-E | Human | Esophagus | ESCC | 3.98e-09 | 2.37e-01 | 0.1479 |
| 140680 | C20orf96 | P75T-E | Human | Esophagus | ESCC | 1.15e-05 | 7.66e-02 | 0.1125 |
| 140680 | C20orf96 | P76T-E | Human | Esophagus | ESCC | 2.34e-11 | 2.92e-01 | 0.1207 |
| 140680 | C20orf96 | P79T-E | Human | Esophagus | ESCC | 6.59e-13 | 2.16e-01 | 0.1154 |
| 140680 | C20orf96 | P80T-E | Human | Esophagus | ESCC | 5.15e-16 | 3.88e-01 | 0.155 |
| 140680 | C20orf96 | P82T-E | Human | Esophagus | ESCC | 2.48e-08 | 3.66e-01 | 0.1072 |
| 140680 | C20orf96 | P83T-E | Human | Esophagus | ESCC | 2.73e-23 | 6.60e-01 | 0.1738 |
| 140680 | C20orf96 | P89T-E | Human | Esophagus | ESCC | 3.00e-03 | 2.27e-01 | 0.1752 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| C20orf96 | SNV | Missense_Mutation | novel | c.234N>C | p.Lys78Asn | p.K78N | Q9NUD7 | protein_coding | deleterious(0.01) | possibly_damaging(0.447) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
| C20orf96 | SNV | Missense_Mutation | c.1021N>T | p.Arg341Trp | p.R341W | Q9NUD7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| C20orf96 | insertion | Frame_Shift_Ins | novel | c.829_830insTGACCCATTTACAACCATCACCAAACATCACCTATTCAGCCATTAAC | p.Thr277MetfsTer36 | p.T277Mfs*36 | Q9NUD7 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
| C20orf96 | insertion | Nonsense_Mutation | novel | c.73_74insCCCAGTGAGGAAAAGGGAATAAATC | p.Tyr25SerfsTer3 | p.Y25Sfs*3 | Q9NUD7 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| C20orf96 | insertion | In_Frame_Ins | novel | c.71_72insCCTGCTGGACACTGCCAACAC | p.Asp24_Tyr25insLeuLeuAspThrAlaAsnThr | p.D24_Y25insLLDTANT | Q9NUD7 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| C20orf96 | SNV | Missense_Mutation | novel | c.321N>A | p.Ser107Arg | p.S107R | Q9NUD7 | protein_coding | deleterious(0.01) | benign(0.031) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
| C20orf96 | SNV | Missense_Mutation | c.792N>T | p.Lys264Asn | p.K264N | Q9NUD7 | protein_coding | tolerated(0.34) | benign(0.012) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| C20orf96 | SNV | Missense_Mutation | novel | c.148N>A | p.His50Asn | p.H50N | Q9NUD7 | protein_coding | tolerated(0.43) | benign(0) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| C20orf96 | insertion | Frame_Shift_Ins | novel | c.319_320insCGGAGGGAGGGAGG | p.Ser107ThrfsTer28 | p.S107Tfs*28 | Q9NUD7 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
| C20orf96 | SNV | Missense_Mutation | novel | c.10N>A | p.Val4Ile | p.V4I | Q9NUD7 | protein_coding | tolerated(0.29) | benign(0.014) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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