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Gene: C1orf21 |
Gene summary for C1ORF21 |
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Gene information | Species | Human | Gene symbol | C1orf21 | Gene ID | 81563 |
Gene name | chromosome 1 open reading frame 21 | |
Gene Alias | PIG13 | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R926 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81563 | C1orf21 | brca2 | Human | Breast | Precancer | 3.10e-02 | -1.33e-01 | -0.024 |
81563 | C1orf21 | M5 | Human | Breast | IDC | 2.92e-20 | 1.09e+00 | 0.1598 |
81563 | C1orf21 | NCCBC14 | Human | Breast | DCIS | 4.35e-06 | 3.51e-01 | 0.2021 |
81563 | C1orf21 | NCCBC5 | Human | Breast | DCIS | 5.87e-04 | -1.73e-01 | 0.2046 |
81563 | C1orf21 | P1 | Human | Breast | IDC | 1.69e-05 | -3.14e-02 | 0.1527 |
81563 | C1orf21 | P2 | Human | Breast | IDC | 1.45e-05 | -2.76e-01 | 0.21 |
81563 | C1orf21 | DCIS2 | Human | Breast | DCIS | 3.45e-39 | 2.06e-01 | 0.0085 |
81563 | C1orf21 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.30e-24 | -8.43e-01 | 0.0155 |
81563 | C1orf21 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-25 | 8.02e-01 | -0.1954 |
81563 | C1orf21 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.42e-03 | 9.91e-01 | -0.2602 |
81563 | C1orf21 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.13e-06 | -6.02e-01 | -0.1207 |
81563 | C1orf21 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.86e-17 | -7.78e-01 | 0.096 |
81563 | C1orf21 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.58e-06 | -7.13e-01 | 0.0338 |
81563 | C1orf21 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.59e-35 | -8.78e-01 | 0.0674 |
81563 | C1orf21 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.14e-03 | -9.61e-01 | 0.0397 |
81563 | C1orf21 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.25e-23 | -6.62e-01 | 0.294 |
81563 | C1orf21 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.34e-03 | -4.72e-01 | 0.3859 |
81563 | C1orf21 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.83e-12 | -9.29e-01 | 0.2585 |
81563 | C1orf21 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.67e-37 | -8.70e-01 | 0.3005 |
81563 | C1orf21 | F007 | Human | Colorectum | FAP | 4.71e-15 | -8.32e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf21 | SNV | Missense_Mutation | c.349N>C | p.Glu117Gln | p.E117Q | Q9H246 | protein_coding | tolerated(0.06) | possibly_damaging(0.607) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
C1orf21 | SNV | Missense_Mutation | c.310N>T | p.Asp104Tyr | p.D104Y | Q9H246 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-C5-A2LT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
C1orf21 | SNV | Missense_Mutation | c.14N>T | p.Ser5Phe | p.S5F | Q9H246 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C1orf21 | SNV | Missense_Mutation | c.242G>A | p.Gly81Glu | p.G81E | Q9H246 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C1orf21 | SNV | Missense_Mutation | c.314A>G | p.Glu105Gly | p.E105G | Q9H246 | protein_coding | deleterious(0) | benign(0.025) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
C1orf21 | SNV | Missense_Mutation | c.28N>A | p.Ala10Thr | p.A10T | Q9H246 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C1orf21 | SNV | Missense_Mutation | novel | c.317A>G | p.Lys106Arg | p.K106R | Q9H246 | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf21 | SNV | Missense_Mutation | novel | c.200N>T | p.Ala67Val | p.A67V | Q9H246 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
C1orf21 | SNV | Missense_Mutation | c.250N>T | p.His84Tyr | p.H84Y | Q9H246 | protein_coding | tolerated(0.31) | possibly_damaging(0.607) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1orf21 | SNV | Missense_Mutation | c.297N>A | p.Phe99Leu | p.F99L | Q9H246 | protein_coding | deleterious(0.01) | possibly_damaging(0.682) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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