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Gene: C14orf2 |
Gene summary for C14ORF2 |
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Gene information | Species | Human | Gene symbol | C14orf2 | Gene ID | 9556 |
Gene name | ATP synthase membrane subunit j | |
Gene Alias | 6.8PL | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R6N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9556 | C14orf2 | GSM4909303 | Human | Breast | IDC | 9.27e-06 | -3.58e-01 | 0.0438 |
9556 | C14orf2 | GSM4909304 | Human | Breast | IDC | 2.44e-15 | -3.58e-01 | 0.1636 |
9556 | C14orf2 | GSM4909305 | Human | Breast | IDC | 5.28e-15 | -3.58e-01 | 0.0436 |
9556 | C14orf2 | GSM4909306 | Human | Breast | IDC | 2.12e-16 | -3.58e-01 | 0.1564 |
9556 | C14orf2 | GSM4909307 | Human | Breast | IDC | 1.23e-14 | -3.58e-01 | 0.1569 |
9556 | C14orf2 | GSM4909308 | Human | Breast | IDC | 4.86e-19 | -3.58e-01 | 0.158 |
9556 | C14orf2 | GSM4909309 | Human | Breast | IDC | 4.17e-19 | -3.58e-01 | 0.0483 |
9556 | C14orf2 | GSM4909311 | Human | Breast | IDC | 1.23e-14 | -3.58e-01 | 0.1534 |
9556 | C14orf2 | GSM4909312 | Human | Breast | IDC | 5.48e-15 | -3.58e-01 | 0.1552 |
9556 | C14orf2 | GSM4909313 | Human | Breast | IDC | 9.00e-19 | -3.58e-01 | 0.0391 |
9556 | C14orf2 | GSM4909315 | Human | Breast | IDC | 4.12e-17 | -3.58e-01 | 0.21 |
9556 | C14orf2 | GSM4909316 | Human | Breast | IDC | 5.86e-06 | -3.58e-01 | 0.21 |
9556 | C14orf2 | GSM4909317 | Human | Breast | IDC | 1.43e-18 | -3.58e-01 | 0.1355 |
9556 | C14orf2 | GSM4909318 | Human | Breast | IDC | 1.70e-02 | -3.58e-01 | 0.2031 |
9556 | C14orf2 | GSM4909319 | Human | Breast | IDC | 9.36e-17 | -3.58e-01 | 0.1563 |
9556 | C14orf2 | GSM4909320 | Human | Breast | IDC | 4.94e-07 | -3.58e-01 | 0.1575 |
9556 | C14orf2 | GSM4909321 | Human | Breast | IDC | 1.08e-15 | -3.58e-01 | 0.1559 |
9556 | C14orf2 | ctrl6 | Human | Breast | Precancer | 8.28e-09 | -3.58e-01 | -0.0061 |
9556 | C14orf2 | brca1 | Human | Breast | Precancer | 2.09e-02 | 2.52e-01 | -0.0338 |
9556 | C14orf2 | brca2 | Human | Breast | Precancer | 2.23e-58 | 8.71e-01 | -0.024 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf2 | SNV | Missense_Mutation | rs749080256 | c.154N>A | p.Val52Ile | p.V52I | P56378 | protein_coding | tolerated(0.38) | benign(0.107) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
C14orf2 | SNV | Missense_Mutation | c.182N>T | p.Arg61Ile | p.R61I | P56378 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf2 | SNV | Missense_Mutation | c.42N>G | p.Phe14Leu | p.F14L | P56378 | protein_coding | tolerated_low_confidence(0.73) | benign(0) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
C14orf2 | SNV | Missense_Mutation | novel | c.136G>T | p.Gly46Trp | p.G46W | P56378 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C14orf2 | SNV | Missense_Mutation | novel | c.101N>C | p.Tyr34Ser | p.Y34S | P56378 | protein_coding | tolerated(0.08) | possibly_damaging(0.747) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C14orf2 | SNV | Missense_Mutation | novel | c.83N>G | p.Ile28Ser | p.I28S | P56378 | protein_coding | tolerated(0.25) | benign(0.373) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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