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Gene: C14orf119 |
Gene summary for C14ORF119 |
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Gene information | Species | Human | Gene symbol | C14orf119 | Gene ID | 55017 |
Gene name | chromosome 14 open reading frame 119 | |
Gene Alias | C14orf119 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NWQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55017 | C14orf119 | P16T-E | Human | Esophagus | ESCC | 2.83e-32 | 5.75e-01 | 0.1153 |
55017 | C14orf119 | P17T-E | Human | Esophagus | ESCC | 1.23e-14 | 8.05e-01 | 0.1278 |
55017 | C14orf119 | P19T-E | Human | Esophagus | ESCC | 1.54e-10 | 7.00e-01 | 0.1662 |
55017 | C14orf119 | P20T-E | Human | Esophagus | ESCC | 1.30e-21 | 4.61e-01 | 0.1124 |
55017 | C14orf119 | P21T-E | Human | Esophagus | ESCC | 5.68e-48 | 9.87e-01 | 0.1617 |
55017 | C14orf119 | P22T-E | Human | Esophagus | ESCC | 1.29e-41 | 8.64e-01 | 0.1236 |
55017 | C14orf119 | P23T-E | Human | Esophagus | ESCC | 2.54e-42 | 1.23e+00 | 0.108 |
55017 | C14orf119 | P24T-E | Human | Esophagus | ESCC | 1.85e-33 | 7.65e-01 | 0.1287 |
55017 | C14orf119 | P26T-E | Human | Esophagus | ESCC | 3.22e-54 | 1.09e+00 | 0.1276 |
55017 | C14orf119 | P27T-E | Human | Esophagus | ESCC | 1.31e-40 | 9.10e-01 | 0.1055 |
55017 | C14orf119 | P28T-E | Human | Esophagus | ESCC | 8.67e-57 | 1.17e+00 | 0.1149 |
55017 | C14orf119 | P30T-E | Human | Esophagus | ESCC | 5.53e-38 | 1.25e+00 | 0.137 |
55017 | C14orf119 | P31T-E | Human | Esophagus | ESCC | 1.37e-58 | 1.12e+00 | 0.1251 |
55017 | C14orf119 | P32T-E | Human | Esophagus | ESCC | 1.22e-33 | 6.87e-01 | 0.1666 |
55017 | C14orf119 | P36T-E | Human | Esophagus | ESCC | 1.04e-17 | 5.36e-01 | 0.1187 |
55017 | C14orf119 | P37T-E | Human | Esophagus | ESCC | 1.19e-33 | 9.09e-01 | 0.1371 |
55017 | C14orf119 | P38T-E | Human | Esophagus | ESCC | 3.61e-15 | 6.54e-01 | 0.127 |
55017 | C14orf119 | P39T-E | Human | Esophagus | ESCC | 1.02e-30 | 5.83e-01 | 0.0894 |
55017 | C14orf119 | P40T-E | Human | Esophagus | ESCC | 6.36e-14 | 5.90e-01 | 0.109 |
55017 | C14orf119 | P42T-E | Human | Esophagus | ESCC | 1.05e-26 | 7.50e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf119 | SNV | Missense_Mutation | c.44N>A | p.Ser15Tyr | p.S15Y | Q9NWQ9 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.452) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
C14orf119 | SNV | Missense_Mutation | novel | c.114N>C | p.Glu38Asp | p.E38D | Q9NWQ9 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
C14orf119 | SNV | Missense_Mutation | novel | c.277G>A | p.Glu93Lys | p.E93K | Q9NWQ9 | protein_coding | tolerated(0.11) | possibly_damaging(0.572) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
C14orf119 | SNV | Missense_Mutation | novel | c.184G>A | p.Val62Ile | p.V62I | Q9NWQ9 | protein_coding | tolerated(0.14) | benign(0.146) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C14orf119 | SNV | Missense_Mutation | c.313N>T | p.Gly105Cys | p.G105C | Q9NWQ9 | protein_coding | deleterious(0.02) | probably_damaging(0.939) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C14orf119 | SNV | Missense_Mutation | rs751433100 | c.161G>A | p.Arg54His | p.R54H | Q9NWQ9 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
C14orf119 | SNV | Missense_Mutation | novel | c.26N>C | p.Met9Thr | p.M9T | Q9NWQ9 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C14orf119 | SNV | Missense_Mutation | novel | c.251N>A | p.Gly84Glu | p.G84E | Q9NWQ9 | protein_coding | tolerated_low_confidence(0.08) | benign(0.013) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
C14orf119 | SNV | Missense_Mutation | rs751433100 | c.161N>A | p.Arg54His | p.R54H | Q9NWQ9 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
C14orf119 | SNV | Missense_Mutation | novel | c.322G>A | p.Glu108Lys | p.E108K | Q9NWQ9 | protein_coding | deleterious(0.01) | possibly_damaging(0.857) | TCGA-56-7221-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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