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Gene: BRI3BP |
Gene summary for BRI3BP |
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Gene information | Species | Human | Gene symbol | BRI3BP | Gene ID | 140707 |
Gene name | BRI3 binding protein | |
Gene Alias | BNAS1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WY22 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140707 | BRI3BP | P16T-E | Human | Esophagus | ESCC | 3.24e-05 | 2.17e-01 | 0.1153 |
140707 | BRI3BP | P17T-E | Human | Esophagus | ESCC | 1.53e-03 | 2.08e-01 | 0.1278 |
140707 | BRI3BP | P20T-E | Human | Esophagus | ESCC | 6.00e-10 | 2.55e-01 | 0.1124 |
140707 | BRI3BP | P21T-E | Human | Esophagus | ESCC | 2.42e-25 | 6.24e-01 | 0.1617 |
140707 | BRI3BP | P22T-E | Human | Esophagus | ESCC | 4.62e-09 | 2.35e-01 | 0.1236 |
140707 | BRI3BP | P23T-E | Human | Esophagus | ESCC | 9.57e-08 | 2.87e-01 | 0.108 |
140707 | BRI3BP | P24T-E | Human | Esophagus | ESCC | 1.42e-05 | 1.90e-01 | 0.1287 |
140707 | BRI3BP | P26T-E | Human | Esophagus | ESCC | 3.99e-16 | 2.94e-01 | 0.1276 |
140707 | BRI3BP | P27T-E | Human | Esophagus | ESCC | 5.97e-13 | 3.20e-01 | 0.1055 |
140707 | BRI3BP | P28T-E | Human | Esophagus | ESCC | 9.81e-26 | 5.92e-01 | 0.1149 |
140707 | BRI3BP | P30T-E | Human | Esophagus | ESCC | 6.34e-09 | 4.42e-01 | 0.137 |
140707 | BRI3BP | P31T-E | Human | Esophagus | ESCC | 2.84e-10 | 2.30e-01 | 0.1251 |
140707 | BRI3BP | P32T-E | Human | Esophagus | ESCC | 4.50e-11 | 2.21e-01 | 0.1666 |
140707 | BRI3BP | P36T-E | Human | Esophagus | ESCC | 3.19e-05 | 3.08e-01 | 0.1187 |
140707 | BRI3BP | P37T-E | Human | Esophagus | ESCC | 1.80e-12 | 3.35e-01 | 0.1371 |
140707 | BRI3BP | P39T-E | Human | Esophagus | ESCC | 9.34e-17 | 3.42e-01 | 0.0894 |
140707 | BRI3BP | P40T-E | Human | Esophagus | ESCC | 1.61e-02 | 1.53e-01 | 0.109 |
140707 | BRI3BP | P42T-E | Human | Esophagus | ESCC | 3.63e-05 | 2.52e-01 | 0.1175 |
140707 | BRI3BP | P44T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.67e-01 | 0.1096 |
140707 | BRI3BP | P47T-E | Human | Esophagus | ESCC | 3.63e-15 | 1.28e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRI3BP | SNV | Missense_Mutation | c.394N>A | p.Val132Ile | p.V132I | Q8WY22 | protein_coding | tolerated(0.25) | benign(0.041) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
BRI3BP | SNV | Missense_Mutation | c.388N>A | p.Gly130Ser | p.G130S | Q8WY22 | protein_coding | deleterious(0.03) | possibly_damaging(0.871) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BRI3BP | SNV | Missense_Mutation | novel | c.410N>T | p.Trp137Leu | p.W137L | Q8WY22 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BRI3BP | SNV | Missense_Mutation | c.316N>A | p.Val106Ile | p.V106I | Q8WY22 | protein_coding | deleterious(0.05) | benign(0.123) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
BRI3BP | SNV | Missense_Mutation | c.658N>A | p.Val220Met | p.V220M | Q8WY22 | protein_coding | tolerated_low_confidence(0.06) | benign(0.07) | TCGA-BS-A0TC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BRI3BP | SNV | Missense_Mutation | rs779314883 | c.373N>A | p.Ala125Thr | p.A125T | Q8WY22 | protein_coding | tolerated(0.12) | possibly_damaging(0.69) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BRI3BP | SNV | Missense_Mutation | rs752859936 | c.595N>C | p.Gly199Arg | p.G199R | Q8WY22 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
BRI3BP | SNV | Missense_Mutation | c.638G>A | p.Ser213Asn | p.S213N | Q8WY22 | protein_coding | tolerated_low_confidence(0.09) | benign(0.242) | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD | |
BRI3BP | SNV | Missense_Mutation | c.316N>A | p.Val106Ile | p.V106I | Q8WY22 | protein_coding | deleterious(0.05) | benign(0.123) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BRI3BP | SNV | Missense_Mutation | novel | c.538G>A | p.Glu180Lys | p.E180K | Q8WY22 | protein_coding | deleterious(0.02) | possibly_damaging(0.749) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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