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Gene: BORCS8 |
Gene summary for BORCS8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | BORCS8 | Gene ID | 729991 |
| Gene name | BLOC-1 related complex subunit 8 | |
| Gene Alias | MEF2BNB | |
| Cytomap | 19p13.11 | |
| Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q96FH0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 729991 | BORCS8 | P21T-E | Human | Esophagus | ESCC | 1.13e-14 | 3.02e-01 | 0.1617 |
| 729991 | BORCS8 | P22T-E | Human | Esophagus | ESCC | 3.30e-06 | 1.53e-01 | 0.1236 |
| 729991 | BORCS8 | P23T-E | Human | Esophagus | ESCC | 1.97e-13 | 3.62e-01 | 0.108 |
| 729991 | BORCS8 | P24T-E | Human | Esophagus | ESCC | 3.32e-17 | 2.00e-01 | 0.1287 |
| 729991 | BORCS8 | P26T-E | Human | Esophagus | ESCC | 4.11e-15 | 1.97e-01 | 0.1276 |
| 729991 | BORCS8 | P27T-E | Human | Esophagus | ESCC | 5.15e-08 | 1.94e-01 | 0.1055 |
| 729991 | BORCS8 | P28T-E | Human | Esophagus | ESCC | 1.42e-10 | 2.70e-01 | 0.1149 |
| 729991 | BORCS8 | P30T-E | Human | Esophagus | ESCC | 9.72e-05 | 1.29e-01 | 0.137 |
| 729991 | BORCS8 | P31T-E | Human | Esophagus | ESCC | 2.32e-08 | 1.97e-01 | 0.1251 |
| 729991 | BORCS8 | P32T-E | Human | Esophagus | ESCC | 2.49e-16 | 3.33e-01 | 0.1666 |
| 729991 | BORCS8 | P36T-E | Human | Esophagus | ESCC | 7.33e-03 | 7.53e-02 | 0.1187 |
| 729991 | BORCS8 | P37T-E | Human | Esophagus | ESCC | 3.42e-08 | 1.62e-01 | 0.1371 |
| 729991 | BORCS8 | P39T-E | Human | Esophagus | ESCC | 4.33e-06 | 1.46e-01 | 0.0894 |
| 729991 | BORCS8 | P40T-E | Human | Esophagus | ESCC | 1.21e-03 | 1.40e-01 | 0.109 |
| 729991 | BORCS8 | P42T-E | Human | Esophagus | ESCC | 9.28e-09 | 2.02e-01 | 0.1175 |
| 729991 | BORCS8 | P44T-E | Human | Esophagus | ESCC | 2.91e-02 | 6.13e-02 | 0.1096 |
| 729991 | BORCS8 | P47T-E | Human | Esophagus | ESCC | 1.55e-05 | 6.55e-02 | 0.1067 |
| 729991 | BORCS8 | P48T-E | Human | Esophagus | ESCC | 5.96e-03 | 1.05e-01 | 0.0959 |
| 729991 | BORCS8 | P49T-E | Human | Esophagus | ESCC | 1.60e-06 | 5.13e-01 | 0.1768 |
| 729991 | BORCS8 | P52T-E | Human | Esophagus | ESCC | 5.81e-12 | 3.05e-01 | 0.1555 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| BORCS8 | SNV | Missense_Mutation | novel | c.35N>G | p.Lys12Arg | p.K12R | Q96FH0 | protein_coding | tolerated(0.35) | benign(0.017) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| BORCS8 | SNV | Missense_Mutation | rs566625799 | c.259N>A | p.Val87Met | p.V87M | Q96FH0 | protein_coding | deleterious(0) | possibly_damaging(0.542) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| BORCS8 | SNV | Missense_Mutation | novel | c.22N>A | p.Leu8Ile | p.L8I | Q96FH0 | protein_coding | tolerated(0.39) | benign(0.031) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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