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Gene: BEX2 |
Gene summary for BEX2 |
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Gene information | Species | Human | Gene symbol | BEX2 | Gene ID | 84707 |
Gene name | brain expressed X-linked 2 | |
Gene Alias | BEX1 | |
Cytomap | Xq22.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q9BXY8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84707 | BEX2 | P30T-E | Human | Esophagus | ESCC | 7.65e-12 | 8.93e-01 | 0.137 |
84707 | BEX2 | P32T-E | Human | Esophagus | ESCC | 4.01e-21 | 7.29e-01 | 0.1666 |
84707 | BEX2 | P37T-E | Human | Esophagus | ESCC | 1.27e-11 | 2.67e-01 | 0.1371 |
84707 | BEX2 | P38T-E | Human | Esophagus | ESCC | 3.99e-02 | -7.36e-02 | 0.127 |
84707 | BEX2 | P39T-E | Human | Esophagus | ESCC | 4.37e-02 | 1.81e-01 | 0.0894 |
84707 | BEX2 | P40T-E | Human | Esophagus | ESCC | 1.89e-05 | 3.74e-01 | 0.109 |
84707 | BEX2 | P47T-E | Human | Esophagus | ESCC | 1.24e-14 | 5.66e-01 | 0.1067 |
84707 | BEX2 | P48T-E | Human | Esophagus | ESCC | 1.87e-19 | 6.00e-01 | 0.0959 |
84707 | BEX2 | P49T-E | Human | Esophagus | ESCC | 3.10e-02 | 6.16e-01 | 0.1768 |
84707 | BEX2 | P52T-E | Human | Esophagus | ESCC | 3.42e-05 | 4.42e-01 | 0.1555 |
84707 | BEX2 | P56T-E | Human | Esophagus | ESCC | 5.38e-08 | 1.85e+00 | 0.1613 |
84707 | BEX2 | P57T-E | Human | Esophagus | ESCC | 1.81e-16 | 4.48e-01 | 0.0926 |
84707 | BEX2 | P61T-E | Human | Esophagus | ESCC | 6.80e-43 | 1.66e+00 | 0.099 |
84707 | BEX2 | P62T-E | Human | Esophagus | ESCC | 2.90e-25 | 6.29e-01 | 0.1302 |
84707 | BEX2 | P65T-E | Human | Esophagus | ESCC | 6.14e-52 | 1.52e+00 | 0.0978 |
84707 | BEX2 | P74T-E | Human | Esophagus | ESCC | 4.54e-27 | 1.08e+00 | 0.1479 |
84707 | BEX2 | P75T-E | Human | Esophagus | ESCC | 7.34e-11 | 1.51e-01 | 0.1125 |
84707 | BEX2 | P76T-E | Human | Esophagus | ESCC | 3.91e-39 | 7.04e-01 | 0.1207 |
84707 | BEX2 | P79T-E | Human | Esophagus | ESCC | 3.75e-52 | 1.25e+00 | 0.1154 |
84707 | BEX2 | P80T-E | Human | Esophagus | ESCC | 4.11e-14 | 7.69e-01 | 0.155 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BEX2 | SNV | Missense_Mutation | c.356N>A | p.Arg119Lys | p.R119K | Q9BXY8 | protein_coding | tolerated(0.17) | benign(0.026) | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
BEX2 | SNV | Missense_Mutation | c.124N>C | p.Asn42His | p.N42H | Q9BXY8 | protein_coding | deleterious(0) | possibly_damaging(0.66) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
BEX2 | insertion | Frame_Shift_Ins | novel | c.171_172insACGGGAAGACAATTGGGGTTAAGTGTCCCAGCAGAACTAGG | p.Glu58ThrfsTer30 | p.E58Tfs*30 | Q9BXY8 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BEX2 | SNV | Missense_Mutation | novel | c.130N>T | p.Leu44Phe | p.L44F | Q9BXY8 | protein_coding | tolerated(0.08) | possibly_damaging(0.525) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BEX2 | SNV | Missense_Mutation | novel | c.395N>T | p.Arg132Met | p.R132M | Q9BXY8 | protein_coding | deleterious(0) | possibly_damaging(0.799) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BEX2 | SNV | Missense_Mutation | novel | c.55N>A | p.Glu19Lys | p.E19K | Q9BXY8 | protein_coding | tolerated_low_confidence(0.31) | benign(0.007) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
BEX2 | SNV | Missense_Mutation | c.215C>A | p.Pro72His | p.P72H | Q9BXY8 | protein_coding | tolerated(0.1) | benign(0.031) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BEX2 | SNV | Missense_Mutation | novel | c.69G>T | p.Glu23Asp | p.E23D | Q9BXY8 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BEX2 | SNV | Missense_Mutation | c.184G>T | p.Val62Phe | p.V62F | Q9BXY8 | protein_coding | tolerated(0.15) | benign(0.027) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
BEX2 | SNV | Missense_Mutation | novel | c.97A>T | p.Met33Leu | p.M33L | Q9BXY8 | protein_coding | deleterious(0.04) | possibly_damaging(0.743) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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