Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: BBOX1-AS1

Gene summary for BBOX1-AS1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

BBOX1-AS1

Gene ID

103695435

Gene nameBBOX1 antisense RNA 1
Gene AliasBBOX1-AS1
Cytomap11p14.2-p14.1
Gene TypencRNA
GO ID

NA

UniProtAcc

NA


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
103695435BBOX1-AS1P15T-EHumanEsophagusESCC3.15e-163.10e-010.1149
103695435BBOX1-AS1P17T-EHumanEsophagusESCC2.68e-031.74e-010.1278
103695435BBOX1-AS1P20T-EHumanEsophagusESCC1.83e-346.93e-010.1124
103695435BBOX1-AS1P21T-EHumanEsophagusESCC1.59e-306.31e-010.1617
103695435BBOX1-AS1P22T-EHumanEsophagusESCC2.05e-071.57e-010.1236
103695435BBOX1-AS1P23T-EHumanEsophagusESCC7.44e-143.30e-010.108
103695435BBOX1-AS1P24T-EHumanEsophagusESCC2.03e-091.95e-010.1287
103695435BBOX1-AS1P26T-EHumanEsophagusESCC1.25e-265.03e-010.1276
103695435BBOX1-AS1P27T-EHumanEsophagusESCC5.17e-274.89e-010.1055
103695435BBOX1-AS1P28T-EHumanEsophagusESCC7.98e-132.92e-010.1149
103695435BBOX1-AS1P30T-EHumanEsophagusESCC1.16e-215.80e-010.137
103695435BBOX1-AS1P31T-EHumanEsophagusESCC2.55e-315.57e-010.1251
103695435BBOX1-AS1P32T-EHumanEsophagusESCC5.57e-408.01e-010.1666
103695435BBOX1-AS1P36T-EHumanEsophagusESCC6.23e-113.55e-010.1187
103695435BBOX1-AS1P37T-EHumanEsophagusESCC8.30e-153.21e-010.1371
103695435BBOX1-AS1P38T-EHumanEsophagusESCC2.66e-021.30e-010.127
103695435BBOX1-AS1P39T-EHumanEsophagusESCC1.41e-528.89e-010.0894
103695435BBOX1-AS1P40T-EHumanEsophagusESCC2.45e-092.80e-010.109
103695435BBOX1-AS1P42T-EHumanEsophagusESCC2.34e-143.65e-010.1175
103695435BBOX1-AS1P47T-EHumanEsophagusESCC2.86e-203.53e-010.1067
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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