|
Gene: BBOX1-AS1 |
Gene summary for BBOX1-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | BBOX1-AS1 | Gene ID | 103695435 |
Gene name | BBOX1 antisense RNA 1 | |
Gene Alias | BBOX1-AS1 | |
Cytomap | 11p14.2-p14.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
103695435 | BBOX1-AS1 | P15T-E | Human | Esophagus | ESCC | 3.15e-16 | 3.10e-01 | 0.1149 |
103695435 | BBOX1-AS1 | P17T-E | Human | Esophagus | ESCC | 2.68e-03 | 1.74e-01 | 0.1278 |
103695435 | BBOX1-AS1 | P20T-E | Human | Esophagus | ESCC | 1.83e-34 | 6.93e-01 | 0.1124 |
103695435 | BBOX1-AS1 | P21T-E | Human | Esophagus | ESCC | 1.59e-30 | 6.31e-01 | 0.1617 |
103695435 | BBOX1-AS1 | P22T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.57e-01 | 0.1236 |
103695435 | BBOX1-AS1 | P23T-E | Human | Esophagus | ESCC | 7.44e-14 | 3.30e-01 | 0.108 |
103695435 | BBOX1-AS1 | P24T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.95e-01 | 0.1287 |
103695435 | BBOX1-AS1 | P26T-E | Human | Esophagus | ESCC | 1.25e-26 | 5.03e-01 | 0.1276 |
103695435 | BBOX1-AS1 | P27T-E | Human | Esophagus | ESCC | 5.17e-27 | 4.89e-01 | 0.1055 |
103695435 | BBOX1-AS1 | P28T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.92e-01 | 0.1149 |
103695435 | BBOX1-AS1 | P30T-E | Human | Esophagus | ESCC | 1.16e-21 | 5.80e-01 | 0.137 |
103695435 | BBOX1-AS1 | P31T-E | Human | Esophagus | ESCC | 2.55e-31 | 5.57e-01 | 0.1251 |
103695435 | BBOX1-AS1 | P32T-E | Human | Esophagus | ESCC | 5.57e-40 | 8.01e-01 | 0.1666 |
103695435 | BBOX1-AS1 | P36T-E | Human | Esophagus | ESCC | 6.23e-11 | 3.55e-01 | 0.1187 |
103695435 | BBOX1-AS1 | P37T-E | Human | Esophagus | ESCC | 8.30e-15 | 3.21e-01 | 0.1371 |
103695435 | BBOX1-AS1 | P38T-E | Human | Esophagus | ESCC | 2.66e-02 | 1.30e-01 | 0.127 |
103695435 | BBOX1-AS1 | P39T-E | Human | Esophagus | ESCC | 1.41e-52 | 8.89e-01 | 0.0894 |
103695435 | BBOX1-AS1 | P40T-E | Human | Esophagus | ESCC | 2.45e-09 | 2.80e-01 | 0.109 |
103695435 | BBOX1-AS1 | P42T-E | Human | Esophagus | ESCC | 2.34e-14 | 3.65e-01 | 0.1175 |
103695435 | BBOX1-AS1 | P47T-E | Human | Esophagus | ESCC | 2.86e-20 | 3.53e-01 | 0.1067 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |