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Gene: BAZ2B |
Gene summary for BAZ2B |
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Gene information | Species | Human | Gene symbol | BAZ2B | Gene ID | 29994 |
Gene name | bromodomain adjacent to zinc finger domain 2B | |
Gene Alias | WALp4 | |
Cytomap | 2q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UIF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29994 | BAZ2B | A015-C-203 | Human | Colorectum | FAP | 9.34e-29 | 4.06e-02 | -0.1294 |
29994 | BAZ2B | A015-C-204 | Human | Colorectum | FAP | 2.60e-03 | 2.36e-02 | -0.0228 |
29994 | BAZ2B | A014-C-040 | Human | Colorectum | FAP | 2.63e-10 | 2.01e-01 | -0.1184 |
29994 | BAZ2B | A002-C-201 | Human | Colorectum | FAP | 1.33e-16 | 1.12e-01 | 0.0324 |
29994 | BAZ2B | A001-C-119 | Human | Colorectum | FAP | 1.87e-19 | 3.68e-01 | -0.1557 |
29994 | BAZ2B | A001-C-108 | Human | Colorectum | FAP | 4.42e-19 | 3.51e-01 | -0.0272 |
29994 | BAZ2B | A002-C-021 | Human | Colorectum | FAP | 2.99e-10 | 4.10e-01 | 0.1171 |
29994 | BAZ2B | A002-C-205 | Human | Colorectum | FAP | 5.90e-38 | 3.13e-01 | -0.1236 |
29994 | BAZ2B | A014-C-108 | Human | Colorectum | FAP | 1.32e-04 | 3.26e-01 | -0.124 |
29994 | BAZ2B | A001-C-104 | Human | Colorectum | FAP | 5.14e-13 | 3.57e-01 | 0.0184 |
29994 | BAZ2B | A015-C-005 | Human | Colorectum | FAP | 2.40e-04 | 2.26e-01 | -0.0336 |
29994 | BAZ2B | A015-C-006 | Human | Colorectum | FAP | 5.55e-20 | -2.53e-02 | -0.0994 |
29994 | BAZ2B | A015-C-106 | Human | Colorectum | FAP | 2.64e-09 | 8.14e-02 | -0.0511 |
29994 | BAZ2B | A002-C-114 | Human | Colorectum | FAP | 2.38e-29 | 2.09e-01 | -0.1561 |
29994 | BAZ2B | A015-C-104 | Human | Colorectum | FAP | 1.65e-37 | 1.55e-01 | -0.1899 |
29994 | BAZ2B | A015-C-202 | Human | Colorectum | FAP | 1.80e-04 | 2.99e-01 | -0.0849 |
29994 | BAZ2B | A001-C-014 | Human | Colorectum | FAP | 2.75e-16 | 1.43e-01 | 0.0135 |
29994 | BAZ2B | A002-C-016 | Human | Colorectum | FAP | 3.44e-28 | 2.18e-01 | 0.0521 |
29994 | BAZ2B | A015-C-002 | Human | Colorectum | FAP | 1.17e-12 | -2.20e-02 | -0.0763 |
29994 | BAZ2B | A001-C-203 | Human | Colorectum | FAP | 6.66e-17 | 2.62e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075689 | Cervix | CC | aging | 75/2311 | 339/18723 | 2.75e-07 | 1.13e-05 | 75 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00906473 | Cervix | CC | modulation of age-related behavioral decline | 5/2311 | 10/18723 | 4.20e-03 | 2.58e-02 | 5 |
GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00075681 | Colorectum | MSS | aging | 90/3467 | 339/18723 | 1.51e-04 | 2.19e-03 | 90 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:00075682 | Colorectum | FAP | aging | 69/2622 | 339/18723 | 7.66e-04 | 8.12e-03 | 69 |
GO:0090647 | Colorectum | FAP | modulation of age-related behavioral decline | 5/2622 | 10/18723 | 7.32e-03 | 4.38e-02 | 5 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:00906471 | Colorectum | CRC | modulation of age-related behavioral decline | 5/2078 | 10/18723 | 2.61e-03 | 2.40e-02 | 5 |
GO:000756810 | Endometrium | AEH | aging | 59/2100 | 339/18723 | 4.00e-04 | 4.28e-03 | 59 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:000756815 | Endometrium | EEC | aging | 66/2168 | 339/18723 | 1.46e-05 | 2.87e-04 | 66 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:000632516 | Esophagus | HGIN | chromatin organization | 92/2587 | 409/18723 | 1.05e-06 | 4.16e-05 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAZ2B | SNV | Missense_Mutation | c.6056N>G | p.Ser2019Cys | p.S2019C | Q9UIF8 | protein_coding | tolerated(0.06) | possibly_damaging(0.894) | TCGA-A8-A07F-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
BAZ2B | SNV | Missense_Mutation | rs756567864 | c.2411G>C | p.Ser804Thr | p.S804T | Q9UIF8 | protein_coding | deleterious(0) | benign(0.308) | TCGA-A8-A08X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD |
BAZ2B | SNV | Missense_Mutation | c.6001N>A | p.Glu2001Lys | p.E2001K | Q9UIF8 | protein_coding | tolerated(0.12) | possibly_damaging(0.63) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BAZ2B | SNV | Missense_Mutation | c.5827N>A | p.Glu1943Lys | p.E1943K | Q9UIF8 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BAZ2B | SNV | Missense_Mutation | rs771370768 | c.2192N>G | p.Ser731Cys | p.S731C | Q9UIF8 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BAZ2B | SNV | Missense_Mutation | c.1661N>G | p.Ser554Cys | p.S554C | Q9UIF8 | protein_coding | deleterious(0) | benign(0.299) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BAZ2B | SNV | Missense_Mutation | novel | c.4003N>A | p.Glu1335Lys | p.E1335K | Q9UIF8 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
BAZ2B | SNV | Missense_Mutation | rs755763510 | c.2740N>T | p.Arg914Trp | p.R914W | Q9UIF8 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BAZ2B | SNV | Missense_Mutation | novel | c.409N>T | p.Pro137Ser | p.P137S | Q9UIF8 | protein_coding | tolerated(0.12) | benign(0.014) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BAZ2B | SNV | Missense_Mutation | novel | c.1859N>G | p.Glu620Gly | p.E620G | Q9UIF8 | protein_coding | deleterious(0.03) | benign(0.356) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
29994 | BAZ2B | NA | ELLIPTECINE | ELLIPTECINE | ||
29994 | BAZ2B | NA | 4-HYDROXYESTRADIOL | CHEMBL1412489 | ||
29994 | BAZ2B | NA | SJ000018300 | CHEMBL590927 | ||
29994 | BAZ2B | NA | METHYLTHIONINIUM CHLORIDE | METHYLTHIONINIUM CHLORIDE | ||
29994 | BAZ2B | NA | GNF-PF-5381 | CHEMBL578109 | ||
29994 | BAZ2B | NA | BAS 01152706 | CHEMBL2002487 | ||
29994 | BAZ2B | NA | GNF-PF-4967 | CHEMBL585827 | ||
29994 | BAZ2B | NA | CEFACLOR | CEFACLOR | ||
29994 | BAZ2B | NA | LIPOIC ACID, ALPHA | LIPOIC ACID, ALPHA | ||
29994 | BAZ2B | NA | DNDI1417165 | CHEMBL1406948 |
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