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Gene: B3GNT3 |
Gene summary for B3GNT3 |
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Gene information | Species | Human | Gene symbol | B3GNT3 | Gene ID | 10331 |
Gene name | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | |
Gene Alias | B3GAL-T8 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q9Y2A9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10331 | B3GNT3 | P62T-E | Human | Esophagus | ESCC | 6.20e-11 | 3.72e-01 | 0.1302 |
10331 | B3GNT3 | P65T-E | Human | Esophagus | ESCC | 1.95e-03 | 2.72e-01 | 0.0978 |
10331 | B3GNT3 | P74T-E | Human | Esophagus | ESCC | 2.98e-02 | 1.92e-01 | 0.1479 |
10331 | B3GNT3 | P75T-E | Human | Esophagus | ESCC | 1.38e-56 | 1.34e+00 | 0.1125 |
10331 | B3GNT3 | P76T-E | Human | Esophagus | ESCC | 4.25e-06 | 1.58e-01 | 0.1207 |
10331 | B3GNT3 | P79T-E | Human | Esophagus | ESCC | 1.75e-13 | 2.59e-01 | 0.1154 |
10331 | B3GNT3 | P82T-E | Human | Esophagus | ESCC | 8.62e-20 | 1.28e+00 | 0.1072 |
10331 | B3GNT3 | P84T-E | Human | Esophagus | ESCC | 7.85e-04 | 7.32e-01 | 0.0933 |
10331 | B3GNT3 | P104T-E | Human | Esophagus | ESCC | 5.35e-05 | 5.10e-01 | 0.0931 |
10331 | B3GNT3 | P127T-E | Human | Esophagus | ESCC | 6.16e-03 | 1.40e-01 | 0.0826 |
10331 | B3GNT3 | P128T-E | Human | Esophagus | ESCC | 2.48e-35 | 1.12e+00 | 0.1241 |
10331 | B3GNT3 | HCC1_Meng | Human | Liver | HCC | 5.40e-18 | -3.62e-02 | 0.0246 |
10331 | B3GNT3 | HCC2_Meng | Human | Liver | HCC | 5.45e-46 | 2.86e-01 | 0.0107 |
10331 | B3GNT3 | cirrhotic1 | Human | Liver | Cirrhotic | 8.20e-08 | 1.38e-01 | 0.0202 |
10331 | B3GNT3 | cirrhotic2 | Human | Liver | Cirrhotic | 3.51e-03 | 4.62e-02 | 0.0201 |
10331 | B3GNT3 | S027 | Human | Liver | HCC | 1.12e-04 | 6.15e-01 | 0.2446 |
10331 | B3GNT3 | S028 | Human | Liver | HCC | 7.81e-11 | 5.46e-01 | 0.2503 |
10331 | B3GNT3 | S029 | Human | Liver | HCC | 4.50e-09 | 5.46e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
GO:0006024 | Esophagus | ESCC | glycosaminoglycan biosynthetic process | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:0006023 | Esophagus | ESCC | aminoglycan biosynthetic process | 47/8552 | 79/18723 | 9.29e-03 | 3.23e-02 | 47 |
GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
B3GNT3 | SNV | Missense_Mutation | c.766N>C | p.Glu256Gln | p.E256Q | Q9Y2A9 | protein_coding | tolerated(0.57) | benign(0.027) | TCGA-A8-A06T-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
B3GNT3 | SNV | Missense_Mutation | c.383N>A | p.Arg128His | p.R128H | Q9Y2A9 | protein_coding | deleterious(0.03) | probably_damaging(0.975) | TCGA-AR-A1AU-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
B3GNT3 | SNV | Missense_Mutation | c.542N>G | p.Ser181Cys | p.S181C | Q9Y2A9 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
B3GNT3 | SNV | Missense_Mutation | novel | c.1094N>C | p.Cys365Ser | p.C365S | Q9Y2A9 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-VS-A9UM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
B3GNT3 | SNV | Missense_Mutation | rs763164172 | c.787N>T | p.Arg263Trp | p.R263W | Q9Y2A9 | protein_coding | tolerated(0.19) | possibly_damaging(0.892) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
B3GNT3 | SNV | Missense_Mutation | c.919N>A | p.Glu307Lys | p.E307K | Q9Y2A9 | protein_coding | tolerated(0.12) | benign(0.122) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
B3GNT3 | SNV | Missense_Mutation | c.584N>T | p.Trp195Leu | p.W195L | Q9Y2A9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
B3GNT3 | SNV | Missense_Mutation | c.607G>A | p.Ala203Thr | p.A203T | Q9Y2A9 | protein_coding | deleterious(0.03) | benign(0.365) | TCGA-AP-A0LJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
B3GNT3 | SNV | Missense_Mutation | novel | c.676N>A | p.Asp226Asn | p.D226N | Q9Y2A9 | protein_coding | tolerated(0.53) | benign(0.026) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
B3GNT3 | SNV | Missense_Mutation | rs199719531 | c.1034N>A | p.Arg345His | p.R345H | Q9Y2A9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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