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Gene: ATP6AP2 |
Gene summary for ATP6AP2 |
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Gene information | Species | Human | Gene symbol | ATP6AP2 | Gene ID | 10159 |
Gene name | ATPase H+ transporting accessory protein 2 | |
Gene Alias | APT6M8-9 | |
Cytomap | Xp11.4 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O75787 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10159 | ATP6AP2 | LZE7T | Human | Esophagus | ESCC | 1.06e-03 | 5.90e-01 | 0.0667 |
10159 | ATP6AP2 | LZE8T | Human | Esophagus | ESCC | 2.76e-12 | 7.47e-01 | 0.067 |
10159 | ATP6AP2 | LZE20T | Human | Esophagus | ESCC | 3.81e-06 | 6.62e-01 | 0.0662 |
10159 | ATP6AP2 | LZE22T | Human | Esophagus | ESCC | 4.33e-02 | 5.18e-01 | 0.068 |
10159 | ATP6AP2 | LZE24T | Human | Esophagus | ESCC | 1.30e-19 | 8.31e-01 | 0.0596 |
10159 | ATP6AP2 | LZE6T | Human | Esophagus | ESCC | 5.64e-04 | 3.95e-01 | 0.0845 |
10159 | ATP6AP2 | P1T-E | Human | Esophagus | ESCC | 1.27e-04 | 7.07e-01 | 0.0875 |
10159 | ATP6AP2 | P2T-E | Human | Esophagus | ESCC | 8.73e-71 | 1.44e+00 | 0.1177 |
10159 | ATP6AP2 | P4T-E | Human | Esophagus | ESCC | 5.57e-51 | 1.43e+00 | 0.1323 |
10159 | ATP6AP2 | P5T-E | Human | Esophagus | ESCC | 3.01e-21 | 7.06e-01 | 0.1327 |
10159 | ATP6AP2 | P8T-E | Human | Esophagus | ESCC | 1.61e-77 | 1.86e+00 | 0.0889 |
10159 | ATP6AP2 | P9T-E | Human | Esophagus | ESCC | 9.31e-11 | 5.31e-01 | 0.1131 |
10159 | ATP6AP2 | P10T-E | Human | Esophagus | ESCC | 4.68e-56 | 1.18e+00 | 0.116 |
10159 | ATP6AP2 | P11T-E | Human | Esophagus | ESCC | 1.11e-33 | 1.42e+00 | 0.1426 |
10159 | ATP6AP2 | P12T-E | Human | Esophagus | ESCC | 2.20e-49 | 9.57e-01 | 0.1122 |
10159 | ATP6AP2 | P15T-E | Human | Esophagus | ESCC | 2.47e-43 | 1.21e+00 | 0.1149 |
10159 | ATP6AP2 | P16T-E | Human | Esophagus | ESCC | 3.73e-83 | 1.94e+00 | 0.1153 |
10159 | ATP6AP2 | P17T-E | Human | Esophagus | ESCC | 2.26e-12 | 8.89e-01 | 0.1278 |
10159 | ATP6AP2 | P19T-E | Human | Esophagus | ESCC | 1.06e-08 | 1.20e+00 | 0.1662 |
10159 | ATP6AP2 | P20T-E | Human | Esophagus | ESCC | 6.02e-39 | 1.10e+00 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301118 | Endometrium | AEH | regulation of Wnt signaling pathway | 71/2100 | 328/18723 | 3.31e-08 | 1.87e-06 | 71 |
GO:00160558 | Endometrium | AEH | Wnt signaling pathway | 85/2100 | 444/18723 | 4.99e-07 | 1.97e-05 | 85 |
GO:01987388 | Endometrium | AEH | cell-cell signaling by wnt | 85/2100 | 446/18723 | 6.07e-07 | 2.29e-05 | 85 |
GO:00608288 | Endometrium | AEH | regulation of canonical Wnt signaling pathway | 54/2100 | 253/18723 | 2.22e-06 | 6.56e-05 | 54 |
GO:00301777 | Endometrium | AEH | positive regulation of Wnt signaling pathway | 34/2100 | 140/18723 | 9.62e-06 | 2.23e-04 | 34 |
GO:00600708 | Endometrium | AEH | canonical Wnt signaling pathway | 58/2100 | 303/18723 | 3.12e-05 | 5.66e-04 | 58 |
GO:00902637 | Endometrium | AEH | positive regulation of canonical Wnt signaling pathway | 26/2100 | 106/18723 | 8.63e-05 | 1.27e-03 | 26 |
GO:00018198 | Endometrium | AEH | positive regulation of cytokine production | 71/2100 | 467/18723 | 4.76e-03 | 3.02e-02 | 71 |
GO:003011113 | Endometrium | EEC | regulation of Wnt signaling pathway | 74/2168 | 328/18723 | 1.03e-08 | 6.47e-07 | 74 |
GO:001605513 | Endometrium | EEC | Wnt signaling pathway | 90/2168 | 444/18723 | 6.65e-08 | 3.50e-06 | 90 |
GO:019873813 | Endometrium | EEC | cell-cell signaling by wnt | 90/2168 | 446/18723 | 8.25e-08 | 4.23e-06 | 90 |
GO:006082813 | Endometrium | EEC | regulation of canonical Wnt signaling pathway | 56/2168 | 253/18723 | 1.18e-06 | 3.90e-05 | 56 |
GO:006007013 | Endometrium | EEC | canonical Wnt signaling pathway | 61/2168 | 303/18723 | 1.05e-05 | 2.25e-04 | 61 |
GO:003017713 | Endometrium | EEC | positive regulation of Wnt signaling pathway | 34/2168 | 140/18723 | 1.89e-05 | 3.50e-04 | 34 |
GO:009026313 | Endometrium | EEC | positive regulation of canonical Wnt signaling pathway | 26/2168 | 106/18723 | 1.46e-04 | 1.87e-03 | 26 |
GO:000181913 | Endometrium | EEC | positive regulation of cytokine production | 73/2168 | 467/18723 | 4.64e-03 | 2.97e-02 | 73 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP6AP2 | SNV | Missense_Mutation | rs745734335 | c.454N>T | p.Arg152Cys | p.R152C | O75787 | protein_coding | deleterious(0) | possibly_damaging(0.644) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP6AP2 | SNV | Missense_Mutation | c.515C>A | p.Ser172Tyr | p.S172Y | O75787 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP6AP2 | SNV | Missense_Mutation | c.1017T>G | p.Ile339Met | p.I339M | O75787 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ATP6AP2 | SNV | Missense_Mutation | rs375148460 | c.262N>G | p.Leu88Val | p.L88V | O75787 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATP6AP2 | SNV | Missense_Mutation | c.133N>A | p.Val45Met | p.V45M | O75787 | protein_coding | deleterious(0.02) | benign(0.054) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP6AP2 | SNV | Missense_Mutation | c.152G>C | p.Gly51Ala | p.G51A | O75787 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP6AP2 | SNV | Missense_Mutation | novel | c.406A>G | p.Met136Val | p.M136V | O75787 | protein_coding | tolerated(0.36) | benign(0.046) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ATP6AP2 | SNV | Missense_Mutation | c.739N>C | p.Phe247Leu | p.F247L | O75787 | protein_coding | deleterious(0.03) | benign(0.028) | TCGA-NH-A50T-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP6AP2 | SNV | Missense_Mutation | c.1043N>A | p.Arg348Gln | p.R348Q | O75787 | protein_coding | tolerated(0.05) | possibly_damaging(0.756) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ATP6AP2 | SNV | Missense_Mutation | novel | c.662N>T | p.Glu221Val | p.E221V | O75787 | protein_coding | tolerated(0.05) | benign(0.034) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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