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Gene: ATF7IP2 |
Gene summary for ATF7IP2 |
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Gene information | Species | Human | Gene symbol | ATF7IP2 | Gene ID | 80063 |
Gene name | activating transcription factor 7 interacting protein 2 | |
Gene Alias | MCAF2 | |
Cytomap | 16p13.2-p13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5U623 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80063 | ATF7IP2 | A002-C-016 | Human | Colorectum | FAP | 5.66e-09 | 2.86e-01 | 0.0521 |
80063 | ATF7IP2 | A002-C-116 | Human | Colorectum | FAP | 1.32e-12 | -2.53e-02 | -0.0452 |
80063 | ATF7IP2 | A008-E-015 | Human | Colorectum | FAP | 1.85e-03 | 3.64e-01 | 0.0177 |
80063 | ATF7IP2 | A014-C-008 | Human | Colorectum | FAP | 2.71e-02 | 4.58e-02 | -0.191 |
80063 | ATF7IP2 | A018-E-020 | Human | Colorectum | FAP | 4.70e-03 | -7.00e-02 | -0.2034 |
80063 | ATF7IP2 | F034 | Human | Colorectum | FAP | 2.10e-09 | 3.79e-01 | -0.0665 |
80063 | ATF7IP2 | CRC-1-8810 | Human | Colorectum | CRC | 7.60e-04 | 4.20e-01 | 0.6257 |
80063 | ATF7IP2 | CRC-3-11773 | Human | Colorectum | CRC | 4.59e-17 | 6.04e-01 | 0.2564 |
80063 | ATF7IP2 | LZE4T | Human | Esophagus | ESCC | 1.35e-12 | 4.10e-01 | 0.0811 |
80063 | ATF7IP2 | LZE7T | Human | Esophagus | ESCC | 2.03e-05 | 2.88e-01 | 0.0667 |
80063 | ATF7IP2 | LZE22T | Human | Esophagus | ESCC | 3.35e-03 | 2.61e-01 | 0.068 |
80063 | ATF7IP2 | LZE24T | Human | Esophagus | ESCC | 2.67e-09 | 1.99e-01 | 0.0596 |
80063 | ATF7IP2 | LZE6T | Human | Esophagus | ESCC | 3.72e-07 | 3.91e-01 | 0.0845 |
80063 | ATF7IP2 | P1T-E | Human | Esophagus | ESCC | 1.49e-08 | 3.52e-01 | 0.0875 |
80063 | ATF7IP2 | P2T-E | Human | Esophagus | ESCC | 3.92e-10 | 1.67e-01 | 0.1177 |
80063 | ATF7IP2 | P4T-E | Human | Esophagus | ESCC | 1.33e-10 | 2.99e-01 | 0.1323 |
80063 | ATF7IP2 | P5T-E | Human | Esophagus | ESCC | 1.41e-24 | 5.65e-01 | 0.1327 |
80063 | ATF7IP2 | P8T-E | Human | Esophagus | ESCC | 4.22e-14 | 2.72e-01 | 0.0889 |
80063 | ATF7IP2 | P9T-E | Human | Esophagus | ESCC | 2.09e-07 | 7.49e-02 | 0.1131 |
80063 | ATF7IP2 | P16T-E | Human | Esophagus | ESCC | 5.61e-06 | 1.33e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATF7IP2 | SNV | Missense_Mutation | c.1518G>C | p.Leu506Phe | p.L506F | Q5U623 | protein_coding | deleterious(0.02) | benign(0.084) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ATF7IP2 | SNV | Missense_Mutation | novel | c.668N>G | p.Asp223Gly | p.D223G | Q5U623 | protein_coding | deleterious(0.01) | benign(0.14) | TCGA-EW-A3U0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ATF7IP2 | insertion | In_Frame_Ins | novel | c.1996_1997insCACGCACAGCTAATTTTTGTATTTTTAGTA | p.Gly666delinsAlaArgThrAlaAsnPheCysIlePheSerArg | p.G666delinsARTANFCIFSR | Q5U623 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ATF7IP2 | insertion | Frame_Shift_Ins | novel | c.692_693insTACTTTACTTTTCTCTGATATTG | p.Lys231AsnfsTer14 | p.K231Nfs*14 | Q5U623 | protein_coding | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
ATF7IP2 | SNV | Missense_Mutation | novel | c.1546A>G | p.Thr516Ala | p.T516A | Q5U623 | protein_coding | tolerated(0.09) | benign(0.058) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ATF7IP2 | SNV | Missense_Mutation | c.1717N>G | p.Thr573Ala | p.T573A | Q5U623 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATF7IP2 | SNV | Missense_Mutation | novel | c.635A>G | p.Lys212Arg | p.K212R | Q5U623 | protein_coding | deleterious(0.01) | possibly_damaging(0.725) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ATF7IP2 | SNV | Missense_Mutation | rs746602868 | c.1123N>G | p.Ile375Val | p.I375V | Q5U623 | protein_coding | tolerated(0.19) | benign(0.022) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ATF7IP2 | SNV | Missense_Mutation | c.485N>A | p.Cys162Tyr | p.C162Y | Q5U623 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ATF7IP2 | SNV | Missense_Mutation | novel | c.1166A>G | p.Asn389Ser | p.N389S | Q5U623 | protein_coding | tolerated(0.18) | benign(0.048) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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