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Gene: ARHGAP18 |
Gene summary for ARHGAP18 |
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Gene information | Species | Human | Gene symbol | ARHGAP18 | Gene ID | 93663 |
Gene name | Rho GTPase activating protein 18 | |
Gene Alias | MacGAP | |
Cytomap | 6q22.33 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8N392 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93663 | ARHGAP18 | P16T-E | Human | Esophagus | ESCC | 8.54e-13 | 2.64e-01 | 0.1153 |
93663 | ARHGAP18 | P17T-E | Human | Esophagus | ESCC | 2.96e-02 | 3.11e-01 | 0.1278 |
93663 | ARHGAP18 | P21T-E | Human | Esophagus | ESCC | 5.13e-18 | 2.20e-01 | 0.1617 |
93663 | ARHGAP18 | P23T-E | Human | Esophagus | ESCC | 1.55e-15 | 3.28e-01 | 0.108 |
93663 | ARHGAP18 | P24T-E | Human | Esophagus | ESCC | 4.15e-13 | 1.79e-01 | 0.1287 |
93663 | ARHGAP18 | P26T-E | Human | Esophagus | ESCC | 3.83e-06 | 8.34e-02 | 0.1276 |
93663 | ARHGAP18 | P30T-E | Human | Esophagus | ESCC | 1.72e-03 | 2.21e-01 | 0.137 |
93663 | ARHGAP18 | P31T-E | Human | Esophagus | ESCC | 3.19e-17 | 4.53e-01 | 0.1251 |
93663 | ARHGAP18 | P32T-E | Human | Esophagus | ESCC | 3.48e-03 | 3.97e-02 | 0.1666 |
93663 | ARHGAP18 | P36T-E | Human | Esophagus | ESCC | 2.97e-09 | 2.99e-01 | 0.1187 |
93663 | ARHGAP18 | P37T-E | Human | Esophagus | ESCC | 1.28e-07 | 1.17e-01 | 0.1371 |
93663 | ARHGAP18 | P39T-E | Human | Esophagus | ESCC | 5.39e-09 | 2.99e-01 | 0.0894 |
93663 | ARHGAP18 | P42T-E | Human | Esophagus | ESCC | 1.04e-03 | 9.60e-02 | 0.1175 |
93663 | ARHGAP18 | P44T-E | Human | Esophagus | ESCC | 4.75e-04 | 1.60e-01 | 0.1096 |
93663 | ARHGAP18 | P47T-E | Human | Esophagus | ESCC | 4.89e-03 | 1.67e-02 | 0.1067 |
93663 | ARHGAP18 | P48T-E | Human | Esophagus | ESCC | 3.44e-02 | 4.30e-02 | 0.0959 |
93663 | ARHGAP18 | P52T-E | Human | Esophagus | ESCC | 8.35e-09 | 6.72e-02 | 0.1555 |
93663 | ARHGAP18 | P57T-E | Human | Esophagus | ESCC | 1.67e-18 | 3.73e-01 | 0.0926 |
93663 | ARHGAP18 | P61T-E | Human | Esophagus | ESCC | 1.57e-12 | 2.80e-01 | 0.099 |
93663 | ARHGAP18 | P62T-E | Human | Esophagus | ESCC | 9.15e-21 | 3.87e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00308339 | Cervix | CC | regulation of actin filament polymerization | 40/2311 | 172/18723 | 4.90e-05 | 7.40e-04 | 40 |
GO:00080649 | Cervix | CC | regulation of actin polymerization or depolymerization | 42/2311 | 188/18723 | 8.60e-05 | 1.15e-03 | 42 |
GO:00308328 | Cervix | CC | regulation of actin filament length | 42/2311 | 189/18723 | 9.76e-05 | 1.27e-03 | 42 |
GO:000701515 | Cervix | HSIL_HPV | actin filament organization | 43/737 | 442/18723 | 4.77e-08 | 3.59e-06 | 43 |
GO:003295615 | Cervix | HSIL_HPV | regulation of actin cytoskeleton organization | 33/737 | 358/18723 | 5.61e-06 | 2.09e-04 | 33 |
GO:003297015 | Cervix | HSIL_HPV | regulation of actin filament-based process | 35/737 | 397/18723 | 7.87e-06 | 2.81e-04 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP18 | SNV | Missense_Mutation | novel | c.1889G>C | p.Gly630Ala | p.G630A | Q8N392 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ARHGAP18 | SNV | Missense_Mutation | rs775517266 | c.1027N>T | p.Pro343Ser | p.P343S | Q8N392 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-A2-A0EW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ARHGAP18 | SNV | Missense_Mutation | c.1342N>C | p.Asp448His | p.D448H | Q8N392 | protein_coding | deleterious(0) | benign(0.158) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
ARHGAP18 | SNV | Missense_Mutation | c.556C>G | p.Pro186Ala | p.P186A | Q8N392 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARHGAP18 | SNV | Missense_Mutation | rs370593148 | c.769G>A | p.Asp257Asn | p.D257N | Q8N392 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP18 | SNV | Missense_Mutation | c.29N>C | p.Val10Ala | p.V10A | Q8N392 | protein_coding | deleterious(0) | benign(0.138) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
ARHGAP18 | SNV | Missense_Mutation | novel | c.997N>C | p.Asp333His | p.D333H | Q8N392 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ARHGAP18 | SNV | Missense_Mutation | c.375G>T | p.Glu125Asp | p.E125D | Q8N392 | protein_coding | tolerated(0.63) | benign(0.003) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
ARHGAP18 | SNV | Missense_Mutation | c.1562N>G | p.Leu521Arg | p.L521R | Q8N392 | protein_coding | deleterious(0) | benign(0.196) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARHGAP18 | SNV | Missense_Mutation | c.1208N>C | p.Leu403Pro | p.L403P | Q8N392 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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