![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: AP1G2 |
Gene summary for AP1G2 |
![]() |
Gene information | Species | Human | Gene symbol | AP1G2 | Gene ID | 8906 |
Gene name | adaptor related protein complex 1 subunit gamma 2 | |
Gene Alias | G2AD | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q86U03 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8906 | AP1G2 | P15T-E | Human | Esophagus | ESCC | 3.12e-35 | 7.55e-01 | 0.1149 |
8906 | AP1G2 | P16T-E | Human | Esophagus | ESCC | 6.33e-13 | 1.41e-01 | 0.1153 |
8906 | AP1G2 | P17T-E | Human | Esophagus | ESCC | 4.19e-11 | 4.60e-01 | 0.1278 |
8906 | AP1G2 | P19T-E | Human | Esophagus | ESCC | 3.52e-03 | 1.57e-01 | 0.1662 |
8906 | AP1G2 | P20T-E | Human | Esophagus | ESCC | 5.90e-13 | 1.25e-01 | 0.1124 |
8906 | AP1G2 | P21T-E | Human | Esophagus | ESCC | 3.46e-16 | 3.45e-01 | 0.1617 |
8906 | AP1G2 | P22T-E | Human | Esophagus | ESCC | 2.30e-18 | 2.99e-01 | 0.1236 |
8906 | AP1G2 | P23T-E | Human | Esophagus | ESCC | 1.13e-13 | 4.24e-01 | 0.108 |
8906 | AP1G2 | P24T-E | Human | Esophagus | ESCC | 1.37e-07 | 2.16e-01 | 0.1287 |
8906 | AP1G2 | P26T-E | Human | Esophagus | ESCC | 1.58e-19 | 3.49e-01 | 0.1276 |
8906 | AP1G2 | P27T-E | Human | Esophagus | ESCC | 1.68e-21 | 5.49e-01 | 0.1055 |
8906 | AP1G2 | P28T-E | Human | Esophagus | ESCC | 1.57e-32 | 5.89e-01 | 0.1149 |
8906 | AP1G2 | P30T-E | Human | Esophagus | ESCC | 4.96e-23 | 6.76e-01 | 0.137 |
8906 | AP1G2 | P31T-E | Human | Esophagus | ESCC | 1.51e-25 | 4.08e-01 | 0.1251 |
8906 | AP1G2 | P32T-E | Human | Esophagus | ESCC | 1.81e-08 | 7.09e-02 | 0.1666 |
8906 | AP1G2 | P36T-E | Human | Esophagus | ESCC | 6.32e-11 | 4.56e-01 | 0.1187 |
8906 | AP1G2 | P37T-E | Human | Esophagus | ESCC | 1.33e-19 | 2.83e-01 | 0.1371 |
8906 | AP1G2 | P38T-E | Human | Esophagus | ESCC | 1.21e-06 | 3.96e-01 | 0.127 |
8906 | AP1G2 | P39T-E | Human | Esophagus | ESCC | 9.26e-21 | 3.55e-01 | 0.0894 |
8906 | AP1G2 | P40T-E | Human | Esophagus | ESCC | 3.54e-17 | 2.11e-01 | 0.109 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819317 | Esophagus | HGIN | Golgi vesicle transport | 83/2587 | 296/18723 | 8.59e-11 | 8.89e-09 | 83 |
GO:000689210 | Esophagus | HGIN | post-Golgi vesicle-mediated transport | 26/2587 | 104/18723 | 1.63e-03 | 1.81e-02 | 26 |
GO:000703416 | Esophagus | HGIN | vacuolar transport | 35/2587 | 157/18723 | 2.52e-03 | 2.51e-02 | 35 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:00068963 | Esophagus | ESCC | Golgi to vacuole transport | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:000703410 | Oral cavity | OSCC | vacuolar transport | 103/7305 | 157/18723 | 1.25e-11 | 4.44e-10 | 103 |
GO:00068929 | Oral cavity | OSCC | post-Golgi vesicle-mediated transport | 71/7305 | 104/18723 | 1.37e-09 | 3.33e-08 | 71 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:00068962 | Oral cavity | OSCC | Golgi to vacuole transport | 14/7305 | 20/18723 | 4.95e-03 | 1.94e-02 | 14 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:000703415 | Oral cavity | LP | vacuolar transport | 74/4623 | 157/18723 | 7.85e-10 | 3.70e-08 | 74 |
GO:000689214 | Oral cavity | LP | post-Golgi vesicle-mediated transport | 44/4623 | 104/18723 | 5.90e-05 | 8.05e-04 | 44 |
GO:000689817 | Oral cavity | LP | receptor-mediated endocytosis | 87/4623 | 244/18723 | 7.83e-05 | 1.02e-03 | 87 |
GO:00068961 | Oral cavity | LP | Golgi to vacuole transport | 12/4623 | 20/18723 | 8.24e-04 | 7.23e-03 | 12 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000703419 | Skin | cSCC | vacuolar transport | 74/4864 | 157/18723 | 8.60e-09 | 2.72e-07 | 74 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517029 | Esophagus | HGIN | Human immunodeficiency virus 1 infection | 51/1383 | 212/8465 | 2.16e-03 | 1.90e-02 | 1.51e-02 | 51 |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa05170112 | Esophagus | HGIN | Human immunodeficiency virus 1 infection | 51/1383 | 212/8465 | 2.16e-03 | 1.90e-02 | 1.51e-02 | 51 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0517027 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa05170111 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0517037 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP1G2 | SNV | Missense_Mutation | c.361G>A | p.Gly121Ser | p.G121S | O75843 | protein_coding | tolerated(0.19) | possibly_damaging(0.889) | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
AP1G2 | SNV | Missense_Mutation | novel | c.1976N>A | p.Cys659Tyr | p.C659Y | O75843 | protein_coding | tolerated(0.13) | benign(0.191) | TCGA-A2-A0ES-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
AP1G2 | SNV | Missense_Mutation | novel | c.381N>C | p.Leu127Phe | p.L127F | O75843 | protein_coding | tolerated(0.12) | probably_damaging(0.962) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
AP1G2 | SNV | Missense_Mutation | rs138395869 | c.610N>A | p.Glu204Lys | p.E204K | O75843 | protein_coding | deleterious(0.05) | benign(0.062) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AP1G2 | SNV | Missense_Mutation | c.495G>A | p.Met165Ile | p.M165I | O75843 | protein_coding | tolerated(1) | benign(0.007) | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
AP1G2 | SNV | Missense_Mutation | c.2348N>T | p.Ser783Leu | p.S783L | O75843 | protein_coding | tolerated(0.35) | benign(0.058) | TCGA-E9-A1R6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
AP1G2 | SNV | Missense_Mutation | c.1163N>A | p.Ala388Asp | p.A388D | O75843 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
AP1G2 | insertion | Frame_Shift_Ins | rs749982998 | c.1345_1346insG | p.Ala449GlyfsTer49 | p.A449Gfs*49 | O75843 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
AP1G2 | insertion | In_Frame_Ins | novel | c.994_995insGCCCAGCCCTCCCTACCC | p.Ser332delinsCysProAlaLeuProThrPro | p.S332delinsCPALPTP | O75843 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
AP1G2 | deletion | Frame_Shift_Del | novel | c.1241delN | p.Pro414GlnfsTer7 | p.P414Qfs*7 | O75843 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |