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Gene: ANXA2R |
Gene summary for ANXA2R |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ANXA2R | Gene ID | 389289 |
| Gene name | annexin A2 receptor | |
| Gene Alias | AX2R | |
| Cytomap | 5p12 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q3ZCQ2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 389289 | ANXA2R | P37T-E | Human | Esophagus | ESCC | 1.53e-03 | 9.86e-02 | 0.1371 |
| 389289 | ANXA2R | P47T-E | Human | Esophagus | ESCC | 1.78e-03 | 8.40e-02 | 0.1067 |
| 389289 | ANXA2R | P48T-E | Human | Esophagus | ESCC | 1.78e-03 | 8.23e-02 | 0.0959 |
| 389289 | ANXA2R | P54T-E | Human | Esophagus | ESCC | 9.07e-08 | 1.72e-01 | 0.0975 |
| 389289 | ANXA2R | P57T-E | Human | Esophagus | ESCC | 3.29e-03 | 7.47e-02 | 0.0926 |
| 389289 | ANXA2R | P62T-E | Human | Esophagus | ESCC | 7.77e-17 | 2.75e-01 | 0.1302 |
| 389289 | ANXA2R | P65T-E | Human | Esophagus | ESCC | 9.07e-04 | 9.54e-02 | 0.0978 |
| 389289 | ANXA2R | P74T-E | Human | Esophagus | ESCC | 1.26e-23 | 1.00e+00 | 0.1479 |
| 389289 | ANXA2R | P75T-E | Human | Esophagus | ESCC | 2.00e-17 | 3.81e-01 | 0.1125 |
| 389289 | ANXA2R | P76T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.33e-02 | 0.1207 |
| 389289 | ANXA2R | P80T-E | Human | Esophagus | ESCC | 1.97e-04 | 1.39e-01 | 0.155 |
| 389289 | ANXA2R | P82T-E | Human | Esophagus | ESCC | 2.98e-07 | 3.10e-01 | 0.1072 |
| 389289 | ANXA2R | P107T-E | Human | Esophagus | ESCC | 8.98e-03 | 7.80e-02 | 0.171 |
| 389289 | ANXA2R | P127T-E | Human | Esophagus | ESCC | 1.56e-02 | 5.95e-02 | 0.0826 |
| 389289 | ANXA2R | P128T-E | Human | Esophagus | ESCC | 5.60e-09 | 2.76e-01 | 0.1241 |
| 389289 | ANXA2R | P130T-E | Human | Esophagus | ESCC | 4.33e-07 | 2.10e-01 | 0.1676 |
| 389289 | ANXA2R | C30 | Human | Oral cavity | OSCC | 5.50e-12 | 6.38e-01 | 0.3055 |
| 389289 | ANXA2R | C43 | Human | Oral cavity | OSCC | 3.63e-08 | 2.35e-01 | 0.1704 |
| 389289 | ANXA2R | C08 | Human | Oral cavity | OSCC | 5.44e-22 | 4.45e-01 | 0.1919 |
| 389289 | ANXA2R | LP15 | Human | Oral cavity | LP | 8.17e-05 | 7.92e-01 | 0.2174 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ANXA2R | SNV | Missense_Mutation | c.197G>A | p.Gly66Glu | p.G66E | Q3ZCQ2 | protein_coding | tolerated(0.26) | benign(0.075) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ANXA2R | SNV | Missense_Mutation | c.121T>C | p.Tyr41His | p.Y41H | Q3ZCQ2 | protein_coding | deleterious(0) | possibly_damaging(0.662) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
| ANXA2R | SNV | Missense_Mutation | c.371N>T | p.Ser124Ile | p.S124I | Q3ZCQ2 | protein_coding | tolerated(0.32) | benign(0.01) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ANXA2R | SNV | Missense_Mutation | novel | c.293N>C | p.Lys98Thr | p.K98T | Q3ZCQ2 | protein_coding | tolerated(0.34) | possibly_damaging(0.451) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| ANXA2R | SNV | Missense_Mutation | novel | c.275N>T | p.Ser92Ile | p.S92I | Q3ZCQ2 | protein_coding | tolerated(0.42) | benign(0.01) | TCGA-AX-A1CF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxifen | PD |
| ANXA2R | SNV | Missense_Mutation | novel | c.103C>T | p.Pro35Ser | p.P35S | Q3ZCQ2 | protein_coding | deleterious(0.04) | possibly_damaging(0.737) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ANXA2R | SNV | Missense_Mutation | novel | c.40N>A | p.Asp14Asn | p.D14N | Q3ZCQ2 | protein_coding | tolerated(0.27) | benign(0.32) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| ANXA2R | SNV | Missense_Mutation | novel | c.104N>G | p.Pro35Arg | p.P35R | Q3ZCQ2 | protein_coding | tolerated(0.09) | possibly_damaging(0.597) | TCGA-DD-AACP-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ANXA2R | SNV | Missense_Mutation | novel | c.143C>T | p.Ser48Leu | p.S48L | Q3ZCQ2 | protein_coding | tolerated(0.08) | benign(0.204) | TCGA-MP-A4TI-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| ANXA2R | SNV | Missense_Mutation | rs754645658 | c.514N>T | p.Val172Phe | p.V172F | Q3ZCQ2 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.859) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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